PMID- 35071347
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220125
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Electrocardiography Score for Left Ventricular Systolic Dysfunction in Non-ST 
      Segment Elevation Acute Coronary Syndrome.
PG  - 764575
LID - 10.3389/fcvm.2021.764575 [doi]
LID - 764575
AB  - Background: Few studies have characterized electrocardiography (ECG) patterns 
      correlated with left ventricular (LV) systolic dysfunction in patients with 
      non-ST segment elevation acute coronary syndrome (NSTE-ACS). Objectives: This 
      study aims to develop ECG pattern-derived scores to predict LV systolic 
      dysfunction in NSTE-ACS patients. Methods: A total of 466 patients with NSTE-ACS 
      were retrospectively enrolled. LV ejection fraction (LVEF) was assessed by 
      echocardiography within 72 h after the first triage ECG acquisition; there was no 
      coronary intervention in between. ECG score was developed to predict LVEF < 40%. 
      Performance of LVEF, the Global Registry of Acute Coronary Events (GRACE), 
      Thrombolysis in Myocardial Infarction (TIMI) and ECG scores to predict 24-month 
      all-cause mortality were analyzed. Subgroups with varying LVEF, GRACE and TIMI 
      scores were stratified by ECG score to identify patients at high risk of 
      mortality. Results: LVEF < 40% was present in 20% of patients. We developed the 
      PQRST score by multivariate logistic regression, including poor R wave 
      progression, QRS duration > 110 ms, heart rate > 100 beats per min, and 
      ST-segment depression >/= 1 mm in >/= 2 contiguous leads, ranging from 0 to 6.5. The 
      score had an area under the curve (AUC) of 0.824 in the derivation cohort and 
      0.899 in the validation cohort for discriminating LVEF < 40%. A PQRST score >/= 3 
      could stratify high-risk patients with LVEF >/= 40%, GRACE score > 140, or TIMI 
      score >/= 3 regarding 24-month all-cause mortality. Conclusions: The PQRST score 
      could predict LVEF < 40% in NSTE-ACS patients and identify patients at high risk 
      of mortality in the subgroups of patients with LVEF >/= 40%, GRACE score > 140 or 
      TIMI score >/= 3.
CI  - Copyright (c) 2022 Lin, Hsiung, Yin, Tsao, Lai and Huang.
FAU - Lin, Wei-Chen
AU  - Lin WC
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
AD  - Department of Internal Medicine, Keelung Hospital, Ministry of Health and 
      Welfare, Keelung, Taiwan.
FAU - Hsiung, Ming-Chon
AU  - Hsiung MC
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
FAU - Yin, Wei-Hsian
AU  - Yin WH
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
AD  - Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
FAU - Tsao, Tien-Ping
AU  - Tsao TP
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
AD  - Division of Cardiology, Department of Internal Medicine, National Defense Medical 
      Center, Tri-Service General Hospital, Taipei, Taiwan.
FAU - Lai, Wei-Tsung
AU  - Lai WT
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
FAU - Huang, Kuan-Chih
AU  - Huang KC
AD  - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
AD  - Section of Cardiology, Department of Internal Medicine, National Taiwan 
      University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20220107
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8777009
OTO - NOTNLM
OT  - GRACE
OT  - NSTE-ACS
OT  - TIMI
OT  - cardiac point of care ultrasounds
OT  - electrocardiography
OT  - left ventricular systolic dysfunction
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/25 06:00
MHDA- 2022/01/25 06:01
PMCR- 2021/01/01
CRDT- 2022/01/24 08:55
PHST- 2021/08/25 00:00 [received]
PHST- 2021/12/07 00:00 [accepted]
PHST- 2022/01/24 08:55 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/01/25 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.764575 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Jan 7;8:764575. doi: 10.3389/fcvm.2021.764575. 
      eCollection 2021.