PMID- 35076188
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20240405
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 10
IP  - 2
DP  - 2022 Jan
TI  - Plasma miR-21 as a potential predictor in prediabetic individuals with a positive 
      family history of type 2 diabetes mellitus.
PG  - e15163
LID - 10.14814/phy2.15163 [doi]
LID - e15163
AB  - Type 2 diabetes mellitus (T2DM) is a heritable metabolic perturbation, rapidly 
      growing across the world. Primary recognition of susceptible individuals with a 
      family history of type 2 diabetes (FHD) in the prediabetes stage could delay the 
      onset of T2DM or reduce complications induced by diabetes. This study aims to 
      evaluate the expression levels of miR-21, miR-126 as noninvasive predictive 
      biomarkers in individuals with genetic predisposition and investigate the 
      correlation of miRNAs and cardiometabolic risk factors. Our study demonstrated 
      that miR-21 expression has a notable elevate in both groups of T2DM and pre-T2DM. 
      miR-21 expression was distinguished in the pre-T2DM and T2DM from the nondiabetic 
      individuals by ROC curve analysis with AUC of 0.77 (95% CI 0.65-0.90; p = 0.0004) 
      and AUC of 0.78 (95% CI 0.64-0.92; p = 0.0042), respectively. The relative gene 
      expression of miR-126 was nearly equal among groups. miR-21 expression was 
      positively associated with glycosylated hemoglobin (HbA1c), fasting blood sugar 
      (FBS), and triglyceride (TG) and might have diagnostic value for T2DM and 
      pre-T2DM. This study has revealed that the expression level of miR-21 can be 
      considered as a non-invasive and rapid tool for distinguishing pre-T2DM and T2DM 
      counterparts from healthy individuals.
CI  - (c) 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on 
      behalf of The Physiological Society and the American Physiological Society.
FAU - Yazdanpanah, Zakieh
AU  - Yazdanpanah Z
AUID- ORCID: 0000-0003-3787-4089
AD  - Biochemistry Division, Department of Basic Science, School of Veterinary 
      Medicine, Shiraz University, Shiraz, Iran.
FAU - Kazemipour, Nasrin
AU  - Kazemipour N
AUID- ORCID: 0000-0002-2939-1776
AD  - Biochemistry Division, Department of Basic Science, School of Veterinary 
      Medicine, Shiraz University, Shiraz, Iran.
FAU - Kalantar, Seyed Mehdi
AU  - Kalantar SM
AUID- ORCID: 0000-0002-6994-6449
AD  - Department of Medical Genetic, Medical School, Shahid Sadoughi University of 
      Medical Science, Yazd, Iran.
FAU - Vahidi Mehrjardi, Mohammad Yahya
AU  - Vahidi Mehrjardi MY
AUID- ORCID: 0000-0003-0535-1590
AD  - Medical Genetics Research Center, Shahid Sadoughi University of Medical Science, 
      Yazd, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (MIRN21 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Biomarkers
MH  - *Diabetes Mellitus, Type 2/diagnosis/genetics
MH  - Genetic Predisposition to Disease
MH  - Glycated Hemoglobin
MH  - Humans
MH  - *MicroRNAs/metabolism
MH  - *Prediabetic State/diagnosis/genetics
PMC - PMC8787720
OTO - NOTNLM
OT  - family history of type 2 diabetes mellitus
OT  - microRNA-126-3p
OT  - microRNA-21
OT  - prediabetes
COIS- The authors do not have any conflict of interest including any financial, 
      personal, or other relationships with other people or organizations.
EDAT- 2022/01/26 06:00
MHDA- 2022/04/05 06:00
PMCR- 2022/01/25
CRDT- 2022/01/25 08:57
PHST- 2021/12/15 00:00 [revised]
PHST- 2021/10/24 00:00 [received]
PHST- 2021/12/17 00:00 [accepted]
PHST- 2022/01/25 08:57 [entrez]
PHST- 2022/01/26 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2022/01/25 00:00 [pmc-release]
AID - PHY215163 [pii]
AID - 10.14814/phy2.15163 [doi]
PST - ppublish
SO  - Physiol Rep. 2022 Jan;10(2):e15163. doi: 10.14814/phy2.15163.