PMID- 35084725
OWN - NLM
STAT- Publisher
LR  - 20240220
IS  - 2543-6031 (Electronic)
IS  - 2451-4934 (Linking)
DP  - 2022 Jan 27
TI  - Interleukin-26 is associated with the level of systemic inflammation and lung 
      functions in obese and non-obese moderate-to-severe asthmatic patients.
LID - 10.5603/ARM.a2022.0006 [doi]
AB  - INTRODUCTION: Obese asthma is a complex syndrome, which includes different 
      phenotypes of disease. At present, these phenotypes only have started to acquire 
      a sufficient understanding. It was suggested that IL-26 is a potential biomarker 
      of disease severity in asthma without signs of Th2-mediated inflammation. In this 
      study, we investigated the serum and exhaled levels of IL-26 and its associations 
      with the level of systemic inflammation, lung functions, and body weight in obese 
      and non-obese moderate-to-severe asthmatic patients MATERIAL AND METHODS: The 
      study included 10 healthy subjects, 10 obese subjects without lung pathologies, 
      10 non-obese asthmatics (NOA) (BMI 18.5-24.9 kg/m(2)), and 40 obese asthmatics (OA) 
      (BMI 25.0-49.9 kg/m(2)). During the visit, patients' examination and spirometry 
      with the bronchodilator reversibility test were conducted, the exhaled breath 
      condensate (EBC) was obtained, and the blood samples were collected. The level of 
      IL-26, interleukin-1beta (IL-1beta), interleukin-4 (IL-4), interleukin-6 (IL-6), TNF-alpha, 
      interleukin-10 (IL-10), total and specific immunoglobulin E (IgE), and high 
      sensitive C reactive protein (hs-CRP) were measured using the ELISA kits. 
      Statistical comparison between 2 groups was analyzed using the Mann-Whitney 
      rank-sum test. Chi-square with Yates' correction was used to compare frequencies. 
      Spearman's rank test was used for correlating nonparametric variables. The 
      Receiver Operating Characteristic (ROC) curve and the area under ROC curve (AUC) 
      were used for evaluating the diagnostic power of IL-26 as a possible biomarker. 
      RESULTS: NOA had a reversible airway obstruction with reduced FEV1, FEV1/FVC, FVC 
      25/75, and positive post-bronchodilator test (PBT), significantly increased serum 
      levels of IL-10, IL-4, and slightly increased IL-26. NOA had significantly 
      increased exhaled IL-26 in comparison with healthy subjects. The obese subjects 
      had a normal ventilatory pattern without airway obstruction, and differences in 
      serum IL-26, IL-10, and IL-4 concentrations in comparison with healthy subjects. 
      Obese subjects had a significant escalation of hs-CRP and no differences in the 
      levels of exhaled IL-26, IL-10, and hs-CRP as compared with healthy subjects. OA 
      had reduced FEV1, FEV1/FVC, and FEV25-75 in comparison with non-obese asthmatics. 
      OA had elevated IL-26, IL-10, IL-4, and hs-CRP concentrations as compared with 
      healthy subjects. These patients had a partial similarity with both non-obese 
      asthmatics (elevated IL-26, IL-10, and IL-4) and obese subjects (elevated, IL-1beta, 
      IL-6, TNF-alpha, hs-CRP). OA had a reduced concentration of exhaled IL-26 in 
      comparison with NOA and elevated exhaled IL-10 in comparison with obese subjects. 
      Furthermore, OA had an increased concentration of IL-1beta and TNF-alpha in comparison 
      with healthy individuals and NOA. Exhaled IL-26 concentration distinguished 
      non-obese asthmatics from healthy subjects, asthmatic patients from 
      non-asthmatics (healthy and obese subjects), all asthmatic patients from 
      non-asthmatics (healthy and obese subjects). CONCLUSIONS: Exhaled IL-26 elevated 
      in obese and non-obese moderate-to-severe asthmatic patients. Exhaled IL-26 might 
      be a perspective biomarker in non-obese and obese asthmatics. The obese asthmatic 
      phenotype comprised the combined systemic and local airway inflammation.
FAU - Avramenko, Yanina
AU  - Avramenko Y
AUID- ORCID: 0000-0003-4166-7824
AD  - Poltava State Medical University, Poltava, Ukraine.
FAU - Izmailova, Olha
AU  - Izmailova O
AUID- ORCID: 0000-0002-2905-1827
AD  - Poltava State Medical University, Poltava, Ukraine.
FAU - Shlykova, Oksana
AU  - Shlykova O
AUID- ORCID: 0000-0002-6764-2767
AD  - Poltava State Medical University, Poltava, Ukraine.
FAU - Kaidashev, Igor
AU  - Kaidashev I
AUID- ORCID: 0000-0002-4708-0859
AD  - Poltava State Medical University, Poltava, Ukraine. kaydashevip@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220127
PL  - Switzerland
TA  - Adv Respir Med
JT  - Advances in respiratory medicine
JID - 101697329
SB  - IM
OTO - NOTNLM
OT  - asthma
OT  - interleukin-26
OT  - obesity
OT  - systemic inflammation
EDAT- 2022/01/28 06:00
MHDA- 2022/01/28 06:00
CRDT- 2022/01/27 12:18
PHST- 2021/02/04 00:00 [received]
PHST- 2021/12/14 00:00 [accepted]
PHST- 2021/11/25 00:00 [revised]
PHST- 2022/01/27 12:18 [entrez]
PHST- 2022/01/28 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
AID - ARM.a2022.0006 [pii]
AID - 10.5603/ARM.a2022.0006 [doi]
PST - aheadofprint
SO  - Adv Respir Med. 2022 Jan 27. doi: 10.5603/ARM.a2022.0006.