PMID- 35067798
OWN - NLM
STAT- MEDLINE
DCOM- 20230926
LR  - 20230926
IS  - 1613-2254 (Electronic)
IS  - 1346-4523 (Print)
IS  - 1346-4523 (Linking)
VI  - 49
IP  - 2
DP  - 2022 Apr
TI  - Promoting the effect of microbubble-enhanced ultrasound on hyperthermia in rabbit 
      liver.
PG  - 133-142
LID - 10.1007/s10396-021-01187-y [doi]
AB  - PURPOSE: The heat-sink effect is one reason for the insufficient temperature 
      increase in hyperthermia (HT) treatment for cancer. Microbubbles (MBs) nucleate 
      inertial cavitation under therapeutic ultrasound (TUS) exposure, which form 
      microbubble-enhanced ultrasound (MEUS), which results in blocking blood perfusion 
      in the targeted liver tissues. This study aimed to determine if synergistic 
      effects exist during HT in the liver when combined with MEUS. METHODS: Forty 
      rabbits with surgically exposed livers were randomly divided into TUS + MB + HT, 
      MB + HT, normal saline + HT, and MB + sham groups (n = 10 in each group). Liver 
      perfusion was evaluated using contrast-enhanced ultrasound. The temperatures of 
      the liver tissues were monitored using thermocouples. Pathological changes were 
      determined by hematoxylin and eosin (H&E) staining. Serum hepatic transaminases 
      were evaluated. RESULTS: MEUS pretreatment almost completely blocked the 
      perfusion of targeted areas. The TUS + MB + HT and MB + HT groups showed 
      significantly higher temperatures in treated areas than those in the other 
      groups. However, the TUS + MB + HT group exhibited a more stable and regular 
      increase in temperatures in the fitting curves compared with the MB + HT group. 
      H&E staining revealed swelling hepatocytes, hemorrhage, and thrombosis in the 
      portal area in the TUS + MB + HT group. CONCLUSION: MEUS reduced the blood 
      perfusion in the targeted liver tissues, and, therefore, overcame the heat-sink 
      effect during the HT procedure in rabbits. MEUS pretreatment might have the 
      potential to enhance the therapeutic effect of HT.
CI  - (c) 2022. The Author(s).
FAU - Yang, Yuwen
AU  - Yang Y
AD  - The First Affiliated Hospital of Jinan University, Guangzhou, China.
AD  - Department of Medical Ultrasound, Guangzhou First People's Hospital, School of 
      Medicine, South China University of Technology, Guangzhou, China.
FAU - Luo, Huanqian
AU  - Luo H
AD  - Department of Medical Ultrasound, Dongguan People's Hospital, Southern Medical 
      University, Dongguan, China.
FAU - Zhao, Yang
AU  - Zhao Y
AD  - Department of Ultrasound, Xinqiao Hospital, Chongqing, China.
FAU - Li, Lu
AU  - Li L
AD  - Department of Ultrasound, Xinqiao Hospital, Chongqing, China.
FAU - He, Yan
AU  - He Y
AD  - Department of Medical Ultrasound, Guangzhou First People's Hospital, School of 
      Medicine, South China University of Technology, Guangzhou, China.
FAU - Xi, Fen
AU  - Xi F
AD  - Department of Medical Ultrasound, Guangzhou First People's Hospital, School of 
      Medicine, South China University of Technology, Guangzhou, China.
FAU - Jin, Hai
AU  - Jin H
AD  - Department of Medical Ultrasound, Guangzhou First People's Hospital, School of 
      Medicine, South China University of Technology, Guangzhou, China.
FAU - Gao, Ruru
AU  - Gao R
AD  - Department of Medical Ultrasound, Guangzhou First People's Hospital, School of 
      Medicine, South China University of Technology, Guangzhou, China.
FAU - Luo, Qiong
AU  - Luo Q
AD  - Department of Medical Ultrasound, Guangzhou First People's Hospital, School of 
      Medicine, South China University of Technology, Guangzhou, China.
FAU - Liu, Jianhua
AU  - Liu J
AUID- ORCID: 0000-0001-8628-0127
AD  - The First Affiliated Hospital of Jinan University, Guangzhou, China. 
      liujianhua266@163.com.
AD  - Department of Medical Ultrasound, Guangzhou First People's Hospital, School of 
      Medicine, South China University of Technology, Guangzhou, China. 
      liujianhua266@163.com.
LA  - eng
GR  - 82071935/National Natural Science Foundation of China/
GR  - 20201A010008/Guangzhou General Science and Technology Project of Health and 
      Family Planning/
GR  - 20130319c/Guangdong Planned Project of Science and Technology, China/
PT  - Journal Article
DEP - 20220124
PL  - Japan
TA  - J Med Ultrason (2001)
JT  - Journal of medical ultrasonics (2001)
JID - 101128385
SB  - IM
MH  - Animals
MH  - Rabbits
MH  - Liver/pathology
MH  - *Microbubbles
MH  - *Ultrasonic Therapy/methods
MH  - Ultrasonography/methods
PMC - PMC9038817
OTO - NOTNLM
OT  - Cavitation
OT  - Hyperthermia
OT  - Liver
OT  - Microbubble
OT  - Microbubble-enhanced ultrasound
COIS- The authors declare no conflicts of interest.
EDAT- 2022/01/25 06:00
MHDA- 2022/04/28 06:00
PMCR- 2022/01/24
CRDT- 2022/01/24 05:49
PHST- 2021/03/26 00:00 [received]
PHST- 2021/11/22 00:00 [accepted]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/04/28 06:00 [medline]
PHST- 2022/01/24 05:49 [entrez]
PHST- 2022/01/24 00:00 [pmc-release]
AID - 10.1007/s10396-021-01187-y [pii]
AID - 1187 [pii]
AID - 10.1007/s10396-021-01187-y [doi]
PST - ppublish
SO  - J Med Ultrason (2001). 2022 Apr;49(2):133-142. doi: 10.1007/s10396-021-01187-y. 
      Epub 2022 Jan 24.