PMID- 35091022
OWN - NLM
STAT- MEDLINE
DCOM- 20220222
LR  - 20220222
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 299
DP  - 2022 Apr 15
TI  - Insights into disruption of lipid metabolism in digestive gland of female scallop 
      Chlamys farreri under B[a]P exposure.
PG  - 118904
LID - S0269-7491(22)00118-X [pii]
LID - 10.1016/j.envpol.2022.118904 [doi]
AB  - Lipids are the main energy support during gametogenesis. Digestive gland is the 
      key organ of aquatic animal metabolism for storing nutrition and supplying 
      energy. It participates in a variety of life activities (such as growth, 
      digestion, immunity, and reproduction). Nutrients stored in digestive glands, 
      especially lipids, provide energy for reproductive behaviors such as 
      gametogenesis and ovulation. A large number of studies have confirmed the 
      accumulation of lipids from digestive gland to gonad during gametogenesis. At 
      present, the research on the interference mechanism of persistent organic 
      pollutants (POPs) on lipid metabolism of aquatic animals and the adaptive 
      response of aquatic animals to POPs stress focus on biochemical levels or a few 
      genes. The potential molecular mechanism of lipid metabolism interference needs 
      to be further studied. In addition, as an important stage of aquatic animals, the 
      reproductive period is a vigorous period of lipid metabolism. However, at 
      present, there is no report on the molecular mechanism of POPs interfering with 
      the lipid metabolism of the digestive gland in the reproductive process of 
      aquatic animals. In this study, female scallop C. farreri was cultured in natural 
      seawater and exposed to 4 mug/L B[a]P in seawater. Transcriptome analysis of 
      digestive glands at multiple stages (proliferative stage, growth stage, mature 
      stage and spawn stage) was performed, and iPath pathway analysis was used to 
      analyze lipid metabolism pathways and differential genes. The interference 
      mechanism of lipid metabolism in bivalves during reproductive period was 
      revealed. This study will provide valuable genomic information on the role of 
      digestive glands in lipid metabolism and reproduction of C. farreri, and will 
      contribute to further functional genomics of bivalves and other closely related 
      species.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Gao, Zhongyuan
AU  - Gao Z
AD  - The Key Laboratory of Mariculture, Ministry of Education, Ocean University of 
      China, Qingdao, 266003, China.
FAU - Pan, Luqing
AU  - Pan L
AD  - The Key Laboratory of Mariculture, Ministry of Education, Ocean University of 
      China, Qingdao, 266003, China. Electronic address: panlq@ouc.edu.cn.
FAU - Xu, Ruiyi
AU  - Xu R
AD  - The Key Laboratory of Mariculture, Ministry of Education, Ocean University of 
      China, Qingdao, 266003, China.
FAU - Zhou, Yueyao
AU  - Zhou Y
AD  - The Key Laboratory of Mariculture, Ministry of Education, Ocean University of 
      China, Qingdao, 266003, China.
FAU - Li, Dongyu
AU  - Li D
AD  - The Key Laboratory of Mariculture, Ministry of Education, Ocean University of 
      China, Qingdao, 266003, China.
LA  - eng
PT  - Journal Article
DEP - 20220125
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 3417WMA06D (Benzo(a)pyrene)
SB  - IM
MH  - Animals
MH  - Benzo(a)pyrene/metabolism
MH  - Female
MH  - Gene Expression Profiling
MH  - *Lipid Metabolism
MH  - *Pectinidae
MH  - Reproduction
OTO - NOTNLM
OT  - Benzo[a]pyrene
OT  - Chlamys farreri
OT  - Lipid metabolism
OT  - Reproduction
OT  - Transcriptome
EDAT- 2022/01/30 06:00
MHDA- 2022/02/23 06:00
CRDT- 2022/01/29 05:35
PHST- 2021/09/14 00:00 [received]
PHST- 2022/01/20 00:00 [revised]
PHST- 2022/01/23 00:00 [accepted]
PHST- 2022/01/30 06:00 [pubmed]
PHST- 2022/02/23 06:00 [medline]
PHST- 2022/01/29 05:35 [entrez]
AID - S0269-7491(22)00118-X [pii]
AID - 10.1016/j.envpol.2022.118904 [doi]
PST - ppublish
SO  - Environ Pollut. 2022 Apr 15;299:118904. doi: 10.1016/j.envpol.2022.118904. Epub 
      2022 Jan 25.