PMID- 35067831
OWN - NLM
STAT- MEDLINE
DCOM- 20220429
LR  - 20240211
IS  - 1573-3254 (Electronic)
IS  - 1090-7165 (Print)
IS  - 1090-7165 (Linking)
VI  - 26
IP  - 6
DP  - 2022 Jun
TI  - Sauti ya Vijana (SYV; The Voice of Youth): Longitudinal Outcomes of an 
      Individually Randomized Group Treatment Pilot Trial for Young People Living with 
      HIV in Tanzania.
PG  - 2015-2025
LID - 10.1007/s10461-021-03550-z [doi]
AB  - Sauti ya Vijana is a mental health and life skills intervention delivered by 
      young adult group leaders for the improvement of HIV outcomes in young people 
      living with HIV in Tanzania. This pilot randomized controlled trial estimated 
      exploratory intervention effectiveness compared to standard of care. YPLWH 
      (N = 105) were randomized to receive intervention or SOC. The mean age of 
      participants was 18.1 years and 53% were female. Mean scores on mental health 
      measures (Patient Health Questionnaire [PHQ-9], Strengths and Difficulties 
      Questionnaire [SDQ], UCLA Trauma) were asymptomatic to mild in both study arms 
      through 30-month follow-up with a non-significant fluctuation of 1-2 points. The 
      mean self-reported adherence was higher in the intervention arm across all time 
      points (but the confidence interval contained the null at all time points except 
      6 months). Risk ratio of virologic suppression (HIV RNA < 400 copies/mL) in the 
      intervention arm compared to SOC was 1.15 [95% CI = 0.95, 1.39]) at 6-months, 
      1.17 [95% CI: 0.92, 1.48] at 12-months, and 0.99 [95% CI 0.76, 1.31] at 
      18-months. Though these findings were not powered for statistical significance, 
      the trends in HIV outcomes suggest that SYV holds promise for improving 
      antiretroviral therapy (ART) adherence and virologic suppression in YPLWH.
CI  - (c) 2021. The Author(s).
FAU - Dow, Dorothy E
AU  - Dow DE
AUID- ORCID: 0000-0002-9056-1025
AD  - Department of Pediatrics, Infectious Diseases, Duke University Medical Center, 
      Durham, NC, USA. Dorothy.dow@duke.edu.
AD  - Duke Global Health Institute, Box 3499, Durham, NC, 27710, USA. 
      Dorothy.dow@duke.edu.
FAU - O'Donnell, Karen E
AU  - O'Donnell KE
AD  - Center for Health Policy and Inequalities Research, Duke University, Durham, NC, 
      USA.
AD  - Center for Child and Family Health, Durham, NC, USA.
FAU - Mkumba, Laura
AU  - Mkumba L
AD  - Family Health International 360, Durham, NC, USA.
FAU - Gallis, John A
AU  - Gallis JA
AD  - Duke Global Health Institute, Box 3499, Durham, NC, 27710, USA.
AD  - Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
FAU - Turner, Elizabeth L
AU  - Turner EL
AD  - Duke Global Health Institute, Box 3499, Durham, NC, 27710, USA.
AD  - Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
FAU - Boshe, Judith
AU  - Boshe J
AD  - Department of Psychiatry, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
AD  - Kilimanjaro Christian Medical University College, Moshi, Tanzania.
FAU - Shayo, Aisa M
AU  - Shayo AM
AD  - Department of Pediatrics, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
AD  - Kilimanjaro Christian Medical University College, Moshi, Tanzania.
FAU - Cunningham, Coleen K
AU  - Cunningham CK
AD  - Department of Pediatrics, Infectious Diseases, Duke University Medical Center, 
      Durham, NC, USA.
AD  - Duke Global Health Institute, Box 3499, Durham, NC, 27710, USA.
FAU - Mmbaga, Blandina T
AU  - Mmbaga BT
AD  - Duke Global Health Institute, Box 3499, Durham, NC, 27710, USA.
AD  - Department of Pediatrics, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
AD  - Kilimanjaro Christian Medical University College, Moshi, Tanzania.
AD  - Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre, 
      Moshi, Tanzania.
LA  - eng
GR  - P30 AI064518/AI/NIAID NIH HHS/United States
GR  - R25 TW009337/TW/FIC NIH HHS/United States
GR  - K01 TW-009985/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220124
PL  - United States
TA  - AIDS Behav
JT  - AIDS and behavior
JID - 9712133
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adolescent
MH  - Anti-Retroviral Agents/therapeutic use
MH  - Female
MH  - *HIV Infections/drug therapy/epidemiology/psychology
MH  - Humans
MH  - Male
MH  - Mental Health
MH  - Pilot Projects
MH  - Tanzania/epidemiology
MH  - Young Adult
PMC - PMC8784208
OTO - NOTNLM
OT  - Adolescent
OT  - Africa
OT  - HIV
OT  - Mental health
OT  - Tanzania
COIS- All authors report no conflicts of interest.
EDAT- 2022/01/25 06:00
MHDA- 2022/04/30 06:00
PMCR- 2022/01/24
CRDT- 2022/01/24 05:49
PHST- 2021/11/25 00:00 [accepted]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/04/30 06:00 [medline]
PHST- 2022/01/24 05:49 [entrez]
PHST- 2022/01/24 00:00 [pmc-release]
AID - 10.1007/s10461-021-03550-z [pii]
AID - 3550 [pii]
AID - 10.1007/s10461-021-03550-z [doi]
PST - ppublish
SO  - AIDS Behav. 2022 Jun;26(6):2015-2025. doi: 10.1007/s10461-021-03550-z. Epub 2022 
      Jan 24.