PMID- 35068939
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 15
DP  - 2022
TI  - Relationship of the Triglyceride-Glucose Index with Subclinical White Matter 
      Hypersensitivities of Presumed Vascular Origin Among Community-Dwelling Koreans.
PG  - 603-608
LID - 10.2147/IJGM.S346997 [doi]
AB  - PURPOSE: The triglyceride-glucose (TyG) index, a widely accessible measure, has 
      been a surrogate indicator of peripheral insulin resistance, and its clinical 
      importance continues to grow in East Asia. We hypothesized that the TyG index is 
      relevant to subclinical white matter hypersensitivities (WMHs) of presumed 
      vascular origin among community-dwelling Koreans. METHODS: We investigated the 
      relationship between the TyG index and WMHs on brain magnetic resonance imaging 
      scans in 2417 Koreans over 45 years of age without a history of cancer, stroke, 
      or ischemic heart disease. The study population was divided into four groups 
      according to the TyG index quartiles. Using multiple logistic regression 
      analysis, we assessed the odds ratios (ORs) and 95% confidence intervals (95% 
      CIs) for WMHs across the TyG index quartiles. RESULTS: The prevalence of WMHs was 
      significantly higher in the fourth TyG index quartile, with an overall rate of 
      9.3%. After adjusting for potential confounding variables, the ORs of WMHs for 
      the TyG index quartiles were 1.00, 1.47 (95% CI, 0.91-2.40), 1.76 (95% CI, 
      1.05-2.97), and 6.79 (95% CI, 3.85-1.54), respectively. CONCLUSION: We found that 
      higher TyG index values were associated with the brain's WMHs of presumed 
      vascular origin. Our findings suggest that the serum TyG index could be an 
      additional valuable biomarker for assessing the risk of cerebral small vessel 
      disease in the preclinical stage.
CI  - (c) 2022 Jung et al.
FAU - Jung, Dong-Hyuk
AU  - Jung DH
AD  - Department of Family Medicine, Yonsei University College of Medicine, Seoul, 
      03722, Republic of Korea.
FAU - Park, Byoungjin
AU  - Park B
AUID- ORCID: 0000-0003-1733-5301
AD  - Department of Family Medicine, Yonsei University College of Medicine, Seoul, 
      03722, Republic of Korea.
FAU - Lee, Yong-Jae
AU  - Lee YJ
AUID- ORCID: 0000-0002-6697-476X
AD  - Department of Family Medicine, Yonsei University College of Medicine, Seoul, 
      03722, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20220114
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC8766995
OTO - NOTNLM
OT  - cerebral small vessel disease
OT  - endothelial dysfunction
OT  - insulin resistance
OT  - triglyceride-glucose index
OT  - white matter hypersensitivities
COIS- The authors report no conflicts of interest in this work.
EDAT- 2022/01/25 06:00
MHDA- 2022/01/25 06:01
PMCR- 2022/01/14
CRDT- 2022/01/24 08:47
PHST- 2021/11/08 00:00 [received]
PHST- 2022/01/07 00:00 [accepted]
PHST- 2022/01/24 08:47 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/01/25 06:01 [medline]
PHST- 2022/01/14 00:00 [pmc-release]
AID - 346997 [pii]
AID - 10.2147/IJGM.S346997 [doi]
PST - epublish
SO  - Int J Gen Med. 2022 Jan 14;15:603-608. doi: 10.2147/IJGM.S346997. eCollection 
      2022.