PMID- 35067700
OWN - NLM
STAT- MEDLINE
DCOM- 20220317
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 26
IP  - 1
DP  - 2022
TI  - Towards Healthy Ageing: Using the Concept of Intrinsic Capacity in Frailty 
      Prevention.
PG  - 30-36
LID - 10.1007/s12603-021-1715-2 [doi]
AB  - OBJECTIVES: To examine whether intrinsic capacity (IC) could predict frailty, 
      whether declines in specific domains of IC could lead to frailty, and whether 
      different combinations of domains could represent different risks of developing 
      frailty. SETTING: Community. PARTICIPANTS: Chinese people aged 65 years and 
      older. MEASUREMENTS: Using data from a prospective cohort study, we derived a 
      summary score for IC and scores for the five domains (cognitive, locomotor, 
      vitality, sensory, psychological) for each participant at baseline. Frailty was 
      assessed according to the Fried's frailty phenotype at baseline, 2- and 4-year 
      follow-ups. Participants were classified as frail if they had >/=3 of the following 
      criteria: weight loss, self-rated exhaustion, weakness, slow walking speed, and 
      low physical activity. RESULTS: Four thousand participants were interviewed at 
      baseline. Overall mean age was 72.5 years; 50% were women. Between baseline and 
      the 2-year follow-up, 5.7% of non-frail participants developed frailty; between 
      2- and 4-year follow-ups, 5.7% of non-frail participants developed frailty. The 
      average annual incidence rate of frailty was 2.9%. Higher scores on IC at 
      baseline were associated with a lower risk of incident frailty at both follow-ups 
      (year 2, odds ratio (OR)=0.64, 95% confidence interval (CI)=0.59-0.71); year 4, 
      OR=0.64, 95%CI=0.58-0.71) after adjustment for age, sex, educational level, and 
      chronic diseases. Across the five domains, vitality was the strongest predictor 
      of incident frailty at each follow-up (year 2, OR=0.33, 95%CI=0.24-0.45; year 4, 
      OR=0.33, 95%CI=0.23-0.46). Compared to other combinations of any two domains, 
      having 'high' scores on both vitality and locomotor domains was associated with 
      the lowest risk of incident frailty (year 2, OR=0.11, 95%CI=0.06-0.22, area under 
      the curve (AUC)=0.770; year 4, OR=0.18, 95%CI=0.10-0.32, AUC=0.782). CONCLUSION: 
      This study provides evidence that IC was independently associated with incident 
      frailty. It also finds that vitality was the domain most strongly associated with 
      incident frailty. Finally, it suggests that optimizing multiple domains of IC, 
      particularly vitality and locomotor, may prevent frailty.
FAU - Yu, R
AU  - Yu R
AD  - Ruby Yu, Department of Medicine and Therapeutics, Faculty of Medicine, The 
      Chinese University of Hong Kong, Hong Kong, China, rubyyu@cuhk.edu.hk.
FAU - Leung, J
AU  - Leung J
FAU - Leung, G
AU  - Leung G
FAU - Woo, J
AU  - Woo J
LA  - eng
GR  - R01 AR049439/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
SB  - IM
MH  - Aged
MH  - Female
MH  - Frail Elderly/psychology
MH  - *Frailty/epidemiology/prevention & control
MH  - *Healthy Aging
MH  - Humans
MH  - Incidence
MH  - Prospective Studies
OTO - NOTNLM
OT  - Frailty
OT  - ICOPE
OT  - healthy ageing
OT  - incidence
OT  - intrinsic capacity
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/01/25 06:00
MHDA- 2022/03/18 06:00
CRDT- 2022/01/24 05:49
PHST- 2022/01/24 05:49 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/03/18 06:00 [medline]
AID - S1279-7707(23)00898-9 [pii]
AID - 10.1007/s12603-021-1715-2 [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2022;26(1):30-36. doi: 10.1007/s12603-021-1715-2.