PMID- 35090123
OWN - NLM
STAT- MEDLINE
DCOM- 20220425
LR  - 20220425
IS  - 1520-4812 (Electronic)
IS  - 1043-1802 (Linking)
VI  - 33
IP  - 2
DP  - 2022 Feb 16
TI  - Facile Synthesis of a Redox-Responsive Hyperbranched Polymer Prodrug as a 
      Unimolecular Micelle for the Tumor-Selective Drug Delivery.
PG  - 411-417
LID - 10.1021/acs.bioconjchem.2c00013 [doi]
AB  - Demicellization of the self-assembled multimolecular micelles upon dilution 
      restricts their application as drug delivery systems (DDSs) for tumor treatment. 
      Here, a redox-responsive hyperbranched polymer prodrug (HBPP) was designed with a 
      high drug content of 62.0% as a unimolecular micelle for the tumor-selective drug 
      delivery, via the facile self-condensing vinyl polymerization (SCVP) of 
      redox-responsive doxorubicin-based prodrug monomer MA-SS-DOX and poly(ethylene 
      glycol) methacrylate (PEGMA) with p-chloromethylstyrene (CMS) as an inimer. The 
      unimolecular micelle could be easily obtained with a hydrodynamic diameter of 122 
      nm, showing excellent GSH-triggered drug release performance with a cumulative 
      release of 60.9% within 85 h but a low premature drug leakage of 3.2%. The 
      unimolecular micelle exhibited selective tumor growth inhibition on HepG2 cells 
      but no obvious cytotoxicity on L02 cells.
FAU - Li, Jie
AU  - Li J
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
FAU - Liu, Peng
AU  - Liu P
AUID- ORCID: 0000-0003-1198-4925
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
LA  - eng
PT  - Journal Article
DEP - 20220128
PL  - United States
TA  - Bioconjug Chem
JT  - Bioconjugate chemistry
JID - 9010319
RN  - 0 (Drug Carriers)
RN  - 0 (Micelles)
RN  - 0 (Polymers)
RN  - 0 (Prodrugs)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Doxorubicin/pharmacology/therapeutic use
MH  - Drug Carriers
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - Hydrogen-Ion Concentration
MH  - *Micelles
MH  - Oxidation-Reduction
MH  - Polyethylene Glycols
MH  - Polymers
MH  - *Prodrugs/pharmacology
EDAT- 2022/01/29 06:00
MHDA- 2022/04/26 06:00
CRDT- 2022/01/28 20:03
PHST- 2022/01/29 06:00 [pubmed]
PHST- 2022/04/26 06:00 [medline]
PHST- 2022/01/28 20:03 [entrez]
AID - 10.1021/acs.bioconjchem.2c00013 [doi]
PST - ppublish
SO  - Bioconjug Chem. 2022 Feb 16;33(2):411-417. doi: 10.1021/acs.bioconjchem.2c00013. 
      Epub 2022 Jan 28.