PMID- 35087478
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220318
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 12
DP  - 2021
TI  - Spatiotemporal Dynamics of Cerebral Vascular Permeability in Type 2 
      Diabetes-Related Cerebral Microangiopathy.
PG  - 805637
LID - 10.3389/fendo.2021.805637 [doi]
LID - 805637
AB  - AIMS: Diabetes-related cerebral microangiopathy can manifest as cerebral small 
      vessel disease (CSVD) and exhibit cognitive decline. To find the early change of 
      function in advance, this study examined the spatiotemporal dynamics of cerebral 
      vascular permeability (Ktrans) in the progression of type 2 diabetes mellitus 
      (T2DM). METHODS: Ktrans was cross-sectionally measured in T2DM and non-diabetes 
      groups with or without CSVD using dynamic contrast-enhanced MRI (DCE-MRI). 
      RESULTS: In all patients with T2DM, the Ktrans of white matter (WM) was 
      increased, whereas the Ktrans of gray matter (GM) was increased only in T2DM with 
      CSVD. The involvement of WM was earlier than GM and was before the CSVD features 
      could be visualized on MRI. Among the commonly available four CSVD items of MRI, 
      microbleeds were the most sensitive, indicating the increased permeability in all 
      patients. Increased Ktrans in T2DM was more associated with moderate WM 
      hyperintensity but less with the presence of lacunae or multiple perivascular 
      spaces, in contrast to patients without diabetes. The differential correlation 
      suggested distinct mechanisms underlying diabetes-related CSVD and other CSVDs. 
      CONCLUSIONS: This study highlights the early development of cerebral 
      microangiopathy with increased BBB leakage in T2DM, before the CSVD features can 
      be visualized on MRI. The results may increase the proactivity of clinicians in 
      recognizing the subsequent neurological comorbidities.
CI  - Copyright (c) 2022 Chen, Lu, Shu and Sun.
FAU - Chen, Ying-Chen
AU  - Chen YC
AD  - Department of Medical Imaging, National Cheng Kung University Hospital, College 
      of Medicine, National Cheng Kung University, Tainan, Taiwan.
AD  - Department of Radiology, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan.
FAU - Lu, Bing-Ze
AU  - Lu BZ
AD  - Department of Mathematics, College of Science, National Cheng Kung University, 
      Tainan, Taiwan.
FAU - Shu, Yu-Chen
AU  - Shu YC
AD  - Department of Mathematics, College of Science, National Cheng Kung University, 
      Tainan, Taiwan.
FAU - Sun, Yuan-Ting
AU  - Sun YT
AD  - Department of Neurology, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
AD  - Department of Medical Genomics, National Cheng Kung University Hospital, College 
      of Medicine, National Cheng Kung University, Tainan, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220111
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood-Brain Barrier
MH  - Brain/*blood supply/diagnostic imaging
MH  - *Capillary Permeability
MH  - Cerebral Small Vessel Diseases/*complications/physiopathology
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
PMC - PMC8786705
OTO - NOTNLM
OT  - blood-brain barrier
OT  - cerebral small vessel disease
OT  - diabetes mellitus
OT  - microangiopathy
OT  - permeability
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/01/29 06:00
MHDA- 2022/03/19 06:00
PMCR- 2021/01/01
CRDT- 2022/01/28 05:54
PHST- 2021/10/30 00:00 [received]
PHST- 2021/12/13 00:00 [accepted]
PHST- 2022/01/28 05:54 [entrez]
PHST- 2022/01/29 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2021.805637 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Jan 11;12:805637. doi: 
      10.3389/fendo.2021.805637. eCollection 2021.