PMID- 35065939 OWN - NLM STAT- MEDLINE DCOM- 20220401 LR - 20230613 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 209 DP - 2022 Jun TI - The associations of prenatal exposure to dioxins and polychlorinated biphenyls with neurodevelopment at 6 Months of age: Multi-pollutant approaches. PG - 112757 LID - S0013-9351(22)00084-6 [pii] LID - 10.1016/j.envres.2022.112757 [doi] AB - BACKGROUND: Prenatal exposure to persistent organic pollutants, including polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), dioxin-like polychlorinated biphenyls (DL-PCBs), and nondioxin-like PCBs (NDL-PCBs), has been hypothesized to have a detrimental impact on neurodevelopment. However, the association of prenatal exposure to a dioxin and PCB mixture with neurodevelopment remains largely inconclusive partly because these chemical levels are correlated. OBJECTIVES: We aimed to elucidate the association of in utero exposure to a mixture of dioxins and PCBs with neurodevelopment measured at 6 months of age by applying multipollutant methods. METHODS: A total of 514 pregnant women were recruited between July 2002 and October 2005 in the Sapporo cohort, Hokkaido Study on Environment and Children's Health. The concentrations of individual dioxin and PCB isomers were assessed in maternal peripheral blood during pregnancy. The mental and psychomotor development of the study participants' infants was evaluated using the Bayley Scales of Infant Development-2nd Edition (n = 259). To determine both the joint and individual associations of prenatal exposure to a dioxin and PCB mixture with infant neurodevelopment, Bayesian kernel machine regression (BKMR) and quantile-based g-computation were employed. RESULTS: Suggestive inverse associations were observed between in utero exposure to a dioxin and PCB mixture and infant psychomotor development in both the BKMR and quantile g-computation models. In contrast, we found no association of a dioxin and PCB mixture with mental development. When group-specific posterior inclusion probabilities were estimated, BKMR suggested prenatal exposure to mono-ortho PCBs as the more important contributing factors to early psychomotor development compared with the other dioxin or PCB groups. No evidence of nonlinear exposure-outcome relationships or interactions among the chemical mixtures was detected. CONCLUSIONS: Applying the two complementary statistical methods for chemical mixture analysis, we demonstrated limited evidence of inverse associations of prenatal exposure to dioxins and PCBs with infant psychomotor development. CI - Copyright (c) 2022 Elsevier Inc. All rights reserved. FAU - Yim, Gyeyoon AU - Yim G AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Minatoya, Machiko AU - Minatoya M AD - Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan. FAU - Kioumourtzoglou, Marianthi-Anna AU - Kioumourtzoglou MA AD - Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA. FAU - Bellavia, Andrea AU - Bellavia A AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Weisskopf, Marc AU - Weisskopf M AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Ikeda-Araki, Atsuko AU - Ikeda-Araki A AD - Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan; Hokkaido University Faculty of Health Sciences, Kita 12, Nishi 5, Kita-ku, Sapporo, 060-0812, Japan. FAU - Miyashita, Chihiro AU - Miyashita C AD - Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan. FAU - Kishi, Reiko AU - Kishi R AD - Hokkaido University Center for Environmental and Health Sciences, Kita 12, Nishi 7, Kita-ku, Sapporo, 060-0812, Japan. Electronic address: rkishi@med.hokudai.ac.jp. LA - eng GR - P30 ES000002/ES/NIEHS NIH HHS/United States GR - P30 ES009089/ES/NIEHS NIH HHS/United States GR - R01 ES028805/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20220120 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Dibenzofurans, Polychlorinated) RN - 0 (Dioxins) RN - 0 (Environmental Pollutants) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Bayes Theorem MH - Dibenzofurans, Polychlorinated MH - *Dioxins/toxicity MH - *Environmental Pollutants/analysis/toxicity MH - Female MH - Humans MH - Infant MH - Maternal Exposure/adverse effects MH - *Polychlorinated Biphenyls/toxicity MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/chemically induced/epidemiology PMC - PMC10259612 MID - NIHMS1903293 OTO - NOTNLM OT - Bayesian kernel machine regression OT - Bayley scales of infant development OT - Birth cohort study OT - Chemical mixtures OT - Child health OT - Dioxins OT - Neurological development OT - Persistent organic pollutants OT - Polychlorinated biphenyls OT - Polychlorinated dibenzo-p-dioxins OT - Polychlorinated dibenzofurans OT - Prenatal exposure OT - Quantile g-computation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/01/24 06:00 MHDA- 2022/04/02 06:00 PMCR- 2023/06/12 CRDT- 2022/01/23 20:29 PHST- 2021/08/30 00:00 [received] PHST- 2022/01/14 00:00 [revised] PHST- 2022/01/15 00:00 [accepted] PHST- 2022/01/24 06:00 [pubmed] PHST- 2022/04/02 06:00 [medline] PHST- 2022/01/23 20:29 [entrez] PHST- 2023/06/12 00:00 [pmc-release] AID - S0013-9351(22)00084-6 [pii] AID - 10.1016/j.envres.2022.112757 [doi] PST - ppublish SO - Environ Res. 2022 Jun;209:112757. doi: 10.1016/j.envres.2022.112757. Epub 2022 Jan 20.