PMID- 35092749
OWN - NLM
STAT- MEDLINE
DCOM- 20220228
LR  - 20220228
IS  - 1096-0384 (Electronic)
IS  - 0003-9861 (Linking)
VI  - 717
DP  - 2022 Mar 15
TI  - Cardiometabolic associations of circulating Lipocalin-2 in adults with varying 
      degrees of adiposity and insulin resistance.
PG  - 109138
LID - S0003-9861(22)00023-6 [pii]
LID - 10.1016/j.abb.2022.109138 [doi]
AB  - Lipocalin (Lcn2) acts as a mediator of several inflammatory processes. However, 
      evidence on the role of Lcn2 in regulating adiposity and type 2 diabetes mellitus 
      (T2DM) is scarce. Therefore, our study aimed to evaluate the associations between 
      Lcn2 and cardiometabolic parameters among Arab adults with varying degrees of 
      adiposity and insulin resistance. A total of 819 adult Saudi participants (307 
      males and 512 females) with and without T2DM were included. Anthropometrics, 
      metabolic profile and circulating Lcn2 were assessed. Circulating Lcn2 was 
      significantly highest in the obese group independent of age and sex (p = 0.004), 
      but this significance was lost after stratification to T2DM status. Comparison 
      within age groups revealed that among T2DM participants aged 60-70 years, Lcn2 
      levels were significantly lower than their younger counterparts in both non-obese 
      and obese groups (unadjusted p = 0.04 and < 0.001, respectively). Lcn2 was 
      inversely associated with diastolic blood pressure (R = -0.25, p = 0.01) and 
      triglycerides (R = 0.23; p = 0.04) as well as positively associated with 
      adiponectin (R = 0.27; p = 0.005) among non-obese, non-T2DM participants. In the 
      T2DM/obese group (N = 328), Lcn2 was inversely associated with age (R = -0.15; 
      p = 0.008) and positively associated with HDL-cholesterol (R = 0.12; p = 0.04) 
      and adiponectin (R = 0.17; p = 0.002). Our study suggests that circulating Lcn2 
      maybe protective against obesity and T2DM, but prospective studies are needed to 
      confirm findings.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Daoud, Mohammed S
AU  - Daoud MS
AD  - Department of Biochemistry, College of Science, King Saud University, Riyadh, 
      11451, Saudi Arabia. Electronic address: mdawood@ksu.edu.sa.
FAU - Hussain, Syed D
AU  - Hussain SD
AD  - Department of Biochemistry, College of Science, King Saud University, Riyadh, 
      11451, Saudi Arabia. Electronic address: danishhussain121@gmail.com.
FAU - Al-Daghri, Nasser M
AU  - Al-Daghri NM
AD  - Department of Biochemistry, College of Science, King Saud University, Riyadh, 
      11451, Saudi Arabia. Electronic address: ndaghri@ksu.edu.sa.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220126
PL  - United States
TA  - Arch Biochem Biophys
JT  - Archives of biochemistry and biophysics
JID - 0372430
RN  - 0 (Adiponectin)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cytokines)
RN  - 0 (Insulin)
RN  - 0 (Lipocalin-2)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adiponectin/metabolism
MH  - Adiposity
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Cardiovascular Diseases/*metabolism
MH  - Cholesterol, HDL/metabolism
MH  - Cytokines/metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Female
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin Resistance
MH  - Lipocalin-2/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Obesity/metabolism
MH  - Osteoclasts/metabolism
MH  - Triglycerides/metabolism
OTO - NOTNLM
OT  - Cytokines
OT  - Lipocalin-2
OT  - Obesity
OT  - Osteoclast fusion molecules
OT  - Type 2 diabetes
EDAT- 2022/01/30 06:00
MHDA- 2022/03/01 06:00
CRDT- 2022/01/29 20:05
PHST- 2021/08/26 00:00 [received]
PHST- 2022/01/23 00:00 [revised]
PHST- 2022/01/24 00:00 [accepted]
PHST- 2022/01/30 06:00 [pubmed]
PHST- 2022/03/01 06:00 [medline]
PHST- 2022/01/29 20:05 [entrez]
AID - S0003-9861(22)00023-6 [pii]
AID - 10.1016/j.abb.2022.109138 [doi]
PST - ppublish
SO  - Arch Biochem Biophys. 2022 Mar 15;717:109138. doi: 10.1016/j.abb.2022.109138. 
      Epub 2022 Jan 26.