PMID- 35071517
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220125
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 10
IP  - 1
DP  - 2022 Jan 7
TI  - Alterations in blink and masseter reflex latencies in older adults with 
      neurocognitive disorder and/or diabetes mellitus.
PG  - 177-188
LID - 10.12998/wjcc.v10.i1.177 [doi]
AB  - BACKGROUND: Blink and masseter reflexes provide reliable, quantifiable data on 
      the function of the central nervous system: Delayed latencies have been found in 
      patients with neurocognitive disorder (ND) and type 2 diabetes mellitus (T2DM), 
      but this has not been studied in patients with both pathologies. AIM: To 
      investigate if older adults with ND plus T2DM have prolonged latencies of blink 
      and masseter-reflex and if they were associated with disease progression. 
      METHODS: This cross-sectional study included 227 older adults (> 60 years) from 
      Colima, Mexico. Neurocognitive disorder was identified by a neuropsychological 
      battery test, and T2DM identified by medical history, fasting glucose, and 
      glycosylated hemoglobin. Latencies in the early reflex (R1), ipsilateral late 
      (R2), and contralateral late (R2c) components of the blink reflex were analyzed 
      for all subjects, and 183 subjects were analyzed for latency of the masseter 
      reflex. RESULTS: In 20.7% of participants, ND was detected. In 37%, T2DM was 
      detected. Latencies in R1, R2, and R2c were significantly prolonged for groups 
      with ND plus T2DM, ND, and T2DM, compared with the control group (P < 0.0001). 
      The masseter reflex was only prolonged in older adults (regardless of T2DM 
      status) with ND vs controls (P = 0.030). In older adults with ND and without 
      T2DM, the more the cognitive impairment progressed, the more prolonged latencies 
      in R2 and R2c presented (P < 0.01). CONCLUSION: These findings suggest that blink 
      and masseter reflexes could be used to evaluate possible changes in brainstem 
      circuits in older adults with ND and T2DM.
CI  - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Bricio-Barrios, Jaime Alberto
AU  - Bricio-Barrios JA
AD  - Faculty of Medicine, University of Colima, Colima 28040, Colima, Mexico.
FAU - Rios-Bracamontes, Eder
AU  - Rios-Bracamontes E
AD  - General Hospital Zone #1, Mexican Social Security Institute, Villa de Alvarez 
      28983, Colima, Mexico.
FAU - Rios-Silva, Monica
AU  - Rios-Silva M
AD  - University Biomedical Research Center, University of Colima, Colima 28045, 
      Colima, Mexico.
FAU - Huerta, Miguel
AU  - Huerta M
AD  - University Biomedical Research Center, University of Colima, Colima 28045, 
      Colima, Mexico.
FAU - Serrano-Moreno, Walter
AU  - Serrano-Moreno W
AD  - University Biomedical Research Center, University of Colima, Colima 28045, 
      Colima, Mexico.
FAU - Barrios-Navarro, Jose Enrique
AU  - Barrios-Navarro JE
AD  - Faculty of Medicine, University of Colima, Colima 28040, Colima, Mexico.
FAU - Ortiz, Genaro Gabriel
AU  - Ortiz GG
AD  - Department of Philosophical and Methodological Disciplines, University Health 
      Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
FAU - Huerta-Trujillo, Miguel
AU  - Huerta-Trujillo M
AD  - Faculty of Medicine, University of Colima, Colima 28040, Colima, Mexico.
FAU - Guzman-Esquivel, Jose
AU  - Guzman-Esquivel J
AD  - General Hospital Zone #1, Mexican Social Security Institute, Villa de Alvarez 
      28983, Colima, Mexico.
FAU - Trujillo, Xochitl
AU  - Trujillo X
AD  - University Biomedical Research Center, University of Colima, Colima 28045, 
      Colima, Mexico. rosio@ucol.mx.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC8727253
OTO - NOTNLM
OT  - Blink reflex
OT  - Brainstem reflexes
OT  - Masseter reflex
OT  - Neurocognitive disorder
OT  - Older adults
OT  - Type 2 diabetes mellitus
COIS- Conflict-of-interest statement: The authors report no potential conflicts of 
      interest relevant to this article.
EDAT- 2022/01/25 06:00
MHDA- 2022/01/25 06:01
PMCR- 2022/01/07
CRDT- 2022/01/24 08:55
PHST- 2021/03/12 00:00 [received]
PHST- 2021/07/30 00:00 [revised]
PHST- 2021/11/25 00:00 [accepted]
PHST- 2022/01/24 08:55 [entrez]
PHST- 2022/01/25 06:00 [pubmed]
PHST- 2022/01/25 06:01 [medline]
PHST- 2022/01/07 00:00 [pmc-release]
AID - 10.12998/wjcc.v10.i1.177 [doi]
PST - ppublish
SO  - World J Clin Cases. 2022 Jan 7;10(1):177-188. doi: 10.12998/wjcc.v10.i1.177.