PMID- 35069684
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220125
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 12
DP  - 2021
TI  - Different Associations Between CDKAL1 Variants and Type 2 Diabetes Mellitus 
      Susceptibility: A Meta-analysis.
PG  - 783078
LID - 10.3389/fgene.2021.783078 [doi]
LID - 783078
AB  - Background: CDK5 regulatory subunit associated protein 1 like 1 (CDKAL1) is a 
      major pathogenesis-related protein for type 2 diabetes mellitus (T2DM). Recently, 
      some studies have investigated the association of CDKAL1 susceptibility variants, 
      including rs4712523, rs4712524, and rs9460546 with T2DM. However, the results 
      were inconsistent. This study aimed to evaluate the association of CDKAL1 
      variants and T2DM patients. Methods: A comprehensive meta-analysis was performed 
      to assess the association between CDKAL1 SNPs and T2DM among dominant, recessive, 
      additive, and allele models. Results: We investigated these three CDKAL1 variants 
      to identify T2DM risk. Our findings were as follows: rs4712523 was associated 
      with an increased risk of T2DM for the allele model (G vs A: OR = 1.172; 95% CI: 
      1.103-1.244; p < 0.001) and dominant model (GG + AG vs AA: OR = 1.464; 95% CI: 
      1.073-1.996; p = 0.016); rs4712524 was significantly associated with an increased 
      risk of T2DM for the allele model (G vs A: OR = 1.146; 95% CI: 1.056-1.245; p = 
      0.001), additive model (GG vs AA: OR = 1.455; 95% CI: 1.265-1.673; p < 0.001) 
      recessive model (GG vs AA + AG: OR = 1.343; 95% CI: 1.187-1.518; p < 0.001) and 
      dominant model (GG + AG vs AA: OR = 1.221; 95% CI: 1.155-1.292; p < 0.001); and 
      rs9460546 was associated with an increased risk of T2DM for the allele model (G 
      vs T: OR = 1.215; 95% CI: 1.167-1.264; p = 0.023). The same results were found in 
      the East Asian subgroup for the allele model. Conclusions: Our findings suggest 
      that CDKAL1 polymorphisms (rs4712523, rs4712524, and rs9460546) are significantly 
      associated with T2DM.
CI  - Copyright (c) 2022 Zeng, Zou, Gu, Han, Cao, Wei and Guo.
FAU - Zeng, Qiaoli
AU  - Zeng Q
AD  - Department of Internal Medicine, Shunde Women and Children's Hospital (Maternity 
      and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, 
      Foshan, China.
AD  - Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, 
      Guangdong Medical University, Foshan, China.
AD  - Matenal and Child Research Institute, Shunde Women and Children's Hospital 
      (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical 
      University, Foshan, China.
FAU - Zou, Dehua
AU  - Zou D
AD  - Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, 
      Guangdong Medical University, Foshan, China.
AD  - Matenal and Child Research Institute, Shunde Women and Children's Hospital 
      (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical 
      University, Foshan, China.
AD  - State Key Laboratory for Quality Research of Chinese Medicines, Macau University 
      of Science and Technology, Taipa, Macau SAR, China.
FAU - Gu, Shanshan
AU  - Gu S
AD  - Matenal and Child Research Institute, Shunde Women and Children's Hospital 
      (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical 
      University, Foshan, China.
AD  - Institute of Neurology, Affiliated Hospital of Guangdong Medical University, 
      Zhanjiang, China.
FAU - Han, Fengqiong
AU  - Han F
AD  - Department of Obstetric, Shunde Women and Children's Hospital (Maternity and 
      Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, 
      Foshan, China.
FAU - Cao, Shilin
AU  - Cao S
AD  - Department of Medical, Shunde Women and Children's Hospital (Maternity and Child 
      Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, 
      China.
FAU - Wei, Yue
AU  - Wei Y
AD  - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and 
      Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, 
      Foshan, China.
FAU - Guo, Runmin
AU  - Guo R
AD  - Department of Internal Medicine, Shunde Women and Children's Hospital (Maternity 
      and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, 
      Foshan, China.
AD  - Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, 
      Guangdong Medical University, Foshan, China.
AD  - Matenal and Child Research Institute, Shunde Women and Children's Hospital 
      (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical 
      University, Foshan, China.
AD  - Department of Endocrinology, Affiliated Hospital of Guangdong Medical University, 
      Zhanjiang, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220105
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC8766415
OTO - NOTNLM
OT  - CDKAL1
OT  - meta-analysis
OT  - polymorphisms
OT  - susceptibility
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/25 06:00
MHDA- 2022/01/25 06:01
PMCR- 2022/01/05
CRDT- 2022/01/24 08:49
PHST- 2021/09/25 00:00 [received]
PHST- 2021/12/13 00:00 [accepted]
PHST- 2022/01/24 08:49 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/01/25 06:01 [medline]
PHST- 2022/01/05 00:00 [pmc-release]
AID - 783078 [pii]
AID - 10.3389/fgene.2021.783078 [doi]
PST - epublish
SO  - Front Genet. 2022 Jan 5;12:783078. doi: 10.3389/fgene.2021.783078. eCollection 
      2021.