PMID- 35078079
OWN - NLM
STAT- MEDLINE
DCOM- 20220502
LR  - 20220531
IS  - 1879-1360 (Electronic)
IS  - 0022-3999 (Linking)
VI  - 154
DP  - 2022 Mar
TI  - The impact of partial-oral endocarditis treatment on anxiety and depression in 
      the POET trial.
PG  - 110718
LID - S0022-3999(22)00003-4 [pii]
LID - 10.1016/j.jpsychores.2022.110718 [doi]
AB  - BACKGROUND: The Partial-Oral versus Intravenous Antibiotic Treatment of 
      Endocarditis Trial (POET) found that partial-oral outpatient treatment was 
      non-inferior to conventional in-hospital intravenous treatment in patients with 
      left-sided infective endocarditis. We examined the impact of treatment strategy 
      on levels of anxiety and depression. METHODS: Patients completed the Hospital 
      Anxiety and Depression Scale (HADS) at randomization, at antibiotic completion, 
      and after month 3 and month 6. Changes in anxiety and depression (each 
      subdimension 0-21, high scores indicating worse) were calculated using a repeated 
      measure analysis of covariance model with primary assessment after 6 months. 
      Change in score of 1.7 represented a minimal clinical important difference 
      (MCID). RESULTS: Among the 400 patients enrolled in the POET trial, 263 (66%) 
      completed HADS at randomization with reassessment rates of 86-87% at the three 
      subsequent timepoints. Patients in the partial-oral group and the intravenous 
      group had similar improvements after 6 months in levels of anxiety (-1.8 versus 
      -1.6, P = 0.62) and depression (-2.1 versus -1.9, P = 0.63), although patients in 
      the partial-oral group had numerically lower levels of anxiety and depression 
      throughout. An improvement in MCID scores after 6 months was reported by 47% 
      versus 45% (p = 0.80) patients for anxiety and by 51% versus 54% (p = 0.70) for 
      depression. CONCLUSION: Patients with endocarditis receiving partial-oral 
      outpatient treatment reported similar significant improvements in anxiety and 
      depression at 6 months, as compared to conventionally treated, but numerically 
      lower levels throughout. These findings support the usefulness of partial-oral 
      treatment.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Bundgaard, Johan S
AU  - Bundgaard JS
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark. Electronic address: 
      johan.skov.bundgaard.01@regionh.dk.
FAU - Iversen, Kasper
AU  - Iversen K
AD  - Department of Cardiology, Herlev-Gentofte University Hospital, Copenhagen, 
      Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Pries-Heje, Mia
AU  - Pries-Heje M
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Ihlemann, Nikolaj
AU  - Ihlemann N
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Bak, Theis S
AU  - Bak TS
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Ostergaard, Lauge
AU  - Ostergaard L
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Cardiology, Bispebjerg-Frederiksberg 
      Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Gill, Sabine U
AU  - Gill SU
AD  - Department of Cardiology, Odense University Hospital, Odense, Denmark.
FAU - Madsen, Trine
AU  - Madsen T
AD  - Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
FAU - Elming, Hanne
AU  - Elming H
AD  - Department of Cardiology, Zealand University Hospital, Roskilde, Denmark.
FAU - Jensen, Kaare T
AU  - Jensen KT
AD  - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Bruun, Niels E
AU  - Bruun NE
AD  - Department of Cardiology, Zealand University Hospital, Roskilde, Denmark; 
      Institute of Clinical Medicine, Copenhagen University and Clinical Institute 
      Aalborg University, Denmark.
FAU - Hofsten, Dan E
AU  - Hofsten DE
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Fuursted, Kurt
AU  - Fuursted K
AD  - Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, 
      Denmark.
FAU - Christensen, Jens J
AU  - Christensen JJ
AD  - The Regional Department of Clinical Microbiology, Region Zealand Slagelse 
      Hospital, Department of Clinical Medicine, University of Copenhagen, Copenhagen, 
      Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Schultz, Martin
AU  - Schultz M
AD  - Department of Cardiology, Herlev-Gentofte University Hospital, Copenhagen, 
      Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Rosenvinge, Flemming
AU  - Rosenvinge F
AD  - Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark.
FAU - Schonheyder, Henrik C
AU  - Schonheyder HC
AD  - Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, 
      Denmark.
FAU - Helweg-Larsen, Jannik
AU  - Helweg-Larsen J
AD  - Department of Infectious diseases, Copenhagen University Hospital, University of 
      Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Kober, Lars
AU  - Kober L
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Torp-Pedersen, Christian
AU  - Torp-Pedersen C
AD  - Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; 
      Department of cardiology, Nordsjaellands Hospital, Hillerod, Denmark.
FAU - Fosbol, Emil L
AU  - Fosbol EL
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Tonder, Niels
AU  - Tonder N
AD  - Department of Cardiology, North Zealand University Hospital, Hillerod, Denmark; 
      Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
FAU - Moser, Claus
AU  - Moser C
AD  - Department of Clinical Microbiology, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Immunology and Microbiology, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Bundgaard, Henning
AU  - Bundgaard H
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Mogensen, Ulrik M
AU  - Mogensen UM
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University 
      Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20220113
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Administration, Oral
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Anxiety/drug therapy
MH  - *Depression/drug therapy
MH  - *Endocarditis/drug therapy
MH  - Humans
OTO - NOTNLM
OT  - Antibiotic
OT  - Anxiety
OT  - Cardiovascular disease
OT  - Depression
OT  - Endocarditis
EDAT- 2022/01/26 06:00
MHDA- 2022/05/03 06:00
CRDT- 2022/01/25 20:16
PHST- 2021/04/12 00:00 [received]
PHST- 2022/01/04 00:00 [revised]
PHST- 2022/01/05 00:00 [accepted]
PHST- 2022/01/26 06:00 [pubmed]
PHST- 2022/05/03 06:00 [medline]
PHST- 2022/01/25 20:16 [entrez]
AID - S0022-3999(22)00003-4 [pii]
AID - 10.1016/j.jpsychores.2022.110718 [doi]
PST - ppublish
SO  - J Psychosom Res. 2022 Mar;154:110718. doi: 10.1016/j.jpsychores.2022.110718. Epub 
      2022 Jan 13.