PMID- 35060638
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20221004
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 56
IP  - 3
DP  - 2022 Sep
TI  - Assessment of Achilles Tendon Changes After Long-Distance Running Using 
      Ultrashort Echo Time Magnetization Transfer MR Imaging.
PG  - 814-823
LID - 10.1002/jmri.28072 [doi]
AB  - BACKGROUND: Long-distance running is a common cause of Achilles tendinopathy. A 
      reliable magnetic resonance imaging (MRI) technique to track early changes in the 
      tendon caused by running could facilitate more effective interventions to combat 
      progression. PURPOSE: To evaluate an ultrashort echo time sequence with 
      magnetization transfer preparation (UTE-MT) in the detection of changes in 
      Achilles tendons of amateur marathon runners before and after long-distance 
      running. STUDY TYPE: Prospective. POPULATION: Thirty-two runners (19 enrolled for 
      full marathons and 13 enrolled for half-marathons) and 5 healthy non-runners. 
      FIELD STRENGTH/SEQUENCE: 3.0 T; UTE-MT and dual-echo UTE for T2* assessment 
      (UTE-T2*). ASSESSMENT: MRI was performed 1-week pre-race, 2-days post-race, and 
      4-weeks post-race. UTE-MT ratio (UTE-MTR) and UTE-T2* of tendon were measured by 
      two independent radiologists who were blinded to the scan time point and 
      participant data. The Achilles tendon was divided into six regions of interest 
      (ROIs) for data analysis, namely the insertion part (INS), middle part (MID), 
      muscle-tendon junction (MTJ), tendon-bone insertion (TBI), tendon-muscle 
      insertion (TMI), and whole tendon (bulk). STATISTICAL TESTS: Analysis of variance 
      and Friedman's rank tests were used to evaluate changes in UTE-MTR and UTE-T2* 
      between time points. Tukey test and Bonferroni method were used for further 
      comparisons. P < 0.05 was considered significant. RESULTS: The UTE-MTR values of 
      most tendon ROIs changed significantly between the measured time points, except 
      for the INS region (P = 0.1977). Conversely, the UTE-T2* values only showed 
      significant changes in the MID and TBI regions. Paired comparisons showed that 
      the UTE-MTR decreases in the MTJ, MID, TMI, and bulk regions at 2-days post-race 
      were significant compared to measures taken pre-race and 4-weeks post-race. For 
      UTE-T2* measurements, significant differences were observed only for the MID 
      region between pre-race and 2-days post-race (P = 0.0408, 95% CI: 0.0061, 
      0.1973), and for the TBI region between pre-race and 4-weeks post-race 
      (P = 0.0473, 95% CI: 0.0013, 0.1766). DATA CONCLUSION: The UTE-MT sequence is 
      able to detect biochemical changes in the Achilles tendon after long-distance 
      running. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY: Stage 1.
CI  - (c) 2022 International Society for Magnetic Resonance in Medicine.
FAU - Fang, Yijie
AU  - Fang Y
AD  - Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, 
      Zhuhai, China.
AD  - Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated 
      Hospital, Sun Yat-sen University, Zhuhai, China.
FAU - Zhu, Dantian
AU  - Zhu D
AD  - Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, 
      Zhuhai, China.
AD  - Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated 
      Hospital, Sun Yat-sen University, Zhuhai, China.
FAU - Wu, Wenhao
AU  - Wu W
AD  - Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, 
      Zhuhai, China.
AD  - Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated 
      Hospital, Sun Yat-sen University, Zhuhai, China.
FAU - Yu, Wenjun
AU  - Yu W
AD  - Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, 
      Zhuhai, China.
AD  - Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated 
      Hospital, Sun Yat-sen University, Zhuhai, China.
FAU - Li, Shaolin
AU  - Li S
AUID- ORCID: 0000-0001-6369-0908
AD  - Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, 
      Zhuhai, China.
AD  - Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated 
      Hospital, Sun Yat-sen University, Zhuhai, China.
FAU - Ma, Ya-Jun
AU  - Ma YJ
AUID- ORCID: 0000-0003-0830-9232
AD  - Department of Radiology, University of California, San Diego, San Diego, 
      California, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220121
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - *Achilles Tendon/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Prospective Studies
MH  - *Running/physiology
MH  - *Tendinopathy/diagnostic imaging
OTO - NOTNLM
OT  - Achilles tendon
OT  - long-distance running
OT  - magnetization transfer
OT  - ultrashort echo time
EDAT- 2022/01/22 06:00
MHDA- 2022/08/17 06:00
CRDT- 2022/01/21 08:58
PHST- 2022/01/06 00:00 [revised]
PHST- 2021/11/18 00:00 [received]
PHST- 2022/01/08 00:00 [accepted]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2022/01/21 08:58 [entrez]
AID - 10.1002/jmri.28072 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2022 Sep;56(3):814-823. doi: 10.1002/jmri.28072. Epub 2022 
      Jan 21.