PMID- 35083387
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220128
IS  - 2434-0790 (Electronic)
IS  - 2434-0790 (Linking)
VI  - 4
IP  - 1
DP  - 2022 Jan 7
TI  - Local Injection of Hydroxyapatite Electret Ameliorated Infarct Size After 
      Myocardial Infarction.
PG  - 38-47
LID - 10.1253/circrep.CR-21-0100 [doi]
AB  - Background: Previous studies showed that hydroxyapatite electret (HAE) 
      accelerates the regeneration of vascular endothelial cells and angiogenesis. This 
      study investigated the effects of HAE in myocardial infarction (MI) model mice. 
      Methods and Results: MI was induced in mice by ligating the left anterior 
      descending artery. Immediately after ligation, HAE, non-polarized hydroxyapatite 
      (HAN), or water (control) was injected into the infarct border myocardium. 
      Functional and histological analyses were performed 2 weeks later. 
      Echocardiography revealed that HAE injection preserved left ventricular systolic 
      function and the wall thickness of the scar, whereas HAN-injected mice had 
      impaired cardiac function and thinning of the wall, similar to control mice. 
      Histological assessment showed that HAE injection significantly attenuated the 
      length of the scar lesion. There was significant accumulation of CD31-positive 
      cells and increased expression of vascular endothelial growth factor (Vegf), 
      intercellular adhesion molecule-1 (Icam1), vascular cell adhesion molecule-1 
      (Vcam1), hypoxia-inducible factor-1alpha (Hif1a), and C-X-C motif chemokine ligand 12 
      (Cxcl12) genes in the infarct border zone of HAE-injected mice. These effects 
      were not induced by HAN injection. Anti-VEGFR2 antibody canceled the beneficial 
      effect of HAE. In vitro experiments in a human cardiovascular endothelial cell 
      line showed that HAE dose-dependently increased VEGFA expression. Conclusions: 
      Local injection of HAE attenuated infarct size and improved cardiac function 
      after MI, probably due to angiogenesis. The electric charge of HAE may stimulate 
      angiogenesis via HIF1alpha-CXCL12/VEGF signaling.
CI  - Copyright (c) 2022, THE JAPANESE CIRCULATION SOCIETY.
FAU - Yamaguchi, Junji
AU  - Yamaguchi J
AD  - Department of Cardiovascular Medicine, Tokyo Medical and Dental University Tokyo 
      Japan.
FAU - Chiba, Risako
AU  - Chiba R
AD  - Department of Cardiovascular Physiology, Tokyo Medical and Dental University 
      Tokyo Japan.
FAU - Komuro, Hiroaki
AU  - Komuro H
AD  - Department of Cardiovascular Physiology, Tokyo Medical and Dental University 
      Tokyo Japan.
FAU - Ihara, Kensuke
AU  - Ihara K
AD  - Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo 
      Medical and Dental University Tokyo Japan.
FAU - Nozaki, Kosuke
AU  - Nozaki K
AD  - Department of Fixed Prosthodontics, Graduate School of Medical and Dental 
      Sciences, Tokyo Medical and Dental University Tokyo Japan.
FAU - Nagai, Akiko
AU  - Nagai A
AD  - Department of Anatomy, Aichi-Gakuin University School of Dentistry Nagoya Japan.
FAU - Furukawa, Tetsushi
AU  - Furukawa T
AD  - Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo 
      Medical and Dental University Tokyo Japan.
FAU - Sasano, Tetsuo
AU  - Sasano T
AD  - Department of Cardiovascular Medicine, Tokyo Medical and Dental University Tokyo 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20211201
PL  - Japan
TA  - Circ Rep
JT  - Circulation reports
JID - 101746642
PMC - PMC8710644
OTO - NOTNLM
OT  - Angiogenesis
OT  - Hydroxyapatite electret
OT  - Myocardial infarction
OT  - Ventricular remodeling
COIS- The authors have no conflicts of interest to declare.
EDAT- 2022/01/28 06:00
MHDA- 2022/01/28 06:01
PMCR- 2021/12/01
CRDT- 2022/01/27 05:50
PHST- 2021/07/16 00:00 [received]
PHST- 2021/11/01 00:00 [revised]
PHST- 2021/11/04 00:00 [accepted]
PHST- 2022/01/27 05:50 [entrez]
PHST- 2022/01/28 06:00 [pubmed]
PHST- 2022/01/28 06:01 [medline]
PHST- 2021/12/01 00:00 [pmc-release]
AID - 10.1253/circrep.CR-21-0100 [doi]
PST - epublish
SO  - Circ Rep. 2021 Dec 1;4(1):38-47. doi: 10.1253/circrep.CR-21-0100. eCollection 
      2022 Jan 7.