PMID- 35079406
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240405
IS  - 2052-6113 (Print)
IS  - 2052-6113 (Electronic)
IS  - 2052-6113 (Linking)
VI  - 9
IP  - 1
DP  - 2022 Dec
TI  - Toceranib phosphate in the management of canine insulinoma: A retrospective 
      multicentre study of 30 cases (2009-2019).
PG  - e27
LID - 10.1002/vro2.27 [doi]
LID - e27
AB  - BACKGROUND: Insulinomas are the most common tumour of the endocrine pancreas in 
      dogs. These malignant tumours have a high metastatic rate and limited 
      chemotherapeutic options. The multi-receptor tyrosine kinase inhibitor sunitinib 
      malate has benefit in the treatment of metastatic insulinoma in people. Toceranib 
      phosphate, an analogous veterinary agent, may provide benefit for dogs. METHODS: 
      A retrospective study describing the extent and duration of clinical outcomes and 
      adverse events (AEs) in dogs diagnosed with insulinoma and receiving toceranib. 
      RESULTS: Records for 30 dogs diagnosed with insulinoma and having received 
      toceranib were identified from a medical record search of five university and 
      eight referral hospitals. The median progression-free interval and overall 
      survival time were 561 days (95% confidence interval (CI): [246, 727 days]) and 
      656 days (95% CI: [310, 1045 days]), respectively. Of the dogs for which the 
      canine Response evaluation criteria for solid tumours tool could be applied, the 
      majority (66.7%) showed either a complete response, partial response or stable 
      disease. Time to clinical progression was associated with prior intervention and 
      type of veterinary practice. Larger dogs were at increased risk for disease 
      progression and death. No novel AEs were reported. CONCLUSIONS: Most dogs 
      diagnosed with insulinoma and receiving toceranib appeared to have a clinical 
      benefit. Randomised, prospective studies are needed to better elucidate and 
      objectively quantify the potential effect and survival benefit of toceranib 
      therapy for management of insulinoma in dogs.
CI  - (c) 2022 The Authors. Veterinary Record Open published by John Wiley & Sons Ltd on 
      behalf of British Veterinary Association.
FAU - Sheppard-Olivares, Sabina
AU  - Sheppard-Olivares S
AUID- ORCID: 0000-0001-8560-8995
AD  - Department of Clinical Sciences College of Veterinary Medicine Kansas State 
      University Manhattan Kansas USA.
AD  - Present address: 3901 Guadalupe Street, Austin, TX 78751, USA.
FAU - Bello, Nora M
AU  - Bello NM
AD  - Department of Statistics College of Arts and Sciences Kansas State University 
      Manhattan Kansas USA.
FAU - Johannes, Chad M
AU  - Johannes CM
AUID- ORCID: 0000-0003-1855-6966
AD  - Department of Clinical Sciences College of Veterinary Medicine Iowa State 
      University Ames Iowa USA.
FAU - Hocker, Samuel E
AU  - Hocker SE
AD  - Ontario Veterinary College University of Guelph Guelph Ontario Canada.
AD  - Present address: Department of Clinical Sciences, College of Veterinary Medicine, 
      Kansas State University, 1800 Denison Avenue, Manhattan, KS 66506, USA.
FAU - Biller, Barbara
AU  - Biller B
AD  - Flint Animal Cancer Center College of Veterinary Medicine and Biomedical Sciences 
      Colorado State University Fort Collins Colorado USA.
AD  - Present address: 4120 Clydesdale Pkwy, Loveland, CO 80538, USA.
FAU - Husbands, Brian
AU  - Husbands B
AD  - Veterinary Clinical Sciences Department College of Veterinary Medicine University 
      of Minnesota St. Paul Minnesota USA.
AD  - Present address: Department of Veterinary Clinical Sciences, College of 
      Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 
      43210, USA.
FAU - Snyder, Elizabeth
AU  - Snyder E
AD  - Department of Medical Sciences School of Veterinary Medicine University of 
      Wisconsin-Madison Madison Wisconsin USA.
AD  - Present address: BluePearl Specialty and Emergency Pet Hospital, 1646 Spring 
      Cypress Rd Ste 100, Spring, TX 77388, USA.
FAU - McMillan, Mattison
AU  - McMillan M
AD  - Las Vegas Veterinary Specialty Center Las Vegas Nevada USA.
AD  - Present address: College of Veterinary Medicine, Washington State University, 
      Pullman, WA 99164, USA.
FAU - McKee, Talon
AU  - McKee T
AD  - Clinical Studies Department VCA Inc. Los Angeles California USA.
FAU - Wouda, Raelene M
AU  - Wouda RM
AUID- ORCID: 0000-0001-5765-6500
AD  - Department of Clinical Sciences College of Veterinary Medicine Kansas State 
      University Manhattan Kansas USA.
LA  - eng
PT  - Journal Article
DEP - 20220120
PL  - United States
TA  - Vet Rec Open
JT  - Veterinary record open
JID - 101653671
PMC - PMC8776903
COIS- The authors declare they have no conflicts of interest.
EDAT- 2022/01/27 06:00
MHDA- 2022/01/27 06:01
PMCR- 2022/01/20
CRDT- 2022/01/26 05:30
PHST- 2021/05/06 00:00 [received]
PHST- 2021/09/28 00:00 [revised]
PHST- 2021/11/22 00:00 [accepted]
PHST- 2022/01/26 05:30 [entrez]
PHST- 2022/01/27 06:00 [pubmed]
PHST- 2022/01/27 06:01 [medline]
PHST- 2022/01/20 00:00 [pmc-release]
AID - VRO227 [pii]
AID - 10.1002/vro2.27 [doi]
PST - epublish
SO  - Vet Rec Open. 2022 Jan 20;9(1):e27. doi: 10.1002/vro2.27. eCollection 2022 Dec.