PMID- 35062871
OWN - NLM
STAT- MEDLINE
DCOM- 20220323
LR  - 20220323
IS  - 1471-2253 (Electronic)
IS  - 1471-2253 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Jan 21
TI  - Unfractionated heparin improves the clinical efficacy in adult sepsis patients: a 
      systematic review and meta-analysis.
PG  - 28
LID - 10.1186/s12871-021-01545-w [doi]
LID - 28
AB  - BACKGROUND: The anticoagulant treatment and clinical efficacy of heparin in 
      sepsis remains controversial. We conducted a meta-analysis to estimate the 
      clinical efficacy of unfractionated heparin (UFH) in adult septic patients. 
      METHOD: A systematic review of Medline, Cochrane Library, PubMed, Embase, WEIPU 
      database, CNKI database, WANFANG database was performed from inception to January 
      2021. We included Randomized controlled trials (RCTs) and the main outcome was 28 
      d mortality. Data analysis was performed with Review Manager (RevMan) version 5.3 
      software. The meta-analysis included 2617 patients from 15 RCTs. RESULTS: 
      Comparing to control group, UFH could reduce 28 d mortality (RR: 0.82; 95% CI: 
      0.72 to 0.94) especially for patient with Acute Physiology and Chronic Health 
      Evaluation II (APACHE II) > 15, (RR: 0.83; 95% CI: 0.72 to 0.96). In UFH group, 
      the platelet (PLT) (MD: 9.18; 95% CI: 0.68 to 17.68) was higher, the activated 
      partial thromboplastin time (APTT) was shorter (MD: -8.01; 95% CI: - 13.84 to 
      - 2.18) and the prothrombin time (PT) results (P > 0.05) failed to reach 
      statistical significance. UFH decreased multiple organ dysfunction syndrome 
      (MODS) incidence (RR: 0.61; 95% CI: 0.45 to 0.84), length of stay (LOS) in ICU 
      (MD: -4.94; 95% CI: - 6.89 to - 2.99) and ventilation time (MD: -3.01; 95% CI: 
      - 4.0 to - 2.02). And UFH had no adverse impact on bleeding (RR: 1.10; 95% CI: 
      0.54 to 2.23). CONCLUSION: This meta-analysis suggests that UFH may reduce 28 d 
      mortality and improve the clinical efficacy in sepsis patients without bleeding 
      adverse effect.
CI  - (c) 2022. The Author(s).
FAU - Fu, Sifeng
AU  - Fu S
AD  - Department of Critical Care Medicine, the First Affiliated Hospital of China 
      Medical University, North Nanjing Street 155, Shenyang, 110000, Liaoning 
      Province, China.
FAU - Yu, Sihan
AU  - Yu S
AD  - Department of Critical Care Medicine, the First Affiliated Hospital of China 
      Medical University, North Nanjing Street 155, Shenyang, 110000, Liaoning 
      Province, China.
FAU - Wang, Liang
AU  - Wang L
AD  - Department of Critical Care Medicine, the First Affiliated Hospital of China 
      Medical University, North Nanjing Street 155, Shenyang, 110000, Liaoning 
      Province, China.
FAU - Ma, Xiaochun
AU  - Ma X
AD  - Department of Critical Care Medicine, the First Affiliated Hospital of China 
      Medical University, North Nanjing Street 155, Shenyang, 110000, Liaoning 
      Province, China.
FAU - Li, Xu
AU  - Li X
AD  - Department of Critical Care Medicine, the First Affiliated Hospital of China 
      Medical University, North Nanjing Street 155, Shenyang, 110000, Liaoning 
      Province, China. vincentzh002@outlook.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20220121
PL  - England
TA  - BMC Anesthesiol
JT  - BMC anesthesiology
JID - 100968535
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Anticoagulants/*therapeutic use
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Sepsis/*drug therapy
MH  - Treatment Outcome
PMC - PMC8777179
OTO - NOTNLM
OT  - Anticoagulant treatment
OT  - Meta-analysis
OT  - Sepsis
OT  - Septic shock
OT  - Unfractionated heparin
COIS- There were no conflicts of interest.
EDAT- 2022/01/23 06:00
MHDA- 2022/03/24 06:00
PMCR- 2022/01/21
CRDT- 2022/01/22 05:31
PHST- 2021/09/03 00:00 [received]
PHST- 2021/12/10 00:00 [accepted]
PHST- 2022/01/22 05:31 [entrez]
PHST- 2022/01/23 06:00 [pubmed]
PHST- 2022/03/24 06:00 [medline]
PHST- 2022/01/21 00:00 [pmc-release]
AID - 10.1186/s12871-021-01545-w [pii]
AID - 1545 [pii]
AID - 10.1186/s12871-021-01545-w [doi]
PST - epublish
SO  - BMC Anesthesiol. 2022 Jan 21;22(1):28. doi: 10.1186/s12871-021-01545-w.