PMID- 35071276
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220125
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - Vitreomacular Interface Abnormalities in Myopic Foveoschisis: Correlation With 
      Morphological Features and Outcome of Vitrectomy.
PG  - 796127
LID - 10.3389/fmed.2021.796127 [doi]
LID - 796127
AB  - Purpose: To compare the morphologic characteristics and response to surgery of 
      myopic foveoschisis (MF) with different patterns of vitreomacular interface 
      abnormalities (VMIAs). Methods: In this observational case series, 158 eyes of 
      121 MF patients with epiretinal membrane (ERM) or vitreomacular traction (VMT) 
      based on optical coherence tomography (OCT) were enrolled. All the eyes were 
      divided into two groups by the pattern of VMIAs: ERM and VMT group. Sixty-one 
      eyes underwent pars plana vitrectomy (PPV) and were followed up for at least 6 
      months. The morphologic characteristics based on OCT and the surgical outcome 
      were evaluated. Outcome: ERM and VMT were found in 47.47 and 52.53% of the cases, 
      respectively. A higher rate of foveal detachment (61.4 vs. 26.7%; p < 0.001) and 
      a higher rate of outer lamellar macular hole (45.8 vs. 21.3%; p = 0.001) were 
      detected in the eyes with VMT compared with those with ERM. In contrast, a lower 
      rate of inner lamellar macular hole (28.9 vs. 60.0%; p = 0.001) was detected in 
      the eyes with VMT compared with those with ERM. The disruption of the external 
      limiting membrane (ELM) was more common in the eyes with VMT than in those with 
      ERM (45.8 vs. 21.3%; p = 0.001). PPV was performed in 61 eyes with a mean 
      follow-up time of 23.55 +/- 19.92 months. After surgery, anatomical resolution was 
      achieved in 51 eyes (83.6%). At the final visit, the mean central foveal 
      thickness (CFT) decreased significantly from 547.83 to 118.74 mum, and the mean 
      LogMAR BCVA improved significantly from 0.92 to 0.57. The VMT group was 
      associated with a higher proportion of eyes with visual acuity improvement 
      postoperatively (p = 0.02) and had more a decrease of CFT (P = 0.007) compared 
      with the ERM group. Conclusion: In the eyes with MF, outer retinal lesions 
      occurred more frequently in the eyes with VMT, whereas inner retinal lesions 
      occurred more frequently in the eyes with ERM. Tangential force generated by ERM 
      may act as a causative factor for the inner retinal lesions in MF, and 
      inward-directed force resulting from VMT may act as a causative factor for outer 
      retinal lesions in MF.
CI  - Copyright (c) 2022 Fang, Wang, Chen, Liang, Li, Mao, Xie and Zhang.
FAU - Fang, Dong
AU  - Fang D
AD  - Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Jinan 
      University, Shenzhen, China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Ophthalmology, Chengdu Second People's Hospital, Chengdu, China.
FAU - Chen, Lu
AU  - Chen L
AD  - Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Jinan 
      University, Shenzhen, China.
FAU - Liang, Jia
AU  - Liang J
AD  - Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Jinan 
      University, Shenzhen, China.
FAU - Li, Kunke
AU  - Li K
AD  - Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Jinan 
      University, Shenzhen, China.
FAU - Mao, Xingxing
AU  - Mao X
AD  - Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Jinan 
      University, Shenzhen, China.
FAU - Xie, Ting
AU  - Xie T
AD  - Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Jinan 
      University, Shenzhen, China.
FAU - Zhang, Shaochong
AU  - Zhang S
AD  - Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Jinan 
      University, Shenzhen, China.
LA  - eng
PT  - Journal Article
DEP - 20220105
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8766811
OTO - NOTNLM
OT  - morphological feature
OT  - myopic foveoschisis
OT  - optical coherence tomography
OT  - pars plana vitrectomy
OT  - vitreomacular interface abnormalities
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/25 06:00
MHDA- 2022/01/25 06:01
PMCR- 2022/01/05
CRDT- 2022/01/24 08:55
PHST- 2021/10/15 00:00 [received]
PHST- 2021/11/22 00:00 [accepted]
PHST- 2022/01/24 08:55 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/01/25 06:01 [medline]
PHST- 2022/01/05 00:00 [pmc-release]
AID - 10.3389/fmed.2021.796127 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Jan 5;8:796127. doi: 10.3389/fmed.2021.796127. 
      eCollection 2021.