PMID- 35085518
OWN - NLM
STAT- MEDLINE
DCOM- 20220325
LR  - 20220325
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 918
DP  - 2022 Mar 5
TI  - Schisandrin B promotes Foxp3(+) regulatory T cell expansion by activating heme 
      oxygenase-1 in dendritic cells and exhibits immunomodulatory effects in 
      Th2-mediated allergic asthma.
PG  - 174775
LID - S0014-2999(22)00036-X [pii]
LID - 10.1016/j.ejphar.2022.174775 [doi]
AB  - Allergic asthma is induced by T helper 2 (Th2) responses and allergen-specific 
      immunoglobulin E (IgE). In asthma, regulatory T (Treg) cells play a crucial role 
      in controlling immune homeostasis, and induction of Treg cells is a good strategy 
      to treat Th2-mediated allergic asthma. Schisandrin B (Sch B), the main component 
      isolated from Schisandra chinensis, reportedly possesses various pharmacological 
      properties, but its immunomodulatory mechanism in allergic asthma remains 
      unclear. In the present study, we explored whether Sch B exerts an antiallergic 
      effect through modifying the function of dendritic cells (DCs) to regulate T-cell 
      polarization and further investigated the immunomodulatory effects of Sch B in 
      allergic asthma. Herein, an in vitro study revealed that 20 muM of Sch B-treated 
      bone-marrow-derived DCs exhibited a semi-mature phenotype that secreted low 
      amounts of proinflammatory cytokines including interleukin (IL)-12, IL-1beta, IL-6, 
      and tumor necrosis factor (TNF)-alpha, and expressed decreased levels of surface 
      molecules of cluster of differentiation 80 (CD80) and CD86. Compared to fully 
      mature DCs, these Sch B-treated DCs displayed a regulatory ability to promote 
      CD4(+)Foxp3(+) Treg cell generation via upregulation of heme oxygenase (HO)-1 
      expression. Of note, in a murine model of ovalbumin (OVA)-induced asthma, levels 
      of Th2-type cytokines such as IL-4, IL-5, and IL-13, and C-C motif chemokine 11 
      (CCL11) were dampened, whereas numbers of forkhead box P3 (Foxp3)-positive Treg 
      cells were augmented in Sch B-treated mice. Moreover, administration of 5 mg/kg 
      of Sch B alleviated the cardinal features of Th2-mediated allergic asthma, 
      namely, serum OVA-specific IgE production, the development of airway 
      hyperresponsiveness (AHR), and airway inflammation. Collectively, these findings 
      indicate that the effectiveness of Sch B treatment against Th2-mediated allergic 
      asthma was at least partially due to enhancement of DC induction of Treg cells, 
      and Sch B can possibly be developed as an immunomodulatory adjuvant to treat 
      allergic asthma.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Chiang, Chen-Yuan
AU  - Chiang CY
AD  - Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang 
      Hospital, Taipei Medical University, Taipei, Taiwan; Division of Pulmonary 
      Medicine, Department of Internal Medicine, School of Medicine, College of 
      Medicine, Taipei Medical University, Taipei, Taiwan.
FAU - Chang, Jer-Hwa
AU  - Chang JH
AD  - Division of Pulmonary Medicine, Department of Internal Medicine, School of 
      Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; School 
      of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, 
      Taiwan; Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, 
      Taipei, Taiwan.
FAU - Chuang, Hsiao-Chi
AU  - Chuang HC
AD  - School of Respiratory Therapy, College of Medicine, Taipei Medical University, 
      Taipei, Taiwan; Division of Pulmonary Medicine, Department of Internal Medicine, 
      Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Cell 
      Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical 
      University, Taipei, Taiwan.
FAU - Fan, Chia-Kwung
AU  - Fan CK
AD  - Department of Molecular Parasitology and Tropical Diseases, School of Medicine, 
      College of Medicine, Taipei Medical University, Taipei, Taiwan.
FAU - Hou, Tsung-Yun
AU  - Hou TY
AD  - Division of Rheumatology, Immunology and Allergy, Department of Internal 
      Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Division 
      of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School 
      of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 
      Division of Rheumatology, Immunology and Allergy, Department of Internal 
      Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Lin, Chu-Lun
AU  - Lin CL
AD  - Department of Microbiology and Immunology, School of Medicine, College of 
      Medicine, Taipei Medical University, Taipei, Taiwan.
FAU - Lee, Yueh-Lun
AU  - Lee YL
AD  - Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei 
      Medical University, Taipei, Taiwan; Department of Microbiology and Immunology, 
      School of Medicine, College of Medicine, Taipei Medical University, Taipei, 
      Taiwan. Electronic address: yllee@tmu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20220125
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Cyclooctanes)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Immunomodulating Agents)
RN  - 0 (Lignans)
RN  - 0 (Polycyclic Compounds)
RN  - 02XA4X3KZW (schizandrin B)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Antineoplastic Agents, Phytogenic/pharmacology
MH  - *Asthma/drug therapy/etiology/immunology
MH  - Cyclooctanes/pharmacology
MH  - Dendritic Cells/drug effects/metabolism
MH  - Disease Models, Animal
MH  - Forkhead Transcription Factors/*metabolism
MH  - Heme Oxygenase-1/*metabolism
MH  - *Hypersensitivity/complications/immunology
MH  - Immunoglobulin E/immunology
MH  - Immunomodulating Agents/pharmacology
MH  - Lignans/*pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Polycyclic Compounds/*pharmacology
MH  - Respiratory Hypersensitivity/drug therapy/immunology
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Th2 Cells/*immunology
OTO - NOTNLM
OT  - Allergic asthma
OT  - Dendritic cell
OT  - Heme oxygenase-1
OT  - Schisandrin B
OT  - T cell
EDAT- 2022/01/28 06:00
MHDA- 2022/03/26 06:00
CRDT- 2022/01/27 20:12
PHST- 2021/07/30 00:00 [received]
PHST- 2022/01/17 00:00 [revised]
PHST- 2022/01/21 00:00 [accepted]
PHST- 2022/01/28 06:00 [pubmed]
PHST- 2022/03/26 06:00 [medline]
PHST- 2022/01/27 20:12 [entrez]
AID - S0014-2999(22)00036-X [pii]
AID - 10.1016/j.ejphar.2022.174775 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2022 Mar 5;918:174775. doi: 10.1016/j.ejphar.2022.174775. Epub 
      2022 Jan 25.