PMID- 35086214
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220716
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 70
IP  - 2
DP  - 2022 Feb
TI  - Assessment of retinal manifestations of Parkinson's disease using spectral domain 
      optical coherence tomography: A study in Indian eyes.
PG  - 448-452
LID - 10.4103/ijo.IJO_1409_21 [doi]
AB  - PURPOSE: To assess the retinal manifestations of Parkinson's disease using 
      optical coherence tomography. METHODS: A prospective case-control study comparing 
      30 eyes from 15 patients with Parkinson's disease and 22 eyes from 11 healthy 
      age-matched controls. Total macular subfield thickness and the thickness of the 
      ganglion cell layer, nerve fiber layer, and peripapillary retinal nerve fiber 
      layer were measured with spectral-domain optical coherence tomography (SD-OCT). 
      RESULTS: The mean age of PD patients was 68.4 years +/- 10.64 (range: 46-82) and in 
      the control group was 66.36 +/- 5.22 (range: 64-68). The average disease duration 
      in patients with PD was 6.7 +/- 2.8 years (range: 2-10 years). The mean 
      best-corrected visual acuity in PD was 20/26 and 20/20 in controls, with P = 
      0.0059, which was significant. Significant difference was also found in the 
      contrast sensitivity between both groups. Structural differences in the central 
      macular thickness (P = 0.0001), subfield thicknesses in the superior (P = 0.003), 
      inferior (P = 0.001), nasal (P = 0.004), and temporal subfields (P = 0.017) was 
      seen. Severe thinning of the ganglion cell layer was seen in PD patients (P = 
      0.000) as well as of the nerve fiber layer (P = 0.004). Peripapillary retinal 
      nerve fiber thickness measured showed significant thinning in superotemporal (P = 
      0.000), superonasal (P = 0.04), inferonasal (P = 0.000), inferotemporal (P = 
      0.000), nasal (P = 0.000), and temporal quadrants (P = 0.000). CONCLUSION: Visual 
      dysfunction was observed in patients with PD along with structural alterations on 
      OCT, which included macular volumes, ganglion cell layer, and peripapillary 
      retinal nerve fiber layer.
FAU - Verghese, Shishir
AU  - Verghese S
AD  - Department of Retina and Vitreous, Aravind Eye Hospital and Postgraduate 
      Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.
FAU - Berkowitz, Sean T
AU  - Berkowitz ST
AD  - Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, 
      USA.
FAU - Shah, Virna M
AU  - Shah VM
AD  - Department of Neuro Ophthalmology, Aravind Eye Hospital and Postgraduate 
      Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.
FAU - Shah, Parag
AU  - Shah P
AD  - Department of Retina and Vitreous, Aravind Eye Hospital and Postgraduate 
      Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.
FAU - Priya, S
AU  - Priya S
AD  - Department of Neuro Ophthalmology, Aravind Eye Hospital and Postgraduate 
      Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.
FAU - Saravanan, Veerappan R
AU  - Saravanan VR
AD  - Department of Retina and Vitreous, Aravind Eye Hospital and Postgraduate 
      Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.
FAU - Narendran, Venkatapathy
AU  - Narendran V
AD  - Department of Retina and Vitreous, Aravind Eye Hospital and Postgraduate 
      Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.
FAU - Selvan, V A
AU  - Selvan VA
AD  - Department of Neurology, Kovai Medical College and Hospital, Coimbatore, Tamil 
      Nadu, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Humans
MH  - Nerve Fibers
MH  - *Parkinson Disease/complications/diagnosis
MH  - Retinal Ganglion Cells
MH  - *Tomography, Optical Coherence/methods
PMC - PMC9023951
OTO - NOTNLM
OT  - Ganglion cell layer
OT  - Parkinson's disease
OT  - SD-OCT
OT  - retinal nerve fiber layer
COIS- None
EDAT- 2022/01/29 06:00
MHDA- 2022/03/19 06:00
PMCR- 2022/02/01
CRDT- 2022/01/28 01:00
PHST- 2022/01/28 01:00 [entrez]
PHST- 2022/01/29 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2022/02/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2022_70_2_448_336472 [pii]
AID - IJO-70-448 [pii]
AID - 10.4103/ijo.IJO_1409_21 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2022 Feb;70(2):448-452. doi: 10.4103/ijo.IJO_1409_21.