PMID- 35064941
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20230402
IS  - 1523-4681 (Electronic)
IS  - 0884-0431 (Print)
IS  - 0884-0431 (Linking)
VI  - 37
IP  - 4
DP  - 2022 Apr
TI  - Distributions of Microdamage Are Altered Between Trabecular Rods and Plates in 
      Cancellous Bone From Men With Type 2 Diabetes Mellitus.
PG  - 740-752
LID - 10.1002/jbmr.4509 [doi]
AB  - Individuals with type 2 diabetes mellitus (T2DM) have an increased risk of 
      fragility fracture despite exhibiting normal to high bone mineral density (BMD). 
      Conditions arising from T2DM, such as reduced bone turnover and alterations in 
      microarchitecture, may contribute to skeletal fragility by influencing bone 
      morphology and microdamage accumulation. The objectives of this study were (i) to 
      characterize the effect of T2DM on microdamage quantity and morphology in 
      cancellous bone, and (ii) relate the accumulation of microdamage to the 
      cancellous microarchitecture. Cancellous specimens from the femoral neck were 
      collected during total hip arthroplasty (T2DM: n = 22, age = 65 +/- 9 years, 
      glycated hemoglobin [HbA1c] = 7.00% +/- 0.98%; non-diabetic [non-DM]: n = 25, 
      age = 61 +/- 8 years, HbA1c = 5.50% +/- 0.4%), compressed to 3% strain, stained with 
      lead uranyl acetate to isolate microdamage, and scanned with micro-computed 
      tomography (muCT). Individual trabeculae segmentation was used to isolate rod-like 
      and plate-like trabeculae and their orientations with respect to the loading 
      axis. The T2DM group trended toward a greater BV/TV (+27%, p = 0.07) and had a 
      more plate-like trabecular architecture (+8% BV(plates) , p = 0.046) versus 
      non-DM specimens. Rods were more damaged relative to their volume compared to 
      plates in the non-DM group (DV(rods) /BV(rods) versus DV(plates) /BV(plates) : 
      +49%, p < 0.0001), but this difference was absent in T2DM specimens. Longitudinal 
      rods were more damaged in the non-DM group (DV(longitudinal rods) 
      /BV(longitudinal rods) : +73% non-DM versus T2DM, p = 0.027). Total damage 
      accumulation (DV/BV) and morphology (DS/DV) did not differ in T2DM versus non-DM 
      specimens. These results provide evidence that cancellous microarchitecture does 
      not explain fracture risk in T2DM, pointing to alterations in material matrix 
      properties. In particular, cancellous bone from men with T2DM may have an 
      attenuated ability to mitigate microdamage accumulation through sacrificial rods. 
      (c) 2022 American Society for Bone and Mineral Research (ASBMR).
CI  - (c) 2022 American Society for Bone and Mineral Research (ASBMR).
FAU - Sacher, Sara E
AU  - Sacher SE
AUID- ORCID: 0000-0001-8410-1500
AD  - Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 
      USA.
FAU - Hunt, Heather B
AU  - Hunt HB
AD  - Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 
      USA.
FAU - Lekkala, Sashank
AU  - Lekkala S
AD  - Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 
      USA.
FAU - Lopez, Kelsie A
AU  - Lopez KA
AD  - Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 
      USA.
FAU - Potts, Jesse
AU  - Potts J
AD  - Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 
      USA.
FAU - Heilbronner, Alison K
AU  - Heilbronner AK
AD  - Department of Medicine, Endocrinology and Metabolic Bone Service, Hospital for 
      Special Surgery, New York, NY, USA.
FAU - Stein, Emily M
AU  - Stein EM
AUID- ORCID: 0000-0002-1463-5774
AD  - Department of Medicine, Endocrinology and Metabolic Bone Service, Hospital for 
      Special Surgery, New York, NY, USA.
FAU - Hernandez, Christopher J
AU  - Hernandez CJ
AUID- ORCID: 0000-0002-0712-6533
AD  - Research Division, Hospital for Special Surgery, New York, NY, USA.
AD  - Sibley School of Mechanical and Aerospace Engineering, Cornell University, 
      Ithaca, NY, USA.
FAU - Donnelly, Eve
AU  - Donnelly E
AUID- ORCID: 0000-0001-8165-9568
AD  - Department of Materials Science and Engineering, Cornell University, Ithaca, NY, 
      USA.
AD  - Research Division, Hospital for Special Surgery, New York, NY, USA.
LA  - eng
GR  - K01 AR064314/AR/NIAMS NIH HHS/United States
GR  - R01 AG067997/AG/NIA NIH HHS/United States
GR  - R21 AR073454/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220215
PL  - England
TA  - J Bone Miner Res
JT  - Journal of bone and mineral research : the official journal of the American 
      Society for Bone and Mineral Research
JID - 8610640
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Aged
MH  - Bone Density
MH  - *Cancellous Bone/diagnostic imaging
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Femur Neck/diagnostic imaging
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - X-Ray Microtomography
PMC - PMC9833494
MID - NIHMS1852903
OTO - NOTNLM
OT  - BIOMECHANICS
OT  - BONE MATRIX
OT  - BONE muCT
OT  - DISEASES OF BONE - OTHER (TYPE 2 DIABETES)
OT  - MATRIX MINERALIZATION
EDAT- 2022/01/23 06:00
MHDA- 2022/04/20 06:00
PMCR- 2023/04/01
CRDT- 2022/01/22 12:07
PHST- 2022/01/07 00:00 [revised]
PHST- 2021/07/31 00:00 [received]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/01/23 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
PHST- 2022/01/22 12:07 [entrez]
PHST- 2023/04/01 00:00 [pmc-release]
AID - 10.1002/jbmr.4509 [doi]
PST - ppublish
SO  - J Bone Miner Res. 2022 Apr;37(4):740-752. doi: 10.1002/jbmr.4509. Epub 2022 Feb 
      15.