PMID- 35089673
OWN - NLM
STAT- MEDLINE
DCOM- 20220307
LR  - 20220531
IS  - 1897-9483 (Electronic)
IS  - 0032-3772 (Linking)
VI  - 132
IP  - 1
DP  - 2022 Jan 28
TI  - The clinician's guide to radiotherapy complications.
LID - 16190 [pii]
LID - 10.20452/pamw.16190 [doi]
AB  - Radiotherapy is one of the oldest cancer treatment modalities, used for over 100 
      years. As its efficacy has been steadily increasing due to the introduction of 
      novel treatment methods, adverse events (AEs) still pose a major obstacle 
      limiting the therapeutic benefits in some patients and negatively impacting 
      treatment outcomes. In light of the technological progress, the focus has been 
      shifted from improving the efficacy to safeguarding patients from the most severe 
      AEs through improvements of safety and accuracy of radiation delivery. Currently, 
      with radiation therapy being an effective treatment associated with frequent 
      therapeutic success and leading to increased and prolonged survival, the problem 
      of treatment‑related AEs is growing as there are numerous survivors whose health 
      and quality of life may be adversely affected. Due to the limited access to 
      radiation oncologists, patients presenting with AEs are often referred to other 
      professionals for advice, and as survivorship prolongs, the AEs may aggravate 
      current patient comorbidities or reveal undiagnosed diseases. Thus, it is 
      important that doctors other than oncologists be familiar with the fundamentals 
      of radiation therapy-related AEs and their management. In this review, we present 
      the most common and severe AEs of radiotherapy associated with damage to the 
      nervous, respiratory, cardiovascular, gastrointestinal, and urogenital systems. 
      We also describe the pathogenesis of these AEs, and provide guidelines for 
      prevention, risk assessment, diagnosis, and treatment. Novel findings and future 
      perspectives in this field are also elucidated, including examples of ongoing 
      clinical trials aimed not only at improving treatment outcomes but also at 
      reducing the risk of radiotherapy complications in cancer treatment survivors.
FAU - Fendler, Wojciech
AU  - Fendler W
AD  - Department of Biostatistics and Translational Medicine, Medical University of 
      Lodz, Lodz, Poland
AD  - Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, 
      Massachusetts, United States
FAU - Tomasik, Bartlomiej
AU  - Tomasik B
AD  - Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University 
      of Gdansk, Gdansk, Poland
FAU - Atkins, Katelyn
AU  - Atkins K
AD  - Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, 
      California, United States
FAU - Stawiski, Konrad
AU  - Stawiski K
AD  - Department of Biostatistics and Translational Medicine, Medical University of 
      Lodz, Lodz, Poland
FAU - Chalubinska-Fendler, Justyna
AU  - Chalubinska-Fendler J
AD  - Department of Radiotherapy, Military Medical Institute, Warsaw, Poland. 
      jchalubinska-fendler@wim.mil.pl
FAU - Kozono, David
AU  - Kozono D
AD  - Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, 
      Massachusetts, United States
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220128
PL  - Poland
TA  - Pol Arch Intern Med
JT  - Polish archives of internal medicine
JID - 101700960
SB  - IM
MH  - Humans
MH  - *Quality of Life
MH  - Radiotherapy/*adverse effects
MH  - Treatment Outcome
EDAT- 2022/01/29 06:00
MHDA- 2022/03/08 06:00
CRDT- 2022/01/28 14:04
PHST- 2022/01/28 14:04 [entrez]
PHST- 2022/01/29 06:00 [pubmed]
PHST- 2022/03/08 06:00 [medline]
AID - 16190 [pii]
AID - 10.20452/pamw.16190 [doi]
PST - ppublish
SO  - Pol Arch Intern Med. 2022 Jan 28;132(1):16190. doi: 10.20452/pamw.16190. Epub 
      2022 Jan 28.