PMID- 35070935
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230102
IS  - 1976-8257 (Print)
IS  - 2234-2753 (Electronic)
IS  - 1976-8257 (Linking)
VI  - 38
IP  - 1
DP  - 2022 Jan
TI  - Estrogen exposure causes the progressive growth of SK-Hep1-derived tumor in 
      ovariectomized mice.
PG  - 1-7
LID - 10.1007/s43188-021-00100-6 [doi]
AB  - Liver cancer, one of the leading death causes, has different incidence and 
      mortality rates in men and women. The influencing factor is considered to 
      estrogen. However, the role of estrogen in liver cancer remains controversial. In 
      this study, we investigated the effects of estrogen on tumor progression. Total 
      RNA sequencing was analyzed in SK-Hep1-derived tumor tissues, and 15 genes were 
      expressed only in female mice. Among the differentially expressed genes, matrix 
      metalloprotease 7 (MMP7), germ cell associated 1 (GSG1), and chromosome 6 open 
      reading frame 15 (C6orf15) were associated with significantly different overall 
      survival rates based on their expression level in liver cancer patients. 
      Interestingly, exogenous estrogen aggravated SK-Hep1-derived tumor growth in 
      ovariectomized (OVX) mice. When OVX mice were treated with exogenous estrogen, 
      SK-Hep1-derived tumor tissues exhibited high MMP7 expression levels and low GSG1 
      and C6orf15 expression levels. These expression patterns were consistent with 
      those of liver cancer patients with low overall survival rates. These results 
      suggest that these genes are expected to be prognostic biomarkers of liver 
      cancer. In conclusion, our results suggest that continuous estrogen exposure may 
      promote tumor growth in OVX mice.
CI  - (c) Korean Society of Toxicology 2021.
FAU - Oh, Sungryong
AU  - Oh S
AD  - College of Pharmacy, Duksung Women's University, 33, Samyang-ro 144-gil, 
      Dobong-gu, Seoul, 01369 South Korea. GRID: grid.410884.1. ISNI: 0000 0004 0532 
      6173
AD  - Duksung Innovative Drug Center, Duksung Women's University, 33, Samyang-ro 
      144-gil, Dobong-gu, Seoul, 01369 South Korea. GRID: grid.410884.1. ISNI: 0000 
      0004 0532 6173
FAU - Kwon, Hee Jung
AU  - Kwon HJ
AD  - College of Pharmacy, Duksung Women's University, 33, Samyang-ro 144-gil, 
      Dobong-gu, Seoul, 01369 South Korea. GRID: grid.410884.1. ISNI: 0000 0004 0532 
      6173
AD  - Duksung Innovative Drug Center, Duksung Women's University, 33, Samyang-ro 
      144-gil, Dobong-gu, Seoul, 01369 South Korea. GRID: grid.410884.1. ISNI: 0000 
      0004 0532 6173
FAU - Jung, Joohee
AU  - Jung J
AUID- ORCID: 0000-0001-9124-9052
AD  - College of Pharmacy, Duksung Women's University, 33, Samyang-ro 144-gil, 
      Dobong-gu, Seoul, 01369 South Korea. GRID: grid.410884.1. ISNI: 0000 0004 0532 
      6173
AD  - Duksung Innovative Drug Center, Duksung Women's University, 33, Samyang-ro 
      144-gil, Dobong-gu, Seoul, 01369 South Korea. GRID: grid.410884.1. ISNI: 0000 
      0004 0532 6173
LA  - eng
PT  - Journal Article
DEP - 20210527
PL  - Singapore
TA  - Toxicol Res
JT  - Toxicological research
JID - 101483324
PMC - PMC8748573
OTO - NOTNLM
OT  - Estrogen
OT  - Ovariectomized mice
OT  - SK-Hep1 cells
OT  - Tumor growth
COIS- Conflict of interestThe authors have no conflict of interest to disclose.
EDAT- 2022/01/25 06:00
MHDA- 2022/01/25 06:01
PMCR- 2023/01/01
CRDT- 2022/01/24 08:54
PHST- 2021/03/31 00:00 [received]
PHST- 2021/04/29 00:00 [revised]
PHST- 2021/05/15 00:00 [accepted]
PHST- 2022/01/24 08:54 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/01/25 06:01 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 100 [pii]
AID - 10.1007/s43188-021-00100-6 [doi]
PST - epublish
SO  - Toxicol Res. 2021 May 27;38(1):1-7. doi: 10.1007/s43188-021-00100-6. eCollection 
      2022 Jan.