PMID- 35070279
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 2049-0801 (Print)
IS  - 2049-0801 (Electronic)
IS  - 2049-0801 (Linking)
VI  - 73
DP  - 2022 Jan
TI  - Relationship of serum copper and HLADR4 tissue typing to disease activity and 
      severity in patients with rheumatoid arthritis: A cross sectional study.
PG  - 103193
LID - 10.1016/j.amsu.2021.103193 [doi]
LID - 103193
AB  - BACKGROUND: Rheumatoid arthritis is a chronic disabling disease associated with 
      high burden on individuals and national health system. Early detection of 
      rheumatoid arthritis is helpful in management and preventing further 
      complications. OBJECTIVE: To assess the relationship between each of serum copper 
      and human leukocyte antigen (HLA)-DR tissue typing with the activity and severity 
      of rheumatoid arthritis. METHODS: This study was an observational prospective 
      cross sectional study implemented in the Rzgary general teaching hospital in 
      Erbil governorate-Iraq from November 1, 2019, to October 31, 2020. Study sample 
      included fifty rheumatoid arthritis patients. The diagnosis of rheumatoid 
      arthritis was done according to 2010-American College of Rheumatology-European 
      League against Rheumatism criteria. The serum copper and HLA-DR4 typing were 
      assessed in regard to activity and severity of rheumatoid arthritis patients. 
      RESULTS: This study found that high serum copper level was directly related to 
      both active and severe rheumatoid arthritis disease (p < 0.001). Additionally, 
      this study revealed that positive HLADR4 typing was related to severe rheumatoid 
      arthritis disease (p < 0.001). This study revealed no significant relationship 
      between rheumatoid arthritis activity and severity with HLADR4 subtypes. 
      CONCLUSIONS: The serum copper level and HLA-DR typing of patients with rheumatoid 
      arthritis may be useful in prediction of rheumatoid arthritis disease activity 
      and severity.
CI  - (c) 2021 The Authors.
FAU - Aldabbagh, Khalid Ahmad Omer
AU  - Aldabbagh KAO
AD  - Department of Medicine, College of Medicine, Hawler Medical University, Erbil, 
      Iraq.
FAU - Al-Bustany, Dashty Abbas
AU  - Al-Bustany DA
AD  - Department of Medicine, College of Medicine, Hawler Medical University, Erbil, 
      Iraq.
LA  - eng
PT  - Journal Article
DEP - 20211224
PL  - England
TA  - Ann Med Surg (Lond)
JT  - Annals of medicine and surgery (2012)
JID - 101616869
PMC - PMC8767240
OTO - NOTNLM
OT  - Activity
OT  - Copper
OT  - HLA-DR typing
OT  - Rheumatoid arthritis
OT  - Severity
COIS- None.
EDAT- 2022/01/25 06:00
MHDA- 2022/01/25 06:01
PMCR- 2021/12/24
CRDT- 2022/01/24 08:51
PHST- 2021/09/28 00:00 [received]
PHST- 2021/12/12 00:00 [revised]
PHST- 2021/12/19 00:00 [accepted]
PHST- 2022/01/24 08:51 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/01/25 06:01 [medline]
PHST- 2021/12/24 00:00 [pmc-release]
AID - S2049-0801(21)01143-2 [pii]
AID - 103193 [pii]
AID - 10.1016/j.amsu.2021.103193 [doi]
PST - epublish
SO  - Ann Med Surg (Lond). 2021 Dec 24;73:103193. doi: 10.1016/j.amsu.2021.103193. 
      eCollection 2022 Jan.