PMID- 35066749
OWN - NLM
STAT- MEDLINE
DCOM- 20221028
LR  - 20221028
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 200
IP  - 11
DP  - 2022 Nov
TI  - Possible Association Between Polymorphisms in ESR1, COL1A2, BGLAP, SPARC, VDR, 
      and MMP2 Genes and Dental Fluorosis in a Population from an Endemic Region of 
      West Bengal.
PG  - 4641-4653
LID - 10.1007/s12011-021-03072-8 [doi]
AB  - Dental fluorosis (DF) is the most prevalent form of fluorosis in India affecting 
      millions of people all over the country. As estrogen receptor 1 (ESR1), collagen 
      type 1 alpha 2 (COL1A2), bone gamma-carboxyglutamic acid protein (BGLAP), secreted 
      protein acidic and cysteine-rich (SPARC), vitamin D receptor (VDR), and matrix 
      metallopeptidase 2 (MMP2) genes play critical roles in bone metabolism, bone 
      formation, mineral metabolism, and mineralization, variants in these genes could 
      influence susceptibility to DF. The present study was aimed at evaluating the 
      association between 15 single-nucleotide polymorphisms (SNPs) in the six 
      candidate genes (namely, ESR1, COL1A2, BGLAP, SPARC, VDR, and MMP2) and DF among 
      132 individuals (case = 71 and control = 61) living in a fluoride endemic region 
      of West Bengal, India. No statistically significant association with disease risk 
      was found when the genotypes and allele frequencies of each of the 15 SNPs was 
      analyzed individually using odd's ratio with 95% confidence interval. "CC" and 
      "AG" haplotypes of the COL1A2 gene showed a borderline association with DF. The 
      present study is the first in India to use multifactor dimensionality reduction 
      (MDR) analysis for identifying gene-gene and gene-environment interactions in 
      fluorosis. The biomarker of serum fluoride showed a significant association with 
      the disease state among the 17 attributes (15 SNPs and 2 biomarkers of urine 
      fluoride and serum fluoride) (P value = 0.011). The best model of MDR analysis 
      with maximized testing accuracy involved two SNPs from the ESR1 gene (rs9340799 
      and rs2077647) and one SNP from BGLAP gene (rs1543294) (P value < 0.0001).
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Chakraborty, Arijit
AU  - Chakraborty A
AD  - Kolkata Zonal Centre, CSIR-National Environmental Engineering Research Institute, 
      i-8 Sector-C, East Kolkata Township, Kolkata, 700107, India.
FAU - Pramanik, Sreemanta
AU  - Pramanik S
AUID- ORCID: 0000-0003-0448-2118
AD  - Kolkata Zonal Centre, CSIR-National Environmental Engineering Research Institute, 
      i-8 Sector-C, East Kolkata Township, Kolkata, 700107, India. sreemanta@gmail.com.
FAU - Datta, Kallol
AU  - Datta K
AD  - National Institute of Biomedical Genomics, P.O. N.S.S., Kalyani, 741251, West 
      Bengal, India.
FAU - Goswami, Rakesh
AU  - Goswami R
AD  - Kolkata Zonal Centre, CSIR-National Environmental Engineering Research Institute, 
      i-8 Sector-C, East Kolkata Township, Kolkata, 700107, India.
FAU - Saha, Depanwita
AU  - Saha D
AD  - Kolkata Zonal Centre, CSIR-National Environmental Engineering Research Institute, 
      i-8 Sector-C, East Kolkata Township, Kolkata, 700107, India.
FAU - Majumdar, Kunal Kanti
AU  - Majumdar KK
AD  - Department of Community Medicine, KPC Medical College and Hospital, 1F Raja S. C. 
      Mullick Road, Jadavpur, Kolkata, 700032, India.
FAU - Sikdar, Nilabja
AU  - Sikdar N
AD  - Human Genetics Unit, Indian Statistical Institute, 203 B. T. Road, Baranagar, 
      Kolkata, 700108, India.
LA  - eng
GR  - Project No. BT/PR8283/MED/12/619/2013/Department of Biotechnology , Ministry of 
      Science and Technology/
PT  - Journal Article
DEP - 20220123
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (COL1A2 protein, human)
RN  - 0 (Collagen Type I, alpha2 Subunit)
RN  - K848JZ4886 (Cysteine)
RN  - 0 (Estrogen Receptor alpha)
RN  - Q80VPU408O (Fluorides)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - 0 (Minerals)
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - 104982-03-8 (Osteocalcin)
RN  - 0 (Osteonectin)
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (SPARC protein, human)
RN  - 0 (VDR protein, human)
RN  - 0 (BGLAP protein, human)
SB  - IM
MH  - Humans
MH  - Cysteine
MH  - Estrogen Receptor alpha/genetics
MH  - Fluorides
MH  - *Fluorosis, Dental/epidemiology/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Matrix Metalloproteinase 2/genetics
MH  - Minerals
MH  - Osteocalcin/genetics
MH  - Osteonectin/genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - *Receptors, Calcitriol/genetics
OTO - NOTNLM
OT  - Biomarker
OT  - Candidate gene
OT  - Dental fluorosis
OT  - Genetic association
OT  - Haplotype
OT  - Multifactor dimensionality reduction
EDAT- 2022/01/24 06:00
MHDA- 2022/09/24 06:00
CRDT- 2022/01/23 20:38
PHST- 2021/11/10 00:00 [received]
PHST- 2021/12/15 00:00 [accepted]
PHST- 2022/01/24 06:00 [pubmed]
PHST- 2022/09/24 06:00 [medline]
PHST- 2022/01/23 20:38 [entrez]
AID - 10.1007/s12011-021-03072-8 [pii]
AID - 10.1007/s12011-021-03072-8 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2022 Nov;200(11):4641-4653. doi: 10.1007/s12011-021-03072-8. 
      Epub 2022 Jan 23.