PMID- 35058706
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 1178-7031 (Print)
IS  - 1178-7031 (Electronic)
IS  - 1178-7031 (Linking)
VI  - 15
DP  - 2022
TI  - The Relationship Between Mild Cognitive Impairment and 
      Anti-Inflammatory/Pro-Inflammatory Nutrients in the Elderly in Northern China: A 
      Bayesian Kernel Machine Regression Approach.
PG  - 325-339
LID - 10.2147/JIR.S342672 [doi]
AB  - OBJECTIVE: This study aims to explore the role of nutrients with pro-inflammatory 
      or anti-inflammatory potential in the risk of mild cognitive impairment in the 
      elderly. METHODS: We evaluated the intake of 22 nutrients in the baseline survey 
      data of 612 elderly people in northern China. Meanwhile, the least absolute 
      contraction and selection operator (LASSO) regression analysis was used to screen 
      the nutrients with strong correlation with MCI. Bayesian kernel machine 
      regression (BKMR) was devoted to explore the possible associations between 
      various nutrients with different inflammatory potentials and the risk of mild 
      cognitive impairment. RESULTS: A total of 253 people (41.3%) were diagnosed with 
      mild cognition. Ten nutrients are significantly related to the risk of MCI and 
      were screened by a lasso regression model, including 5 pro-inflammatory nutrients 
      (inflammation effect score >0) and 5 anti-inflammatory nutrients (inflammation 
      effect score <0). We incorporated the inflammatory effect scores of 10 nutrients 
      into the BKMR model, and the results showed that the inflammatory effect of 10 
      nutrients continued to rise with the increase in inflammation scores, proposing 
      that the overall effect is pro-inflammatory. The BKMR analysis results of the 
      pro-inflammatory group and the anti-inflammatory group showed that multiple 
      nutrients in the two groups had a significant combined effect on mild cognitive 
      impairment. We found that by comparing the overall effect of inflammation and the 
      effect of a single group, we found that the inflammation effect of the 
      pro-inflammatory diet and the anti-inflammatory diet had a certain offsetting 
      effect (P < 0.005). CONCLUSION: In the elderly population in northern China, 
      pro-inflammatory diets are associated with an increased risk of mild cognitive 
      impairment. However, these results need to be further evaluated and verified in 
      more prospective studies.
CI  - (c) 2022 Li et al.
FAU - Li, Ruiqiang
AU  - Li R
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical 
      University, Hebei Province Key Laboratory of Environment and Human Health, 
      Shijiazhuang, People's Republic of China.
FAU - Zhan, Wenqiang
AU  - Zhan W
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, People's Republic of China.
FAU - Huang, Xin
AU  - Huang X
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical 
      University, Hebei Province Key Laboratory of Environment and Human Health, 
      Shijiazhuang, People's Republic of China.
FAU - Zhang, Limin
AU  - Zhang L
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical 
      University, Hebei Province Key Laboratory of Environment and Human Health, 
      Shijiazhuang, People's Republic of China.
FAU - Zhang, Zechen
AU  - Zhang Z
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical 
      University, Hebei Province Key Laboratory of Environment and Human Health, 
      Shijiazhuang, People's Republic of China.
FAU - Zhou, Meiqi
AU  - Zhou M
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical 
      University, Hebei Province Key Laboratory of Environment and Human Health, 
      Shijiazhuang, People's Republic of China.
FAU - Wang, Zhihong
AU  - Wang Z
AD  - National Institute for Nutrition and Health, Chinese Center for Disease Control 
      and Prevention, Beijing, People's Republic of China.
FAU - Ma, Yuxia
AU  - Ma Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical 
      University, Hebei Province Key Laboratory of Environment and Human Health, 
      Shijiazhuang, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20220114
PL  - New Zealand
TA  - J Inflamm Res
JT  - Journal of inflammation research
JID - 101512684
PMC - PMC8765544
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - anti-inflammatory
OT  - elderly
OT  - mild cognitive impairment
OT  - pro-inflammatory
COIS- The authors report no conflicts of interest in this work.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/22 06:01
PMCR- 2022/01/14
CRDT- 2022/01/21 06:17
PHST- 2021/10/23 00:00 [received]
PHST- 2021/12/31 00:00 [accepted]
PHST- 2022/01/21 06:17 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/22 06:01 [medline]
PHST- 2022/01/14 00:00 [pmc-release]
AID - 342672 [pii]
AID - 10.2147/JIR.S342672 [doi]
PST - epublish
SO  - J Inflamm Res. 2022 Jan 14;15:325-339. doi: 10.2147/JIR.S342672. eCollection 
      2022.