PMID- 35059177
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 2041-6520 (Print)
IS  - 2041-6539 (Electronic)
IS  - 2041-6520 (Linking)
VI  - 13
IP  - 1
DP  - 2021 Dec 22
TI  - Spatiotemporal dynamics of self-assembled structures in enzymatically induced 
      agonistic and antagonistic conditions.
PG  - 274-282
LID - 10.1039/d1sc05353a [doi]
AB  - Predicting and designing systems with dynamic self-assembly properties in a 
      spatiotemporal fashion is an important research area across disciplines ranging 
      from understanding the fundamental non-equilibrium features of life to the 
      fabrication of next-generation materials with life-like properties. Herein, we 
      demonstrate a spatiotemporal dynamics pattern in the self-assembly behavior of a 
      surfactant from an unorganized assembly, induced by adenosine triphosphate (ATP) 
      and enzymes responsible for the degradation or conversion of ATP. We report the 
      different behavior of two enzymes, alkaline phosphatase (ALP) and hexokinase 
      (HK), towards adenosine triphosphate (ATP)-driven surfactant assembly, which also 
      results in contrasting spatiotemporal dynamic assembly behavior. Here, ALP acts 
      antagonistically, resulting in transient self-assemblies, whereas HK shows 
      agonistic action with the ability to sustain the assemblies. This dynamic 
      assembly behavior was then used to program the time-dependent emergence of a 
      self-assembled structure in a two-dimensional space by maintaining concentration 
      gradients of the enzymes and surfactant at different locations, demonstrating a 
      new route for obtaining 'spatial' organizational adaptability in a self-organized 
      system of interacting components for the incorporation of programmed 
      functionality.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Priyanka
AU  - Priyanka
AD  - Department of Chemical Sciences, Indian Institute of Science Education and 
      Research (IISER) Mohali Knowledge City Manauli 140306 India 
      smaiti@iisermohali.ac.in.
FAU - Shandilya, Ekta
AU  - Shandilya E
AD  - Department of Chemical Sciences, Indian Institute of Science Education and 
      Research (IISER) Mohali Knowledge City Manauli 140306 India 
      smaiti@iisermohali.ac.in.
FAU - Brar, Surinder Kaur
AU  - Brar SK
AD  - Department of Chemical Sciences, Indian Institute of Science Education and 
      Research (IISER) Mohali Knowledge City Manauli 140306 India 
      smaiti@iisermohali.ac.in.
FAU - Mahato, Rishi Ram
AU  - Mahato RR
AD  - Department of Chemical Sciences, Indian Institute of Science Education and 
      Research (IISER) Mohali Knowledge City Manauli 140306 India 
      smaiti@iisermohali.ac.in.
FAU - Maiti, Subhabrata
AU  - Maiti S
AUID- ORCID: 0000-0002-2554-0762
AD  - Department of Chemical Sciences, Indian Institute of Science Education and 
      Research (IISER) Mohali Knowledge City Manauli 140306 India 
      smaiti@iisermohali.ac.in.
LA  - eng
PT  - Journal Article
DEP - 20211122
PL  - England
TA  - Chem Sci
JT  - Chemical science
JID - 101545951
PMC - PMC8694342
COIS- There are no conflicts to declare.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/22 06:01
PMCR- 2021/11/22
CRDT- 2022/01/21 06:20
PHST- 2021/09/28 00:00 [received]
PHST- 2021/11/20 00:00 [accepted]
PHST- 2022/01/21 06:20 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/22 06:01 [medline]
PHST- 2021/11/22 00:00 [pmc-release]
AID - d1sc05353a [pii]
AID - 10.1039/d1sc05353a [doi]
PST - epublish
SO  - Chem Sci. 2021 Nov 22;13(1):274-282. doi: 10.1039/d1sc05353a. eCollection 2021 
      Dec 22.