PMID- 35091254
OWN - NLM
STAT- MEDLINE
DCOM- 20220303
LR  - 20240117
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 33
DP  - 2022
TI  - Responses to positive affect and unique resting-state connectivity in individuals 
      at clinical high-risk for psychosis.
PG  - 102946
LID - S2213-1582(22)00011-0 [pii]
LID - 10.1016/j.nicl.2022.102946 [doi]
LID - 102946
AB  - Individuals at clinical high-risk for psychosis (CHR) report dampened positive 
      affect, while this deficit appears to be an important clinical marker, our 
      current understanding of underlying causes is limited. Dysfunctional regulatory 
      strategies (i.e., abnormal use of dampening, self-focused, or emotion-focused 
      strategies) may account for dampening affect but has not yet been examined. 
      Participants (57 CHR and 56 healthy controls) completed the Response to Positive 
      Affect Scale, clinical interviews, and resting-state scan examining nucleus 
      accumbens (NAcc) connectivity. Individuals at CHR for psychosis showed greater 
      dampening (but no differences in self/emotion-focus) in self-reported response to 
      positive affect compared to healthy controls. In individuals at CHR, higher 
      levels of dampening and lower levels of self-focus were associated with higher 
      positive and lower negative symptoms. Dampening responses were related to 
      decreased dorsal and rostral anterior cingulate cortex-NAcc resting-state 
      connectivity in the CHR group but increased dorsal and rostral anterior cingulate 
      cortex-NAcc resting-state connectivity in the healthy control group. Self-focused 
      responses were related to increased dorsolateral prefrontal cortex-NAcc 
      resting-state connectivity in the CHR group but decreased resting-state 
      connectivity in the healthy control group. Self-reported dampening of positive 
      affect was elevated in individuals at CHR for psychosis. Dampening and 
      self-focused responses were associated with distinct resting-state connectivity 
      compared to peers, suggesting unique mechanisms underlying these emotion 
      regulation strategies. Responses to positive affect may be a useful target for 
      cognitive treatment, but individuals at CHR show distinct neurocorrelates and may 
      require a tailored approach.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Damme, Katherine S F
AU  - Damme KSF
AD  - Department of Psychology, Northwestern University, Evanston, IL, USA; Institute 
      for Innovations in Developmental Sciences (DevSci), Northwestern University, 
      Evanston and Chicago, IL, USA. Electronic address: kate.damme@u.northwestern.edu.
FAU - Gupta, Tina
AU  - Gupta T
AD  - Department of Psychology, Northwestern University, Evanston, IL, USA; Institute 
      for Innovations in Developmental Sciences (DevSci), Northwestern University, 
      Evanston and Chicago, IL, USA.
FAU - Haase, Claudia M
AU  - Haase CM
AD  - Department of Psychology, Northwestern University, Evanston, IL, USA; Institute 
      for Innovations in Developmental Sciences (DevSci), Northwestern University, 
      Evanston and Chicago, IL, USA; Human Development and Social Policy, Northwestern 
      University, Evanston, IL, USA; Institute for Policy Research (IPR), Northwestern 
      University, Chicago, IL, USA.
FAU - Mittal, Vijay A
AU  - Mittal VA
AD  - Department of Psychology, Northwestern University, Evanston, IL, USA; Institute 
      for Innovations in Developmental Sciences (DevSci), Northwestern University, 
      Evanston and Chicago, IL, USA; Human Development and Social Policy, Northwestern 
      University, Evanston, IL, USA; Institute for Policy Research (IPR), Northwestern 
      University, Chicago, IL, USA; Department of Psychiatry, Northwestern University, 
      Chicago, IL, USA; Medical Social Sciences, Northwestern University, Chicago, IL, 
      USA.
LA  - eng
GR  - T32 MH126368/MH/NIMH NIH HHS/United States
GR  - R21 AI115231/AI/NIAID NIH HHS/United States
GR  - R01 HD094650/HD/NICHD NIH HHS/United States
GR  - R01 GM118741/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220122
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
SB  - IM
MH  - Emotions
MH  - Gyrus Cinguli
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Neural Pathways/diagnostic imaging
MH  - Nucleus Accumbens
MH  - *Psychotic Disorders
PMC - PMC8800133
OTO - NOTNLM
OT  - Anterior cingulate cortex
OT  - Clinical risk for psychosis
OT  - Emotion regulation
OT  - Nucleus accumbens
OT  - Positive affect
OT  - Resting-state connectivity
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/01/30 06:00
MHDA- 2022/03/04 06:00
PMCR- 2022/01/22
CRDT- 2022/01/29 05:38
PHST- 2021/10/02 00:00 [received]
PHST- 2021/12/10 00:00 [revised]
PHST- 2022/01/19 00:00 [accepted]
PHST- 2022/01/30 06:00 [pubmed]
PHST- 2022/03/04 06:00 [medline]
PHST- 2022/01/29 05:38 [entrez]
PHST- 2022/01/22 00:00 [pmc-release]
AID - S2213-1582(22)00011-0 [pii]
AID - 102946 [pii]
AID - 10.1016/j.nicl.2022.102946 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2022;33:102946. doi: 10.1016/j.nicl.2022.102946. Epub 2022 Jan 
      22.