PMID- 35079900
OWN - NLM
STAT- MEDLINE
DCOM- 20220216
LR  - 20220216
IS  - 1432-8798 (Electronic)
IS  - 0304-8608 (Linking)
VI  - 167
IP  - 2
DP  - 2022 Feb
TI  - Comparison of the pathogenicity of porcine reproductive and respiratory syndrome 
      virus (PRRSV)-1 and PRRSV-2 in pregnant sows.
PG  - 425-439
LID - 10.1007/s00705-021-05303-8 [doi]
AB  - To date, few studies related to the evaluation of the pathogenicity of different 
      PRRSV isolates using a reproductive model have been undertaken, and the main 
      focus has remained on respiratory models using young pigs. This study aimed to 
      evaluate the pathogenicity of two PRRSV-1 isolates (D40 and CBNU0495) and two 
      PRRSV-2 isolates (K07-2273 and K08-1054) in a reproductive model. Pregnant sows 
      were experimentally infected with PRRSV at gestational day 93 or used as an 
      uninfected negative control. Sera were collected at 0, 3, 7, 14, and 19 days 
      post-challenge (dpc) for virological and serological assays. At 19 dpc, all sows 
      were euthanized, and their fetuses were recovered by performing cesarean section 
      and immediately euthanized for sample collection. Here, compared to the other 
      isolates, the CBNU0495 isolate replicated most efficiently in the pregnant sows, 
      and K07-2273 produced the highest rate of reproductive failure even though it did 
      not replicate as efficiently as the other isolates in sows and fetuses, 
      indicating that vertical transmission and reproductive failure due to PRRSV 
      infection do not have any significant correlation with the viral loads in samples 
      from sows and fetuses. Similarly, the viral loads and the histopathological 
      lesions did not show any correlation with each other, as the PRRSV-2-infected 
      groups displayed more prominent and frequent histopathological lesions with lower 
      viral loads than the PRRSV-1-infected groups. However, viral loads in the 
      myometrium/endometrium might be related to the spreading of PRRSV in the fetuses, 
      which affected the birth weight of live fetuses. This study contributes to a 
      better understanding of the pathogenicity of the most prevalent Korean PRRSVs in 
      a reproductive model.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, 
      part of Springer Nature.
FAU - Jeong, Chang-Gi
AU  - Jeong CG
AD  - College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan, 
      Jeonbuk, 54596, Republic of Korea.
FAU - Nazki, Salik
AU  - Nazki S
AD  - College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan, 
      Jeonbuk, 54596, Republic of Korea.
AD  - The Pirbright Institute, Pirbright, UK.
FAU - Kim, Seung-Chai
AU  - Kim SC
AD  - College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan, 
      Jeonbuk, 54596, Republic of Korea.
FAU - Khatun, Amina
AU  - Khatun A
AD  - College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan, 
      Jeonbuk, 54596, Republic of Korea.
AD  - Department of Pathology, Faculty of Animal Science and Veterinary Medicine, 
      Sher-e-Bangla Agricultural University, Sher-e-Bangla Nagar, Dhaka, 1207, 
      Bangladesh.
FAU - Noh, Yun-Hee
AU  - Noh YH
AD  - ChoongAng Vaccine Laboratory, Daejeon, 34055, Republic of Korea.
FAU - Lee, Dong-Uk
AU  - Lee DU
AD  - ChoongAng Vaccine Laboratory, Daejeon, 34055, Republic of Korea.
FAU - Kang, Sang Chul
AU  - Kang SC
AD  - Optipharm Inc., Cheongju, 28158, Republic of Korea.
FAU - Seo, Byoung-Joo
AU  - Seo BJ
AD  - College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan, 
      Jeonbuk, 54596, Republic of Korea.
FAU - Yang, Myeon-Sik
AU  - Yang MS
AD  - College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan, 
      Jeonbuk, 54596, Republic of Korea.
FAU - Lee, Sim-In
AU  - Lee SI
AD  - College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan, 
      Jeonbuk, 54596, Republic of Korea.
FAU - Yoon, In-Joong
AU  - Yoon IJ
AD  - ChoongAng Vaccine Laboratory, Daejeon, 34055, Republic of Korea.
FAU - Kim, Bumseok
AU  - Kim B
AD  - College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan, 
      Jeonbuk, 54596, Republic of Korea. bskims@jbnu.ac.kr.
FAU - Kim, Won-Il
AU  - Kim WI
AUID- ORCID: 0000-0002-0465-0794
AD  - College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan, 
      Jeonbuk, 54596, Republic of Korea. kwi0621@jbnu.ac.kr.
LA  - eng
GR  - 118093-03/Animal Disease Management Technology Development Program/
GR  - 321015-01-1/Animal Disease Management Technology Development Program/
PT  - Journal Article
DEP - 20220126
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
SB  - IM
MH  - Animals
MH  - Cesarean Section
MH  - Female
MH  - Infectious Disease Transmission, Vertical
MH  - *Porcine Reproductive and Respiratory Syndrome
MH  - *Porcine respiratory and reproductive syndrome virus/genetics
MH  - Pregnancy
MH  - Swine
MH  - Virulence
EDAT- 2022/01/27 06:00
MHDA- 2022/02/17 06:00
CRDT- 2022/01/26 05:32
PHST- 2021/05/24 00:00 [received]
PHST- 2021/10/06 00:00 [accepted]
PHST- 2022/01/27 06:00 [pubmed]
PHST- 2022/02/17 06:00 [medline]
PHST- 2022/01/26 05:32 [entrez]
AID - 10.1007/s00705-021-05303-8 [pii]
AID - 10.1007/s00705-021-05303-8 [doi]
PST - ppublish
SO  - Arch Virol. 2022 Feb;167(2):425-439. doi: 10.1007/s00705-021-05303-8. Epub 2022 
      Jan 26.