PMID- 35067699
OWN - NLM
STAT- MEDLINE
DCOM- 20220317
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 26
IP  - 1
DP  - 2022
TI  - Intrinsic Capacity Defined Using Four Domains and Mortality Risk: A 5-Year 
      Follow-Up of the SarcoPhAge Cohort.
PG  - 23-29
LID - 10.1007/s12603-021-1702-7 [doi]
AB  - OBJECTIVES: The concept of 'intrinsic capacity' (IC) offers a new way to approach 
      another concept, that of 'healthy aging'. The first objective of the present 
      study was to assess the ability of the construct of 'intrinsic capacity' to 
      predict death. The second objective was to assess whether deteriorations in 
      intrinsic capacity, measured over 1 and 2 years, are predictive of death. DESIGN: 
      The present analysis was based on a prospective cohort study. SETTING: 
      Community-dwelling participants. PARTICIPANTS: The study recruited older adults 
      aged 65 years and older. MEASUREMENTS: Intrinsic capacity (IC) encompasses five 
      domains: sensorial (not evaluated here), cognition (Mini-Mental State 
      Examination), nutrition (Mini-Nutritional Assessment), mobility (Short Physical 
      Performance Battery), and psychological (Geriatric Depression Scale). Each domain 
      was considered satisfactory when its assessment, for an individual, was above the 
      threshold defined by the initial validation of the domain assessment tool. To 
      explore the relationship between IC and mortality risk, a Cox model was applied. 
      The predictive value of the dynamic aspects (i.e., changes over 1 year and 2 
      years) was investigated using the following categorization of IC: stable, 
      deteriorated, improved. RESULTS: The sample was composed of 481 volunteers aged 
      73.4+/-6.12 years (60.1% women). Two satisfactory IC domains appeared to be 
      significantly associated with reduced mortality risk: the satisfactory mobility 
      domain (adjusted HR=0.45 [0.26-0.79]) and the satisfactory psychological domain 
      (adjusted HR = 0.56 [1.04-3.09]). When considering intrinsic capacity as a whole 
      construct, using a composite Z-score, we noticed that the risk of death was 
      decreased by 49% for an increase of 1 standard deviation in IC. Changes in 
      intrinsic capacity in the mobility and psychological domains led to an increased 
      risk of death (from 2.74 to 4.18-fold). CONCLUSION: The concept of intrinsic 
      capacity seems highly relevant in order to assess older adults' health and 
      well-being. This concept should be considered for integration into clinical 
      practice.
FAU - Locquet, M
AU  - Locquet M
AD  - Medea Locquet, M.Sc., PhD, CHU de Liege, Avenue Hippocrate 13, 4000 Liege, 
      Belgium, 003243662519, medea.locquet@gmail.com.
FAU - Sanchez-Rodriguez, D
AU  - Sanchez-Rodriguez D
FAU - Bruyere, O
AU  - Bruyere O
FAU - Geerinck, A
AU  - Geerinck A
FAU - Lengele, L
AU  - Lengele L
FAU - Reginster, J-Y
AU  - Reginster JY
FAU - Beaudart, C
AU  - Beaudart C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - *Geriatric Assessment
MH  - Humans
MH  - *Independent Living
MH  - Male
MH  - Prospective Studies
OTO - NOTNLM
OT  - Healthy Ageing
OT  - World Health Organization
OT  - epidemiology
COIS- All the authors declare no conflict of interest.
EDAT- 2022/01/25 06:00
MHDA- 2022/03/18 06:00
CRDT- 2022/01/24 05:49
PHST- 2022/01/24 05:49 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/03/18 06:00 [medline]
AID - S1279-7707(23)00897-7 [pii]
AID - 10.1007/s12603-021-1702-7 [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2022;26(1):23-29. doi: 10.1007/s12603-021-1702-7.