PMID- 35075061
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20230116
IS  - 2531-6745 (Electronic)
IS  - 0392-4203 (Print)
IS  - 0392-4203 (Linking)
VI  - 92
IP  - 6
DP  - 2022 Jan 19
TI  - An unusual approach for a cervical mass: sternotomy for the treatment of a giant 
      cervico-thoracic lipoma.
PG  - e2021477
LID - 10.23750/abm.v92i6.12346 [doi]
LID - e2021477
AB  - BACKGROUND AND AIM: Lipoma is a benign mesenchymal tumor. It is a very common 
      tumor and in 13% of cases occurs in head and neck. Giant lipomas are 
      extraordinary and cervical involvement with mediastinal extension is an 
      exceedingly rare presentation. Only a few cases of thoracic extension are 
      reported in literature. METHODS: We describe the case of a 62-years-old man with 
      a giant cervico-mediastinic lipoma which required a combined approach through 
      cervicotomy and sternotomy to ensure surgical radicality. Differential diagnoses 
      could be thymolipoma, liposarcoma or familiar lipomatosis. RESULTS: The mass was 
      removed en-bloc with thymus and locoregional lymph nodes. The patient recovered 
      uneventfully. CONCLUSIONS: The aim of this report is to discuss potential 
      pitfalls of differential diagnosis and implementation of the therapeutic 
      treatment. Focus on the relevance of performing fluorescence in situ 
      hybridization (FISH) for MDM2 amplification is reported, a necessary technique 
      for the differential diagnosis. (www.actabiomedica.it).
FAU - Petruzzi, Gerardo
AU  - Petruzzi G
AD  - Gerardo Petruzzi: Department of Otolaryngology, Head and Neck Surgery, IRCCS 
      Regina Elena National Cancer Institute, Rome, Italy.. petruzzigerardo@gmail.com.
FAU - Trozzi, Lucrezia
AU  - Trozzi L
AD  - Department of Otolaryngology and Head and Neck Surgery, Catholic University of 
      Sacred Heart, Rome, Italy.. lucrezia.trozzi@gmail.com.
FAU - Moretto, Silvia
AU  - Moretto S
AD  - Department of Otolaryngology and Head and Neck Surgery, IRCCS Regina Elena 
      National Cancer Institute, Rome, Italy. silvia.moretto02@gmail.com.
FAU - De Virgilio, Armando
AU  - De Virgilio A
AD  - 3 Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele (MI), Italy. 4 
      Department of Otorhinolaryngology Head and Neck Surgery, IRCCS Humanitas Clinical 
      and Research Center, Via Alessandro Manzoni, 56, 20089 Rozzano (MI), Italy. 
      geddycohen@hotmail.com.
FAU - Melis, Enrico
AU  - Melis E
AD  - Thoracic Surgery Unit, Experimental Clinical Oncology Department, IRCCS Regina 
      Elena National Cancer Institute, Rome, Italy. gerardo.petruzzi@studenti.unipr.it.
FAU - Gallina, Filippo Tommaso
AU  - Gallina FT
AD  - Thoracic Surgery Unit, Experimental Clinical Oncology Department, IRCCS Regina 
      Elena National Cancer Institute, Rome, Italy. filippo.gallina@ifo.gov.it.
FAU - Pichi, Barbara
AU  - Pichi B
AD  - Department of Otolaryngology and Head and Neck Surgery, IRCCS Regina Elena 
      National Cancer Institute, Rome, Italy. petruzzigerardo@gmail.com.
FAU - Campo, Flaminia
AU  - Campo F
AD  - Department of Otolaryngology and Head and Neck Surgery, IRCCS Regina Elena 
      National Cancer Institute, Rome, Italy. petruzzigerardo@gmail.com.
FAU - Facciolo, Francesco
AU  - Facciolo F
AD  - Thoracic Surgery Unit, Experimental Clinical Oncology Department, IRCCS Regina 
      Elena National Cancer Institute, Rome, Italy. gerardo.petruzzi@ifo.gov.it.
FAU - Pellini, Raul
AU  - Pellini R
AD  - Department of Otolaryngology and Head and Neck Surgery, IRCCS Regina Elena 
      National Cancer Institute, Rome, Italy. antonellopetruzzi@libero.it.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220119
PL  - Italy
TA  - Acta Biomed
JT  - Acta bio-medica : Atenei Parmensis
JID - 101295064
SB  - IM
MH  - Diagnosis, Differential
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Lipoma/diagnostic imaging/surgery
MH  - Male
MH  - Middle Aged
MH  - Neck/surgery
MH  - *Sternotomy
PMC - PMC8823560
COIS- Each author declares that he or she has no commercial associations (e.g. 
      consultancies, stock ownership, equity interest, patent/licensing arrangement 
      etc.) that might pose a conflict of interest in connection with the submitted 
      article
EDAT- 2022/01/26 06:00
MHDA- 2022/01/28 06:00
PMCR- 2021/01/01
CRDT- 2022/01/25 05:48
PHST- 2021/10/02 00:00 [received]
PHST- 2021/10/03 00:00 [accepted]
PHST- 2022/01/25 05:48 [entrez]
PHST- 2022/01/26 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - ACTA-92-477 [pii]
AID - 10.23750/abm.v92i6.12346 [doi]
PST - epublish
SO  - Acta Biomed. 2022 Jan 19;92(6):e2021477. doi: 10.23750/abm.v92i6.12346.