PMID- 35074702 OWN - NLM STAT- MEDLINE DCOM- 20220328 LR - 20220401 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 240 DP - 2022 Feb TI - Cerebello-limbic functional connectivity patterns in youth at clinical high risk for psychosis. PG - 220-227 LID - S0920-9964(21)00525-9 [pii] LID - 10.1016/j.schres.2021.12.041 [doi] AB - Youth at clinical high risk (CHR) for psychosis can present not only with characteristic attenuated psychotic symptoms but also may have other comorbid conditions, including anxiety and depression. These undifferentiated mood symptoms can overlap with the clinical presentation of youth with Distress syndromes. Increased resting-state functional connectivity within cerebello-thalamo-cortical (CTC) pathways has been proposed as a trait-specific biomarker for CHR. However, it is unclear whether this functional neural signature remains specific when compared to a different risk group: youth with Distress syndromes. The purpose of the present work was to describe CTC alterations that distinguish between CHR and Distressed individuals. Using machine learning algorithms, we analyzed CTC connectivity features of CHR (n = 51), Distressed (n = 41), and healthy control (n = 36) participants. We found four cerebellar (lobes VII and left Crus II anterior/posterior) and two basal ganglia (right putamen and right thalamus) nodes containing a set of specific connectivity features that distinguished between CHR, Distressed and healthy control groups. Hyperconnectivity between medial lobule VIIb, somatomotor network and middle temporal gyrus was associated with CHR status and more severe symptoms. Detailed atlas parcellation suggested that CHR individuals may have dysfunction mainly within the associative (cognitive) pathways, particularly, between those brain areas responsible for the multi-sensory signal integration. CI - Copyright (c) 2022 Elsevier B.V. All rights reserved. FAU - Nogovitsyn, Nikita AU - Nogovitsyn N AD - Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. Electronic address: n.nogovitsyn@ucalgary.ca. FAU - Metzak, Paul D AU - Metzak PD AD - Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Casseb, Raphael F AU - Casseb RF AD - Seaman Family MR Research Centre, Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Souza, Roberto AU - Souza R AD - Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. FAU - Harris, Jacqueline K AU - Harris JK AD - Department of Computer Science, University of Alberta, Edmonton, AB, Canada. FAU - Prati, Lionel M AU - Prati LM AD - Rotman Research Institute, Baycrest and Department of Medical Biophysics, University of Toronto, ON, Canada. FAU - Zamyadi, Mojdeh AU - Zamyadi M AD - Rotman Research Institute, Baycrest and Department of Medical Biophysics, University of Toronto, ON, Canada. FAU - Bray, Signe L AU - Bray SL AD - Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Child and Adolescent Imaging Research (CAIR) Program at Alberta Children's Hospital Research Institute, Calgary, AB, Canada. FAU - Lebel, Catherine AU - Lebel C AD - Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Child and Adolescent Imaging Research (CAIR) Program at Alberta Children's Hospital Research Institute, Calgary, AB, Canada. FAU - Hassel, Stefanie AU - Hassel S AD - Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Strother, Stephen AU - Strother S AD - Rotman Research Institute, Baycrest, Toronto, ON, Canada. FAU - Goldstein, Benjamin I AU - Goldstein BI AD - Centre for Youth Bipolar Disorder, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Psychiatry and Pharmacology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Wang, JianLi AU - Wang J AD - Work & Mental health Research Unit, Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. FAU - Kennedy, Sidney H AU - Kennedy SH AD - Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. FAU - MacQueen, Glenda M AU - MacQueen GM AD - Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Addington, Jean AU - Addington J AD - Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220121 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adolescent MH - Brain MH - Brain Mapping MH - Humans MH - Magnetic Resonance Imaging MH - Neural Pathways/diagnostic imaging MH - *Psychotic Disorders/diagnostic imaging MH - *Schizophrenia OTO - NOTNLM OT - Associative loops OT - CHR OT - Functional connectivity OT - Resting state EDAT- 2022/01/26 06:00 MHDA- 2022/03/29 06:00 CRDT- 2022/01/25 05:45 PHST- 2020/07/16 00:00 [received] PHST- 2021/10/28 00:00 [revised] PHST- 2021/12/24 00:00 [accepted] PHST- 2022/01/26 06:00 [pubmed] PHST- 2022/03/29 06:00 [medline] PHST- 2022/01/25 05:45 [entrez] AID - S0920-9964(21)00525-9 [pii] AID - 10.1016/j.schres.2021.12.041 [doi] PST - ppublish SO - Schizophr Res. 2022 Feb;240:220-227. doi: 10.1016/j.schres.2021.12.041. Epub 2022 Jan 21.