PMID- 35075216
OWN - NLM
STAT- MEDLINE
DCOM- 20220308
LR  - 20220308
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jan 24
TI  - Effect of interleukin-1 blockade with anakinra on leukocyte count in patients 
      with ST-segment elevation acute myocardial infarction.
PG  - 1254
LID - 10.1038/s41598-022-05374-w [doi]
LID - 1254
AB  - Leukocytosis is a common finding in patients with ST elevation myocardial 
      infarction (STEMI) and portends a poor prognosis. Interleukin 1-beta regulates 
      leukopoiesis and pre-clinical studies suggest that anakinra (recombinant human 
      interleukin-1 [IL-1] receptor antagonist) suppresses leukocytosis in myocardial 
      infarction. However, the effect of IL-1 blockade with anakinra on leukocyte count 
      in patients with STEMI is unknown. We reviewed the white blood cell (WBC) and 
      differential count of 99 patients enrolled in a clinical trial of anakinra 
      (n = 64) versus placebo (n = 35) for 14 days after STEMI. A complete blood cell 
      count with differential count were obtained at admission, and after 72 h, 14 days 
      and 3 months. After 72 h from treatment, anakinra compared to placebo led to a 
      statistically significant greater percent reduction in total WBC count (- 35% 
      [- 48 to - 24] vs. - 21% [- 34 to - 10], P = 0.008), absolute neutrophil count 
      (- 48% [- 60 to - 22] vs. - 27% [- 46 to - 5], P = 0.004) and to an increase in 
      absolute eosinophil count (+ 50% [0 to + 100] vs. 0% [- 50 to + 62], P = 0.022). 
      These changes persisted while on treatment at 14 days and were no longer apparent 
      at 3 months after treatment discontinuation. We found that in patients with STEMI 
      IL-1 blockade with anakinra accelerates resolution of leukocytosis and 
      neutrophilia. This modulation may represent one of the mechanisms by which IL-1 
      blockade improves clinical outcomes.
CI  - (c) 2022. The Author(s).
FAU - Del Buono, Marco Giuseppe
AU  - Del Buono MG
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
AD  - Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico 
      Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, 
      Italy.
FAU - Damonte, Juan Ignacio
AU  - Damonte JI
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
AD  - Interventional Cardiology Department, Hospital Italiano de Buenos Aires, Buenos 
      Aires, Argentina.
FAU - Trankle, Cory R
AU  - Trankle CR
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
FAU - Kadariya, Dinesh
AU  - Kadariya D
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
FAU - Carbone, Salvatore
AU  - Carbone S
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
AD  - Department of Kinesiology and Health Sciences, College of Humanities and 
      Sciences, Virginia Commonwealth University, Richmond, VA, USA.
FAU - Thomas, Georgia
AU  - Thomas G
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
FAU - Turlington, Jeremy
AU  - Turlington J
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
FAU - Markley, Roshanak
AU  - Markley R
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
FAU - Canada, Justin M
AU  - Canada JM
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
FAU - Biondi-Zoccai, Giuseppe G
AU  - Biondi-Zoccai GG
AD  - Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University 
      of Rome, Latina, Italy.
AD  - Mediterranea Cardiocentro, Naples, Italy.
FAU - Kontos, Michael C
AU  - Kontos MC
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
FAU - Van Tassell, Benjamin W
AU  - Van Tassell BW
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA.
AD  - Department of Pharmacotherapy and Outcome Sciences, School of Pharmacy, Virginia 
      Commonwealth University, Richmond, VA, USA.
FAU - Abbate, Antonio
AU  - Abbate A
AD  - Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, 
      Virginia Commonwealth University, West Hospital, West Wing 5-020, 1200 E Broad 
      Street, P.O. Box 980204, Richmond, VA, 23298, USA. antonio.abbate@vcuhealth.org.
LA  - eng
GR  - 1R34HL121402/NH/NIH HHS/United States
GR  - 1R34HL121402/NH/NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220124
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
SB  - IM
MH  - Aged
MH  - Antirheumatic Agents/*administration & dosage
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein/*administration & dosage
MH  - Leukocyte Count
MH  - Leukocytosis/*drug therapy/etiology
MH  - Male
MH  - Middle Aged
MH  - ST Elevation Myocardial Infarction/*complications
PMC - PMC8786840
COIS- Abbate and Van Tassell have served as consultants to Swedish Orphan Biovitrum LLC 
      in the past. The remaining authors have no disclosures to report.
EDAT- 2022/01/26 06:00
MHDA- 2022/03/09 06:00
PMCR- 2022/01/24
CRDT- 2022/01/25 05:49
PHST- 2021/10/07 00:00 [received]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/01/25 05:49 [entrez]
PHST- 2022/01/26 06:00 [pubmed]
PHST- 2022/03/09 06:00 [medline]
PHST- 2022/01/24 00:00 [pmc-release]
AID - 10.1038/s41598-022-05374-w [pii]
AID - 5374 [pii]
AID - 10.1038/s41598-022-05374-w [doi]
PST - epublish
SO  - Sci Rep. 2022 Jan 24;12(1):1254. doi: 10.1038/s41598-022-05374-w.