PMID- 35069415
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220125
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 12
DP  - 2021
TI  - Serum Inflammatory Factors and Oxidative Stress Factors Are Associated With 
      Increased Risk of Frailty and Cognitive Frailty in Patients With Cerebral Small 
      Vessel Disease.
PG  - 786277
LID - 10.3389/fneur.2021.786277 [doi]
LID - 786277
AB  - Objective: To study the correlation between serum inflammatory factors, oxidative 
      stress factors and frailty, and cognitive frailty in patients with cerebral small 
      vessel disease (CSVD). Methods: A total of 281 patients with CSVD were selected 
      from Tianjin Huanhu Hospital and Inner Mongolia People's Hospital from March 2019 
      to March 2021. CSVD was diagnosed by MRI. The FRAIL scale was used to evaluate 
      the frailty of patients. Patients with CSVD with frailty and MMSE score <27 were 
      considered to have cognitive frailty. Patients with non-cognitive frailty were 
      included in the control group. The Montreal Cognitive Assessment (MoCA) and 
      Mini-Mental State Examination (MMSE) were used to evaluate the cognitive function 
      of patients with CSVD. The serum interleukin 6 (IL-6), tumor necrosis 
      factor-alpha (TNF-alpha), matrix metalloproteinase 3 (MMP-3), superoxide dismutase 
      (SOD), and malondialdehyde (MDA) of patients with CSVD were detected. The 
      correlation between blood inflammatory factors and oxidative stress factors with 
      the frailty and cognitive frailty patients of CSVD were analyzed. Univariate and 
      multivariate logistic regression were used to analyze the correlation between 
      cognitive frailty and CSVD. Results: Among the patients with CSVD selected in 
      this study, female patients and older patients had a higher proportion of frailty 
      (p < 0.001). In the Frail group, MoCA score and MMSE score were significantly 
      lower than in the Pre-Frail and Robust groups, Hamilton Depression Scale (HAMD) 
      and Hamilton Anxiety Scale (HAMA) scores were significantly higher than the 
      Pre-Frail and Robust groups, and the differences were statistically significant 
      (p < 0.05). Serum CRP, IL-6, TNF-alpha, MMP-3, and MDA levels in the Frail group were 
      higher, but SOD levels were lower. The levels of serum CRP, IL-6, TNF-alpha, MMP-3, 
      and MDA in patients with CSVD in the Cognitive Frailty group were significantly 
      higher than those of the Control group, while the levels of SOD were 
      significantly lower than those of the Control group, and the differences were 
      significant (p < 0.001). The results of univariate and multivariate logistic 
      regression analysis showed that CRP, TNF-alpha, MMP-3, and MDA levels were associated 
      with cognitive frailty in patients with CSVD (p < 0.05). Conclusion: The increase 
      of serum CRP, TNF-alpha, MMP-3, and MDA levels are significantly related to the 
      increased risk of frailty and cognitive frailty in patients with CSVD.
CI  - Copyright (c) 2022 Mu, Jiang, Chen, Xiao, Wang, Liu and Wu.
FAU - Mu, Lei
AU  - Mu L
AD  - Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin 
      Medical University, Tianjin, China.
AD  - Department of Geriatrics, Inner Mongolia People's Hospital, Hohhot, China.
FAU - Jiang, Limin
AU  - Jiang L
AD  - Department of Geriatrics, Inner Mongolia People's Hospital, Hohhot, China.
FAU - Chen, Juan
AU  - Chen J
AD  - Department of Geriatrics, Inner Mongolia People's Hospital, Hohhot, China.
FAU - Xiao, Mei
AU  - Xiao M
AD  - Department of Geriatrics, Inner Mongolia People's Hospital, Hohhot, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Neurorehabilitation and Neurology, Tianjin Huanhu Hospital, Tianjin 
      Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin 
      Neurosurgical Institute, Tianjin, China.
FAU - Liu, Peipei
AU  - Liu P
AD  - Department of Neurorehabilitation and Neurology, Tianjin Huanhu Hospital, Tianjin 
      Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin 
      Neurosurgical Institute, Tianjin, China.
FAU - Wu, Jialing
AU  - Wu J
AD  - Department of Neurorehabilitation and Neurology, Tianjin Huanhu Hospital, Tianjin 
      Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin 
      Neurosurgical Institute, Tianjin, China.
LA  - eng
PT  - Journal Article
DEP - 20220106
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC8770428
OTO - NOTNLM
OT  - CRP
OT  - MDA
OT  - MMP-3
OT  - TNF-alpha
OT  - cerebral small vascular disease
OT  - cognitive frailty
OT  - frailty
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/25 06:00
MHDA- 2022/01/25 06:01
PMCR- 2022/01/06
CRDT- 2022/01/24 08:49
PHST- 2021/10/08 00:00 [received]
PHST- 2021/11/25 00:00 [accepted]
PHST- 2022/01/24 08:49 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/01/25 06:01 [medline]
PHST- 2022/01/06 00:00 [pmc-release]
AID - 10.3389/fneur.2021.786277 [doi]
PST - epublish
SO  - Front Neurol. 2022 Jan 6;12:786277. doi: 10.3389/fneur.2021.786277. eCollection 
      2021.