PMID- 35079723
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 2666-6022 (Electronic)
IS  - 2666-6022 (Linking)
VI  - 12
DP  - 2021 Dec
TI  - Circulating fibrocyte levels correlate with infarct size in patients with ST 
      elevation myocardial infarction treated with primary percutaneous coronary 
      intervention.
LID - 100071 [pii]
LID - 10.1016/j.ahjo.2021.100071 [doi]
AB  - STUDY OBJECTIVE: Infarct size is a strong predictor of outcomes after ST 
      elevation myocardial infarction (STEMI). Circulating fibrocytes are bone 
      marrow-derived progenitor cells associated with fibrotic processes. We tested 
      whether fibrocytes correlate with infarct size in STEMI patients treated with 
      primary percutaneous coronary intervention (PCI). DESIGN: Prospective 
      observational study. SETTING: Academic medical center. PARTICIPANTS: Subjects 
      with STEMI treated with primary PCI. INTERVENTIONS: Peripheral blood draw and 
      cardiac magnetic resonance imaging (CMR). MAIN OUTCOME MEASURE: Correlation of 
      fibrocyte levels with infarct size. METHODS: Peripheral blood fibrocytes were 
      quantified at discharge from STEMI hospitalization and at 6 months follow-up 
      using flow cytometry. Infarct size was determined within 2 weeks of discharge and 
      at 6 months follow-up using late gadolinium enhancement on CMR. RESULTS: Among 14 
      patients (median age 54 years, 79% men) with STEMI, there was a statistically 
      significant positive correlation between fibrocyte levels at 6 months and 6-month 
      infarct size on CMR (r = 0.58, p = 0.031). In addition, there was positive 
      correlation between peak troponin I level (r = 0.85, p < 0.001), and white blood 
      cell count (r = 0.55, p = 0.042) during the hospital stay and 6-month infarct 
      size on CMR. CONCLUSIONS: Circulating fibrocytes measured 6 months after STEMI 
      positively correlate with 6-month infarct size assessed by CMR.
FAU - Elzeneini, Mohammed
AU  - Elzeneini M
AD  - Department of Medicine, University of Florida, Gainesville, FL, USA.
AD  - Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.
FAU - Al-Ani, Mohammad
AU  - Al-Ani M
AD  - Department of Medicine, University of Florida, Gainesville, FL, USA.
AD  - Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.
FAU - Peters, Anthony E
AU  - Peters AE
AD  - Department of Internal Medicine, University of Virginia, Charlottesville, VA, 
      USA.
FAU - Burdick, Marie D
AU  - Burdick MD
AD  - Department of Internal Medicine, University of Virginia, Charlottesville, VA, 
      USA.
FAU - Yang, Ning
AU  - Yang N
AD  - Department of Medicine, University of Florida, Gainesville, FL, USA.
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, 
      Gainesville, FL, USA.
FAU - Salerno, Michael
AU  - Salerno M
AD  - Department of Internal Medicine, University of Virginia, Charlottesville, VA, 
      USA.
AD  - Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, 
      USA.
FAU - Mehrad, Borna
AU  - Mehrad B
AD  - Department of Medicine, University of Florida, Gainesville, FL, USA.
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, 
      Gainesville, FL, USA.
FAU - Keeley, Ellen C
AU  - Keeley EC
AD  - Department of Medicine, University of Florida, Gainesville, FL, USA.
AD  - Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.
LA  - eng
GR  - R01 AI135128/AI/NIAID NIH HHS/United States
GR  - R01 HL098329/HL/NHLBI NIH HHS/United States
GR  - U01 EB024501/EB/NIBIB NIH HHS/United States
PT  - Journal Article
DEP - 20211127
PL  - United States
TA  - Am Heart J Plus
JT  - American heart journal plus : cardiology research and practice
JID - 101779333
PMC - PMC8786221
MID - NIHMS1770793
OTO - NOTNLM
OT  - Biomarker
OT  - Fibrocyte
OT  - Infarct size
OT  - ST elevation myocardial infarction
COIS- Declaration of competing interest No authors reported conflict of interest.
EDAT- 2022/01/27 06:00
MHDA- 2022/01/27 06:01
PMCR- 2021/11/27
CRDT- 2022/01/26 05:31
PHST- 2022/01/26 05:31 [entrez]
PHST- 2022/01/27 06:00 [pubmed]
PHST- 2022/01/27 06:01 [medline]
PHST- 2021/11/27 00:00 [pmc-release]
AID - 100071 [pii]
AID - 10.1016/j.ahjo.2021.100071 [doi]
PST - ppublish
SO  - Am Heart J Plus. 2021 Dec;12:100071. doi: 10.1016/j.ahjo.2021.100071. Epub 2021 
      Nov 27.