PMID- 35074564
OWN - NLM
STAT- MEDLINE
DCOM- 20220309
LR  - 20220531
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 211
DP  - 2022 Mar 20
TI  - Optimization of sensing-pad functionalizing strategy toward separative 
      extended-gate FET biosensors for PSA detection.
PG  - 114597
LID - S0731-7085(22)00018-8 [pii]
LID - 10.1016/j.jpba.2022.114597 [doi]
AB  - In this study, separative extended-gate AlGaAs/GaAs high electron mobility 
      transistor (HEMT) biosensor is proposed for prostate-specific antigen (PSA) 
      detection. Zinc oxide nanotetrapods (T-ZnO) with a four-leg structure is 
      introduced onto the sensing pad to form a three-dimensional (3D) and concave 
      detection front. Compared with common plane front, the elaborately-designed-3D 
      and concave detection front can offer more biological modification sites and 
      decrease the Debye volume, resultantly improving both the detection scope and 
      sensitivity. Anti-PSA probes can be fixed at any sites of T-ZnO via a chemical 
      bio-functionalization method, which facilitates better detection performance by 
      comparison with a physical modification scheme. On the other hand, the T-ZnO 
      nanostructures with the four-leg configuration are capable of releasing the 
      stress and erosion effect of the solution on the plane Au film, contributing to a 
      great improvement in the reliability of the biosensors. The optimized biosensors 
      with chemical bio-functionalized T-ZnO detection front demonstrate good linear 
      current/voltage response to label-free PSA target in the concentration range from 
      5 fg/ml~5 ng/ml and a sensitivity variation ~ 1.3% dec(-1).
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Yu, Jiahuan
AU  - Yu J
AD  - Laboratory of Advanced Nano Materials and Devices, Ningbo Institute of Materials 
      Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People's 
      Republic of China; Center of Materials Science and Optoelectronics Engineering, 
      University of Chinese Academy of Sciences, Beijing 100049, People's Republic of 
      China.
FAU - Gao, Guosheng
AU  - Gao G
AD  - HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, 
      People's Republic of China.
FAU - Sun, Bo
AU  - Sun B
AD  - Laboratory of Advanced Nano Materials and Devices, Ningbo Institute of Materials 
      Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People's 
      Republic of China.
FAU - Liang, Lingyan
AU  - Liang L
AD  - Laboratory of Advanced Nano Materials and Devices, Ningbo Institute of Materials 
      Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People's 
      Republic of China. Electronic address: lly@nimte.ac.cn.
FAU - Shen, Qiang
AU  - Shen Q
AD  - HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, 
      People's Republic of China.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - Key Laboratory of Semiconductor Material Sciences, Beijing Key Laboratory of Low 
      Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, 
      Chinese Academy of Sciences, Beijing 100083, People's Republic of China. 
      Electronic address: zhang_yang@semi.ac.cn.
FAU - Cao, Hongtao
AU  - Cao H
AD  - Laboratory of Advanced Nano Materials and Devices, Ningbo Institute of Materials 
      Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People's 
      Republic of China; Center of Materials Science and Optoelectronics Engineering, 
      University of Chinese Academy of Sciences, Beijing 100049, People's Republic of 
      China. Electronic address: h_cao@nimte.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20220115
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
RN  - SOI2LOH54Z (Zinc Oxide)
SB  - IM
MH  - *Biosensing Techniques/methods
MH  - Humans
MH  - Male
MH  - *Prostate-Specific Antigen/analysis
MH  - Reproducibility of Results
MH  - Zinc Oxide/chemistry
OTO - NOTNLM
OT  - Debye volume
OT  - Ion-sensitive field effect transistors
OT  - Plug-in-card-type
OT  - Portable biosensors
OT  - Prostate cancer
EDAT- 2022/01/26 06:00
MHDA- 2022/03/11 06:00
CRDT- 2022/01/25 05:41
PHST- 2021/07/18 00:00 [received]
PHST- 2022/01/06 00:00 [revised]
PHST- 2022/01/13 00:00 [accepted]
PHST- 2022/01/26 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2022/01/25 05:41 [entrez]
AID - S0731-7085(22)00018-8 [pii]
AID - 10.1016/j.jpba.2022.114597 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2022 Mar 20;211:114597. doi: 10.1016/j.jpba.2022.114597. 
      Epub 2022 Jan 15.