PMID- 3508521
OWN - NLM
STAT- MEDLINE
DCOM- 19890609
LR  - 20141120
IS  - 0079-3647 (Print)
IS  - 0079-3647 (Linking)
VI  - 27
IP  - 4
DP  - 1987
TI  - [The role of the cholinergic system in the regulation of blood flow through the 
      reproductive organs of swine during the estrous cycle].
PG  - 69-83
AB  - The flow in uterine artery (ua) and ovarian artery (oa) of isolated reproductive 
      organs of sows (100-130 kg/head) perfounded with animal own blood and 
      Krebs-Henseleit fluid at the constant pressure of 100 mm Hg was measured. 
      Together with measuring the flow, the tension of the smooth muscle of organ was 
      controlled. Applying acetylocholine (ACh), atropine (A), hexamethonium (H) and 
      phentolamine (F) the analysis of the functions of muscarine (M) and nicotine (N) 
      receptors of the cholinergic system in regulation of blood flow through the 
      reproductive organs during the oestrous cycle was carried out. It was found that 
      application of 0.3 microgram ACh into ua, and 0.5 microgram ACh into oa causes 
      slight increase in the blood flow. Application of ACh in doses of 1 microgram 
      into these vessels causes decrease of the flow and increase in tension and 
      motorics of the organ. A eliminates the influence of ACh upon the tension and 
      motorics of the studied organ and potencializes the decreasing influence of ACh 
      applied in the dose of 1 microgram upon the blood flow. A decreases the flow 
      limiting action of 1 microgram ACh upon the flow, and also eliminates the effect 
      of decrease of flow caused by application of 1 microgram ACh after A. H 
      potencializes the influence of small doses of ACh increasing the flow in ua and 
      oa, but does not influence the flow limiting and tension increasing action of 1 
      microgram dose of ACh. Both A and H in doses applied cause increase in blood flow 
      in the vessel areas under study. The results of the research indicate that 
      changes in the blood flow through the areas under investigation induced by 
      application of ACh are the resultant of three factors. 1. The vasodilatative 
      effect resulting from the stimulation of the receptor M. 2. Stimulation of the 
      cholinergic receptor N and connected with it freeing catecholamines responsible 
      for the tension of vessels and contraction of smooth muscles of the organ. 3. 
      Pressing influence upon the vessels of contracting smooth muscles connected with 
      stimulation of M and N receptors. The sensitivity of vessels in the oa area to 
      M-cholinergic stimulation is lower than that in the ua artery and it is higher in 
      the luteal phase than in pre- and post-ovulation phases in both vessel areas. The 
      magnitude of nicotine reaction of endogenous catecholamines freeing does not 
      undergo significant changes during the oestrous cycle.
FAU - Dynarowicz, I
AU  - Dynarowicz I
AD  - Zaklad Farmakologii, Instytut Podstawowych Nauk Weterynaryjnych, Akademia 
      Rolniczo-Techniczna w Olsztynie.
FAU - Dziegielewski, M
AU  - Dziegielewski M
LA  - pol
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Udzial ukladu cholinergicznego w regulacji przeplywu krwi przez narzad rodny 
      swini w przebiegu cyklu rujowego.
PL  - Poland
TA  - Pol Arch Weter
JT  - Polskie archiwum weterynaryjne
JID - 0023271
SB  - IM
MH  - Animals
MH  - Arteries/*innervation
MH  - *Blood Circulation
MH  - Blood Flow Velocity
MH  - Cholinergic Fibers/*physiology
MH  - Estrus/physiology
MH  - Female
MH  - In Vitro Techniques
MH  - Ovary/*blood supply
MH  - Swine/*physiology
MH  - Uterus/*blood supply
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
PST - ppublish
SO  - Pol Arch Weter. 1987;27(4):69-83.