PMID- 35083784
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220407
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 36
IP  - 3
DP  - 2022 Mar
TI  - Association of end-stage renal disease with HLA phenotypes and panel reactive 
      antibodies in patients awaiting renal transplantation in Hunan Province.
PG  - e24251
LID - 10.1002/jcla.24251 [doi]
LID - e24251
AB  - OBJECTIVES: To explore the immune-related genetic susceptibility of human 
      leukocyte antigen (HLA) alleles and their correlation with panel reactive 
      antibody (PRA) generation during end-stage renal disease (ESRD) progression. 
      MATERIALS AND METHODS: Data of the expression patterns of HLA-A, -B, and -DR 
      alleles and PRAs of 347 ESRD patients awaiting renal transplantation in Hunan 
      Province from 2015 to 2019 were retrospectively studied. The polymerase chain 
      reaction with sequence-specific primers was used for HLA genotyping and the 
      enzyme-linked immunosorbent assay for PRA detection. SPSS 21.0 software was used 
      for all allele frequency and statistical analyses. RESULTS: Thirteen HLA-A, 25 
      HLA-B, and 13 HLA-DR alleles were expressed. The allele frequencies of HLA-A2, 
      -B48, -B52, and -B55 were significantly higher in the case group than in the 
      control group (p < 0.05), whereas that of HLA-B60 was significantly higher in the 
      control group (p < 0.05). The frequency of HLA alleles in the PRA-positive group 
      was significantly higher in females than in males (p < 0.05). The allele 
      frequencies of HLA-A2, -B38, and -B46 were significantly higher in the 
      PRA-positive group than in the PRA-negative one (p < 0.05), whereas that of 
      HLA-60 was significantly higher in the PRA-negative group (p < 0.05). CONCLUSION: 
      HLA-A2, -B48, -B52, and -B55 may be the ESRD susceptibility alleles in Han 
      Chinese patients in Hunan Province, whereas HLA-B60 may be the protective allele. 
      Patients carrying HLA-A2, -B38, and -B46 are more likely to develop PRA 
      positivity, whereas the opposite is true for those with HLA-B60.
CI  - (c) 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley 
      Periodicals LLC.
FAU - Long, Lu
AU  - Long L
AD  - Department of Clinical Laboratory, Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Sun, Qian
AU  - Sun Q
AUID- ORCID: 0000-0001-5839-6341
AD  - Department of Clinical Laboratory, Xiangya Hospital, Central South University, 
      Changsha, China.
LA  - eng
PT  - Journal Article
DEP - 20220126
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
SB  - IM
MH  - Alleles
MH  - Female
MH  - HLA Antigens/genetics
MH  - HLA-A Antigens/genetics
MH  - Humans
MH  - *Kidney Failure, Chronic/genetics/surgery
MH  - *Kidney Transplantation
MH  - Male
MH  - Phenotype
MH  - Retrospective Studies
PMC - PMC8906009
OTO - NOTNLM
OT  - HLA phenotypes
OT  - end-stage renal disease
OT  - panel reactive antibodies
OT  - polymorphism
EDAT- 2022/01/28 06:00
MHDA- 2022/04/08 06:00
PMCR- 2022/01/26
CRDT- 2022/01/27 05:52
PHST- 2021/12/31 00:00 [revised]
PHST- 2021/11/15 00:00 [received]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/01/28 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
PHST- 2022/01/27 05:52 [entrez]
PHST- 2022/01/26 00:00 [pmc-release]
AID - JCLA24251 [pii]
AID - 10.1002/jcla.24251 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2022 Mar;36(3):e24251. doi: 10.1002/jcla.24251. Epub 2022 Jan 
      26.