PMID- 35070783
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240405
IS  - 2220-3206 (Print)
IS  - 2220-3206 (Electronic)
IS  - 2220-3206 (Linking)
VI  - 11
IP  - 12
DP  - 2021 Dec 19
TI  - Autism spectrum disorder and personality disorders: Comorbidity and differential 
      diagnosis.
PG  - 1366-1386
LID - 10.5498/wjp.v11.i12.1366 [doi]
AB  - BACKGROUND: Differential diagnosis, comorbidities and overlaps with other 
      psychiatric disorders are common among adults with autism spectrum disorder 
      (ASD), but clinical assessments often omit screening for personality disorders 
      (PD), which are especially common in individuals with high-functioning ASD where 
      there is less need for support. AIM: To summarize the research findings on PD in 
      adults with ASD and without intellectual disability, focusing on comorbidity and 
      differential diagnosis. METHODS: PubMed searches were performed using the key 
      words "Asperger's Syndrome", "Autism", "Personality", "Personality disorder" and 
      "comorbidity" in order to identify relevant articles published in English. Grey 
      literature was identified through searching Google Scholar. The literature 
      reviews and reference sections of selected papers were also examined for 
      additional potential studies. The search was restricted to studies published up 
      to April 2020. This review is based on the Preferred Reporting Items for 
      Systematic Reviews and Meta-Analyses method. RESULTS: The search found 22 studies 
      carried out on ASD adults without intellectual disability that met the inclusion 
      criteria: 16 evaluated personality profiles or PD in ASD (comorbidity), five 
      compared ASD and PD (differential diagnosis) and one performed both tasks. There 
      were significant differences in the methodological approaches, including the ASD 
      diagnostic instruments and personality measures. Cluster A and cluster C PD are 
      the most frequent co-occurring PD, but overlapping features should be considered. 
      Data on differential diagnosis were only found with cluster A and cluster B PD. 
      CONCLUSION: ASD in high-functioning adults is associated with a distinct 
      personality profile even if variability exists. Further studies are needed to 
      explore the complex relationship between ASD and PD.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Rinaldi, Camilla
AU  - Rinaldi C
AD  - Adult Autism Center, Department of Mental Health, ASL Citta di Torino, Turin 
      10138, Italy.
FAU - Attanasio, Margherita
AU  - Attanasio M
AD  - Department of Applied Clinical Sciences and Biotechnology, University of 
      L'Aquila, L'Aquila 67100, Italy.
FAU - Valenti, Marco
AU  - Valenti M
AD  - Department of Applied Clinical Sciences and Biotechnology, University of 
      L'Aquila, L'Aquila 67100, Italy.
FAU - Mazza, Monica
AU  - Mazza M
AD  - Department of Applied Clinical Sciences and Biotechnology, University of 
      L'Aquila, L'Aquila 67100, Italy.
FAU - Keller, Roberto
AU  - Keller R
AD  - Adult Autism Center, Department of Mental Health, ASL Citta di Torino, Turin 
      10138, Italy. rokel2003@libero.it.
LA  - eng
PT  - Journal Article
DEP - 20211219
PL  - United States
TA  - World J Psychiatry
JT  - World journal of psychiatry
JID - 101610480
PMC - PMC8717043
OTO - NOTNLM
OT  - Adulthood
OT  - Asperger's Syndrome
OT  - Autism spectrum disorder
OT  - Comorbidity
OT  - Differential diagnosis
OT  - Personality disorder
COIS- Conflict-of-interest statement: The authors declare no conflict of interests for 
      this article.
EDAT- 2022/01/25 06:00
MHDA- 2022/01/25 06:01
PMCR- 2021/12/19
CRDT- 2022/01/24 08:53
PHST- 2021/02/17 00:00 [received]
PHST- 2021/05/26 00:00 [revised]
PHST- 2021/11/24 00:00 [accepted]
PHST- 2022/01/24 08:53 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/01/25 06:01 [medline]
PHST- 2021/12/19 00:00 [pmc-release]
AID - 10.5498/wjp.v11.i12.1366 [doi]
PST - epublish
SO  - World J Psychiatry. 2021 Dec 19;11(12):1366-1386. doi: 10.5498/wjp.v11.i12.1366. 
      eCollection 2021 Dec 19.