PMID- 35064722
OWN - NLM
STAT- MEDLINE
DCOM- 20220523
LR  - 20220909
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 24
IP  - 5
DP  - 2022 May
TI  - Transapical mitral valve implantation for treatment of symptomatic mitral valve 
      disease: a real-world multicentre experience.
PG  - 899-907
LID - 10.1002/ejhf.2434 [doi]
AB  - AIMS: Transcatheter mitral valve implantation (TMVI) is a new treatment option 
      for patients with symptomatic mitral valve (MV) disease. Real-world data have not 
      yet been reported. This study aimed to assess procedural and 30-day outcomes of 
      TMVI in a real-world patient cohort. METHOD AND RESULTS: All consecutive patients 
      undergoing implantation of a transapically delivered self-expanding valve at 26 
      European centres from January 2020 to April 2021 were included in this 
      retrospective observational registry. Among 108 surgical high-risk patients 
      included (43% female, mean age 75 +/- 7 years, mean STS-PROM 7.2 +/- 5.3%), 25% was 
      treated for an off-label indication (e.g. previous MV intervention or surgery, 
      mitral stenosis, mitral annular calcification). Patients were highly symptomatic 
      (New York Heart Association [NYHA] functional class III/IV in 86%) and mitral 
      regurgitation (MR) was graded 3+/4+ in 95% (38% primary, 37% secondary, and 25% 
      mixed aetiology). Technical success rate was 96%, and MR reduction to </=1+ was 
      achieved in all patients with successful implantation. There were two procedural 
      deaths and 30-day all-cause mortality was 12%. At early clinical follow-up, MR 
      reduction was sustained and there were significant reductions of pulmonary 
      pressure (systolic pulmonary artery pressure 52 vs. 42 mmHg, p < 0.001), and 
      tricuspid regurgitation severity (p = 0.013). Heart failure symptoms improved 
      significantly (73% in NYHA class I/II, p < 0.001). Procedural success rate 
      according to MVARC criteria was 80% and was not different in patients treated for 
      an off-label indication (74% vs. 81% for off- vs. on-label, p = 0.41). 
      CONCLUSION: In a real-world patient population, TMVI has a high technical and 
      procedural success rate with efficient and durable MR reduction and symptomatic 
      improvement.
CI  - (c) 2022 The Authors. European Journal of Heart Failure published by John Wiley & 
      Sons Ltd on behalf of European Society of Cardiology.
FAU - Wild, Mirjam G
AU  - Wild MG
AD  - Medizinische Klinik I, LMU University Hospital, Munich, Germany.
AD  - Department of Cardiology, Inselspital University Hospital Bern, Bern, 
      Switzerland.
FAU - Kreidel, Felix
AU  - Kreidel F
AD  - Department of Cardiology, University Medical Center Mainz, Mainz, Germany.
FAU - Hell, Michaela M
AU  - Hell MM
AD  - Department of Cardiology, University Medical Center Mainz, Mainz, Germany.
FAU - Praz, Fabien
AU  - Praz F
AD  - Department of Cardiology, Inselspital University Hospital Bern, Bern, 
      Switzerland.
FAU - Mach, Markus
AU  - Mach M
AD  - Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
FAU - Adam, Matti
AU  - Adam M
AD  - Department of Cardiology, University Hospital Cologne, Cologne, Germany.
FAU - Reineke, David
AU  - Reineke D
AD  - Department of Cardiac Surgery, Inselspital University Hospital Bern, Bern, 
      Switzerland.
FAU - Ruge, Hendrik
AU  - Ruge H
AD  - Department of Cardiovascular Surgery, German Heart Center, Munich, Technical 
      University Munich, Munich, Germany.
FAU - Ludwig, Sebastian
AU  - Ludwig S
AD  - Department of Cardiology, University Hospital Hamburg, Hamburg, Germany.
FAU - Conradi, Lenard
AU  - Conradi L
AD  - Department of Cardiology, University Hospital Hamburg, Hamburg, Germany.
FAU - Rudolph, Tanja K
AU  - Rudolph TK
AD  - Department of Cardiology, Heart- und Diabetes Center Nordrhine-Westfalia, Bad 
      Oeynhausen, Ruhr-University Bochum, Bochum, Germany.
FAU - Bleiziffer, Sabine
AU  - Bleiziffer S
AD  - Department of Cardiology, Heart- und Diabetes Center Nordrhine-Westfalia, Bad 
      Oeynhausen, Ruhr-University Bochum, Bochum, Germany.
FAU - Kellermair, Jorg
AU  - Kellermair J
AD  - Department of Cardiology, Kepler University Hospital, Linz, Austria.
FAU - Zierer, Andreas
AU  - Zierer A
AD  - Department of Cardiology, Kepler University Hospital, Linz, Austria.
FAU - Nickenig, Georg
AU  - Nickenig G
AD  - Department of Cardiac Surgery, University Hospital Bonn, Bonn, Germany.
FAU - Weber, Marcel
AU  - Weber M
AD  - Department of Cardiology, University Hospital Bonn, Bonn, Germany.
FAU - Petronio, Anna Sonia
AU  - Petronio AS
AD  - Department of Cardiology, Ospedale Universitaria Pisana, Pisa, Italy.
FAU - Giannini, Cristina
AU  - Giannini C
AD  - Department of Cardiology, Ospedale Universitaria Pisana, Pisa, Italy.
FAU - Dahle, Gry
AU  - Dahle G
AD  - Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
FAU - Rein, Kjell A
AU  - Rein KA
AD  - Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
FAU - Coisne, Augustin
AU  - Coisne A
AD  - Universite Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
FAU - Vincentelli, Andre
AU  - Vincentelli A
AD  - Universite Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
FAU - Dubois, Christophe
AU  - Dubois C
AD  - Department of Cardiovascular Medicine Acute and Interventional Cardiology, UZ 
      Leuven, Leuven, Belgium.
FAU - Duncan, Alison
AU  - Duncan A
AD  - Department of Cardiology, Royal Brompton Hospital, London, UK.
FAU - Quarto, Cesare
AU  - Quarto C
AD  - Department of Cardiac Surgery, Royal Brompton Hospital, London, UK.
FAU - Unbehaun, Axel
AU  - Unbehaun A
AD  - Department of Cardiac Surgery, German Heart Center, Berlin, Germany.
FAU - Amat-Santos, Ignacio
AU  - Amat-Santos I
AD  - Department of Cardiology, CIBER-CV, University Clinic Hospital Valladolid, 
      Valladolid, Spain.
FAU - Cobiella, Javier
AU  - Cobiella J
AD  - Department of Cardiology, Hospital Clinico San Carlos, Madrid, Spain.
FAU - Dumonteil, Nicolas
AU  - Dumonteil N
AD  - Department of Cardiology, Clinique Pasteur, Toulouse, France.
FAU - Estevez-Loureiro, Rodrigo
AU  - Estevez-Loureiro R
AD  - Department of Cardiology, University Hospital Alvaro Cunqueiro, Vigo, Spain.
FAU - Fumero, Andrea
AU  - Fumero A
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, 
      Italy; Humanitas Research Hospital IRCCS, Rozzano-Milan, Italy.
FAU - Geisler, Tobias
AU  - Geisler T
AD  - Department of Cardiology, University Hospital Tuebingen, Tuebingen, Germany.
FAU - Lurz, Philipp
AU  - Lurz P
AD  - Department of Cardiology, Heart Center Leipzig, Leipzig, Germany.
FAU - Mangieri, Antonio
AU  - Mangieri A
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, 
      Italy; Humanitas Research Hospital IRCCS, Rozzano-Milan, Italy.
FAU - Monivas, Vanessa
AU  - Monivas V
AD  - Department of Cardiology, Puerta de Hierro Hospital, Madrid, Spain.
FAU - Noack, Thilo
AU  - Noack T
AD  - University Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany.
FAU - Franco, Luis Nombela
AU  - Franco LN
AD  - Department of Cardiology, Hospital Clinico San Carlos, Madrid, Spain.
FAU - Pinon, Miguel A
AU  - Pinon MA
AD  - Department of Cardiology, University Hospital Alvaro Cunqueiro, Vigo, Spain.
FAU - Stolz, Lukas
AU  - Stolz L
AD  - Medizinische Klinik I, LMU University Hospital, Munich, Germany.
FAU - Tchetche, Didier
AU  - Tchetche D
AD  - Department of Cardiology, Clinique Pasteur, Toulouse, France.
FAU - Walter, Thomas
AU  - Walter T
AD  - Department of Cardiac Surgery, University Hospital Frankfurt, Frankfurt, Germany.
FAU - Unsold, Bernhard
AU  - Unsold B
AD  - Department of Internal Medicine II, University Hospital Regensburg, Regensburg, 
      Germany.
FAU - Baldus, Stephan
AU  - Baldus S
AD  - Department of Cardiology, University Hospital Cologne, Cologne, Germany.
FAU - Andreas, Martin
AU  - Andreas M
AD  - Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
FAU - Hausleiter, Jorg
AU  - Hausleiter J
AD  - Medizinische Klinik I, LMU University Hospital, Munich, Germany.
FAU - von Bardeleben, Ralph S
AU  - von Bardeleben RS
AD  - Department of Cardiology, University Medical Center Mainz, Mainz, Germany.
CN  - TENDER Investigators
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20220210
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
CIN - Eur J Heart Fail. 2022 May;24(5):908-909. PMID: 35434899
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Catheterization/methods
MH  - Female
MH  - *Heart Failure/etiology
MH  - *Heart Valve Diseases/etiology
MH  - *Heart Valve Prosthesis
MH  - *Heart Valve Prosthesis Implantation/methods
MH  - Humans
MH  - Male
MH  - Mitral Valve/diagnostic imaging/surgery
MH  - *Mitral Valve Insufficiency
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Mitral regurgitation
OT  - Mitral valve disease
OT  - Tendyne
OT  - Transcatheter mitral valve implantation
EDAT- 2022/01/23 06:00
MHDA- 2022/05/24 06:00
CRDT- 2022/01/22 08:36
PHST- 2021/12/27 00:00 [revised]
PHST- 2021/11/25 00:00 [received]
PHST- 2022/01/10 00:00 [accepted]
PHST- 2022/01/23 06:00 [pubmed]
PHST- 2022/05/24 06:00 [medline]
PHST- 2022/01/22 08:36 [entrez]
AID - 10.1002/ejhf.2434 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2022 May;24(5):899-907. doi: 10.1002/ejhf.2434. Epub 2022 Feb 
      10.