PMID- 35084309 OWN - NLM STAT- MEDLINE DCOM- 20220923 LR - 20220927 IS - 0392-856X (Print) IS - 0392-856X (Linking) VI - 40 IP - 9 DP - 2022 Sep TI - Adherence of Italian rheumatologists to the EULAR recommendations and outcomes in early rheumatoid arthritis patients after starting conventional DMARDs: Methotrexate in Italian patients wiTh Rheumatoid Arthritis (the MITRA study). A cohort study of the Italian Society for Rheumatology. PG - 1693-1700 LID - 10.55563/clinexprheumatol/77i56a [doi] AB - OBJECTIVES: The aim of this study was to assess the real-life adherence of Italian rheumatologist to the 2013 EULAR recommendations and treatment outcome in rheumatoid arthritis (RA) patients who started a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD). METHODS: The MITRA study is an Italian multicentre observational cohort focused on treatment naive RA patients with early diagnosis recruited in an 18-month period starting from 2015. The data related to treatment with csDMARDs during the following 12 months follow-up were presented in this paper. RESULTS: Two-hundred and fifty-nine RA patients from MITRA cohort who had a follow-up visit and started a csDMARD were included in the prospective analysis. Methotrexate was started as first conventional DMARD in 224 (86.4%) patients. During the first year after starting conventional DMARDs, 175 (67.6%) RA patients reached the pre-specified target, which was DAS28 remission (<2.6) for 112 (43.2%) patients and LDA (<3.2) for 63 (24.3%) patients. Factors that negatively impacted the target achievement were fibromyalgia (HR: 0.2 [0.05-0.81]), HAQ-DI (HR: 0.72 [0.56-0.93]) and ESR (HR: 0.99 [0.99-1]). Globally, 33 (12.7%) patients started a biologic DMARD, while 61 out of 84 (72.6%) patients who had never reached the target remained on conventional DMARD. One-hundred and ninety-three adverse events (AEs) were recorded, the majority classified as mild (91 cases, 51%). CONCLUSIONS: A high proportion of RA patients achieved the target during the first-year follow-up. However, a considerable portion of RA patients did not start a biological drug although the target was never reached. AEs remain frequent with conventional DMARDs, but the majority were mild. FAU - Fornaro, Marco AU - Fornaro M AD - Rheumatology Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari, Italy. FAU - Benaglio, Francesca AU - Benaglio F AD - Division of Rheumatology, IRCCS Policlinico San Matteo Foundation, University of Pavia, Italy. FAU - Montecucco, Carlomaurizio AU - Montecucco C AD - Division of Rheumatology, IRCCS Policlinico San Matteo Foundation, University of Pavia, Italy. FAU - Raffeiner, Bernd AU - Raffeiner B AD - Rheumatology, Central Hospital of Bolzano, Italy. FAU - Di Franco, Manuela AU - Di Franco M AD - Rheumatology Unit, Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Sapienza University of Rome, AOU Policlinico Umberto I, Rome, Italy. FAU - Iannuccelli, Cristina AU - Iannuccelli C AD - Rheumatology Unit, Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Sapienza University of Rome, AOU Policlinico Umberto I, Rome, Italy. FAU - Conigliaro, Paola AU - Conigliaro P AD - Rheumatology Unit, Allergology and Clinical Immunology, University of Rome Tor Vergata, Rome, Italy. FAU - Lomater, Claudia AU - Lomater C AD - Rheumatology Unit, Mauriziano Hospital, Turin, Italy. FAU - Govoni, Marcello AU - Govoni M AD - Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy. FAU - Silvagni, Ettore AU - Silvagni E AD - Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy. FAU - Zanetti, Anna AU - Zanetti A AD - Epidemiology Unit, Italian Society for Rheumatology (SIR), Milan, and Department of Statistics and Quantitative Methods, Division of Biostatistics, Epidemiology and Public Health, University of Milano-Bicocca, Milan, Italy. FAU - Parisi, Simone AU - Parisi S AD - Epidemiology Unit, Italian Society for Rheumatology (SIR), Milan, and Rheumatology Unit, AOU Citta della Salute e della Scienza di Torino, Turin, Italy. FAU - Carrara, Greta AU - Carrara G AD - Epidemiology Unit, Italian Society for Rheumatology (SIR), Milan, Italy. FAU - Scire, Carlo Alberto AU - Scire CA AD - Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria di Ferrara, Cona, and Epidemiology Unit, Italian Society for Rheumatology (SIR), Milan, Italy. FAU - Caporali, Roberto AU - Caporali R AD - Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, and Department of Clinical Sciences and Community Health, Research Center for Adult and Paediatric Rheumatic Diseases, Universita degli Studi di Milano, Italy. FAU - Iannone, Florenzo AU - Iannone F AD - Rheumatology Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari, Italy. florenzo.iannone@uniba.it. LA - eng PT - Journal Article DEP - 20220112 PL - Italy TA - Clin Exp Rheumatol JT - Clinical and experimental rheumatology JID - 8308521 RN - 0 (Antirheumatic Agents) RN - 0 (Biological Products) RN - YL5FZ2Y5U1 (Methotrexate) SB - IM MH - *Antirheumatic Agents MH - *Arthritis, Rheumatoid/diagnosis/drug therapy MH - *Biological Products MH - Cohort Studies MH - Humans MH - Methotrexate MH - Rheumatologists MH - *Rheumatology MH - Treatment Outcome EDAT- 2022/01/28 06:00 MHDA- 2022/09/24 06:00 CRDT- 2022/01/27 12:14 PHST- 2021/07/18 00:00 [received] PHST- 2021/10/18 00:00 [accepted] PHST- 2022/01/28 06:00 [pubmed] PHST- 2022/09/24 06:00 [medline] PHST- 2022/01/27 12:14 [entrez] AID - 17698 [pii] AID - 10.55563/clinexprheumatol/77i56a [doi] PST - ppublish SO - Clin Exp Rheumatol. 2022 Sep;40(9):1693-1700. doi: 10.55563/clinexprheumatol/77i56a. Epub 2022 Jan 12.