PMID- 35089263
OWN - NLM
STAT- MEDLINE
DCOM- 20220201
LR  - 20220201
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 68
IP  - 2
DP  - 2022 Feb 1
TI  - Effects of Continuous-Flow Left Ventricular Assist Device Therapy on Peripheral 
      Vascular Function.
PG  - 214-219
LID - 10.1097/MAT.0000000000001447 [doi]
AB  - The peripheral vascular effects of continuous-flow left ventricular assist device 
      (CF-LVAD) implantation are still unclear. The aim of the current study was to 
      determine peripheral vascular function before and after implantation of CF-LVAD 
      in patients with end-stage heart failure (HF), and to compare this data to age- 
      and sex-matched chronic heart failure with reduced ejection fraction (HFrEF) 
      patients. Forty-three consecutive end-stage HF patients (New York Heart 
      Association [NYHA] class III/IV; three women and 40 men; mean age 53 +/- 11 years) 
      who planned to receive CF-LVAD implantation comprised the LVAD patient 
      population, and their clinical characteristics, preoperative and third 
      postoperative month peripheral vascular function assessment data including 
      flow-mediated dilation (FMD) and pulsatility index (PI) assessed by ultrasound 
      Doppler in brachial artery were compared to age- and sex-matched chronic, stable 
      HFrEF patients (NYHA class II; five women and 30 men; mean age 51 +/- 10 years). 
      After CF-LVAD implantation, median FMD decreased from 5.4 to 3.7% (p < 0.001), 
      and median PI decreased from 6.9 to 1.4 (p < 0.001). In patients with end-stage 
      HF before CF-LVAD implantation, FMD and PI were significantly lower compared to 
      the chronic HFrEF patients (FMD: 5.4% +/- 0.9% vs. 7.6% +/- 1.1%; p < 0.001, 
      respectively) and (PI: 6.9 +/- 1.3 vs. 7.4 +/- 1.2; p = 0.023, respectively). The 
      current study revealed impaired peripheral vascular function in the end-stage HF 
      patients compared to stable HFrEF patients, and documented the deterioration of 
      peripheral vascular function after CF-LVAD implantation. These results suggest 
      that impaired peripheral vascular function in the CF-LVAD patients compared to 
      preoperative assessment is a consequence of the nonpulsatile blood flow due to 
      the continuous-flow mechanical support.
CI  - Copyright (c) ASAIO 2021.
FAU - Kaya, Ersin
AU  - Kaya E
AD  - From the Department of Cardiology, Ege University School of Medicine, Izmir, 
      Turkey.
FAU - Kocabas, Umut
AU  - Kocabas U
AUID- ORCID: 0000-0001-6424-9399
AD  - From the Department of Cardiology, Ege University School of Medicine, Izmir, 
      Turkey.
AD  - Department of Cardiology, Baskent University Istanbul Hospital, Istanbul, Turkey.
FAU - Simsek, Evrim
AU  - Simsek E
AD  - From the Department of Cardiology, Ege University School of Medicine, Izmir, 
      Turkey.
FAU - Nalbantgil, Sanem
AU  - Nalbantgil S
AD  - From the Department of Cardiology, Ege University School of Medicine, Izmir, 
      Turkey.
FAU - Kahraman, Umit
AU  - Kahraman U
AD  - Department of Cardiovascular Surgery, Ege University School of Medicine, Izmir, 
      Turkey.
FAU - Engin, Cagatay
AU  - Engin C
AD  - Department of Cardiovascular Surgery, Ege University School of Medicine, Izmir, 
      Turkey.
FAU - Yagdi, Tahir
AU  - Yagdi T
AD  - Department of Cardiovascular Surgery, Ege University School of Medicine, Izmir, 
      Turkey.
FAU - Ozbaran, Mustafa
AU  - Ozbaran M
AD  - Department of Cardiovascular Surgery, Ege University School of Medicine, Izmir, 
      Turkey.
FAU - Akilli, Azem
AU  - Akilli A
AD  - From the Department of Cardiology, Ege University School of Medicine, Izmir, 
      Turkey.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Adult
MH  - Female
MH  - *Heart Failure/surgery
MH  - *Heart-Assist Devices/adverse effects
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume
MH  - Ventricular Function, Left
COIS- Disclosure: The authors have no conflicts of interest to report.
EDAT- 2022/01/29 06:00
MHDA- 2022/02/02 06:00
CRDT- 2022/01/28 12:12
PHST- 2022/01/28 12:12 [entrez]
PHST- 2022/01/29 06:00 [pubmed]
PHST- 2022/02/02 06:00 [medline]
AID - 00002480-202202000-00012 [pii]
AID - 10.1097/MAT.0000000000001447 [doi]
PST - ppublish
SO  - ASAIO J. 2022 Feb 1;68(2):214-219. doi: 10.1097/MAT.0000000000001447.