PMID- 35074793
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20240502
IS  - 2157-1422 (Electronic)
IS  - 2157-1422 (Linking)
VI  - 12
IP  - 5
DP  - 2022 May 27
TI  - Endothelial Connexins in Developmental and Pathological Angiogenesis.
LID - 10.1101/cshperspect.a041158 [doi]
LID - a041158
AB  - Connexins (Cxs) constitute a large family of transmembrane proteins that form gap 
      junction channels, which enable the direct transfer of small signaling molecules 
      from cell to cell. In blood vessels, Cx channels allow the endothelial cells 
      (ECs) to respond to external and internal cues as a whole and, thus, contribute 
      to the maintenance of vascular homeostasis. While the role of Cxs has been 
      extensively studied in large arteries, a growing body of evidence suggests that 
      they also play a role in the formation of microvascular networks. Since the 
      formation of new blood vessels requires the coordinated response of ECs to 
      external stimuli, endothelial Cxs may play an important role there. Recent 
      studies in developmental and pathologic models reveal that EC Cxs regulate 
      physiological and pathological angiogenesis through canonical and noncanonical 
      functions, making these proteins potential therapeutic targets for the 
      development of new strategies aimed at a better control of angiogenesis.
CI  - Copyright (c) 2022 Cold Spring Harbor Laboratory Press; all rights reserved.
FAU - Haefliger, Jacques-Antoine
AU  - Haefliger JA
AD  - Department of Medicine, Lausanne University Hospital, 1005 Lausanne, Switzerland.
FAU - Meda, Paolo
AU  - Meda P
AD  - Department of Cell Physiology and Metabolism, University of Geneva, Medical 
      Center, 1211 Geneva, Switzerland.
FAU - Alonso, Florian
AU  - Alonso F
AD  - Centre de Recherche Cardio-Thoracique de Bordeaux (INSERM U1045), Universite de 
      Bordeaux, 33076 Bordeaux, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220527
PL  - United States
TA  - Cold Spring Harb Perspect Med
JT  - Cold Spring Harbor perspectives in medicine
JID - 101571139
RN  - 0 (Connexins)
SB  - IM
MH  - *Connexins/metabolism
MH  - *Endothelial Cells
MH  - Gap Junctions/physiology
MH  - Humans
MH  - Neovascularization, Pathologic/metabolism
MH  - Signal Transduction/physiology
PMC - PMC9159259
EDAT- 2022/01/26 06:00
MHDA- 2022/06/01 06:00
PMCR- 2024/05/01
CRDT- 2022/01/25 05:47
PHST- 2022/01/26 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/01/25 05:47 [entrez]
PHST- 2024/05/01 00:00 [pmc-release]
AID - cshperspect.a041158 [pii]
AID - a041158 [pii]
AID - 10.1101/cshperspect.a041158 [doi]
PST - epublish
SO  - Cold Spring Harb Perspect Med. 2022 May 27;12(5):a041158. doi: 
      10.1101/cshperspect.a041158.