PMID- 35066900
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20220531
IS  - 1521-186X (Electronic)
IS  - 0197-8462 (Linking)
VI  - 43
IP  - 2
DP  - 2022 Feb
TI  - Effects of Acute Exposure to 3500 MHz (5G) Radiofrequency Electromagnetic 
      Radiation on Anxiety-Like Behavior and the Auditory Cortex in Guinea Pigs.
PG  - 106-118
LID - 10.1002/bem.22388 [doi]
AB  - Numerous studies have shown that radiofrequency electromagnetic radiation 
      (RF-EMR) may negatively affect human health. We detected the effect of 3500 MHz 
      RF-EMR on anxiety-like behavior and the auditory cortex (ACx) in guinea pigs. 
      Forty male guinea pigs were randomly divided into four groups and exposed to a 
      continuous wave of 3500 MHz RF-EMF at an average specific absorption rate (SAR) 
      of 0, 2, 4, or 10 W/kg for 72 h. After exposure, malondialdehyde (MDA) levels, 
      antioxidant enzyme activity, anxiety-like behavior, hearing thresholds, cell 
      ultrastructure, and apoptosis were detected. Our results revealed that hearing 
      thresholds and basic indexes of animal behavior did not change significantly 
      after exposure (P > 0.05). However, the MDA levels of ACx were increased 
      (P < 0.05), and catalase (CAT), superoxide dismutase (SOD), and glutathione 
      peroxidase (GSH-px) activities were decreased (P < 0.05) in the exposure groups 
      compared to the sham group. Ultrastructural changes of ACx, including swollen 
      mitochondria and layered myelin sheaths, were observed. Cytochrome-c 
      relocalization, caspase-9, and cleaved caspase-3 activation were detected in the 
      exposure groups. In conclusion, these results suggest that oxidative stress is an 
      important mechanism underlying the biological effects of RF-EMR, which can induce 
      ultrastructural damage to the ACx and cell apoptosis through a 
      mitochondria-dependent mechanism. Moreover, oxidative stress, apoptosis induction 
      and ultrastructural damage increase in a SAR-dependent manner. However, RF-EMR 
      does not increase hearing thresholds or induce anxiety. Bioelectromagnetics. 
      43:106-118, 2022. (c) 2021 Bioelectromagnetics Society.
CI  - (c) 2021 Bioelectromagnetics Society.
FAU - Yang, Honghong
AU  - Yang H
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Zhang, Yuanyuan
AU  - Zhang Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan 
      University, Wuhan, Hubei, China.
FAU - Wu, Xianwen
AU  - Wu X
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Gan, Ping
AU  - Gan P
AD  - Department of Dependable Service Computing in Cyber Physical Society, Key 
      Laboratory of the Ministry of Education, Chongqing University, Chongqing, China.
FAU - Luo, Xiaoli
AU  - Luo X
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Zhong, Shixun
AU  - Zhong S
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
FAU - Zuo, Wenqi
AU  - Zuo W
AUID- ORCID: 0000-0002-1109-3500
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing, China.
LA  - eng
GR  - 20180105/The Foundation and Frontier Research Project, Science and Technology 
      Commission, Yuzhong District, Chongqing, China/
GR  - 81700916/The National Nature Science Foundation of China/
GR  - KJQN201900433/The Science and Technology Research Program of Chongqing Municipal 
      Education Commission/
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
DEP - 20220123
PL  - United States
TA  - Bioelectromagnetics
JT  - Bioelectromagnetics
JID - 8008281
RN  - 0 (Antioxidants)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Anxiety/etiology
MH  - *Auditory Cortex/metabolism
MH  - *Cell Phone
MH  - Electromagnetic Fields/adverse effects
MH  - Electromagnetic Radiation
MH  - Guinea Pigs
MH  - Male
MH  - Oxidative Stress
OTO - NOTNLM
OT  - anxiety-like behavior
OT  - apoptosis
OT  - auditory cortex
OT  - oxidative stress
OT  - radiofrequency electromagnetic radiation
EDAT- 2022/01/24 06:00
MHDA- 2022/01/28 06:00
CRDT- 2022/01/23 20:38
PHST- 2021/09/26 00:00 [revised]
PHST- 2020/12/04 00:00 [received]
PHST- 2022/01/05 00:00 [accepted]
PHST- 2022/01/24 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
PHST- 2022/01/23 20:38 [entrez]
AID - 10.1002/bem.22388 [doi]
PST - ppublish
SO  - Bioelectromagnetics. 2022 Feb;43(2):106-118. doi: 10.1002/bem.22388. Epub 2022 
      Jan 23.