PMID- 35092950
OWN - NLM
STAT- MEDLINE
DCOM- 20220325
LR  - 20220325
IS  - 1361-6528 (Electronic)
IS  - 0957-4484 (Linking)
VI  - 33
IP  - 21
DP  - 2022 Mar 4
TI  - Using scaffolds as drug delivery systems to treat bone tumor.
LID - 10.1088/1361-6528/ac5017 [doi]
AB  - Surgery is the principal strategy to treat osteosarcoma and other types of bone 
      tumors, but it causes bone defects that cannot be healed spontaneously. After 
      surgery, patients still need to receive radiotherapy and/or chemotherapy to 
      prevent tumor recurrence and metastasis, which leads to systemic side effects. 
      Bone scaffolds exhibit the potentials to load cargos (drugs or growth factors) 
      and act as drug delivery systems (DDSs) in the osteosarcoma postoperative 
      treatment. This review introduces current types of bone scaffolds and highlights 
      representative works using scaffolds as DDSs to treat osteosarcomas. Challenges 
      and perspectives in the scaffold-based DDSs are also discussed. This review may 
      provide references to develop effective and safe strategies for osteosarcoma 
      postoperative treatment.
CI  - (c) 2022 IOP Publishing Ltd.
FAU - Wang, Caifeng
AU  - Wang C
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS 
      Center for Excellence in Nanoscience, National Center for Nanoscience and 
      Technology of China, Beijing 100190, People's Republic of China.
AD  - Center of Materials Science and Optoelectronics Engineering, University of 
      Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
FAU - Ma, Zijiu
AU  - Ma Z
AD  - College of Materials Science and Opto-Electronic Technology, University of 
      Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
FAU - Yuan, Kemeng
AU  - Yuan K
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS 
      Center for Excellence in Nanoscience, National Center for Nanoscience and 
      Technology of China, Beijing 100190, People's Republic of China.
AD  - Center of Materials Science and Optoelectronics Engineering, University of 
      Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
FAU - Ji, Tianjiao
AU  - Ji T
AUID- ORCID: 0000-0002-4479-4821
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS 
      Center for Excellence in Nanoscience, National Center for Nanoscience and 
      Technology of China, Beijing 100190, People's Republic of China.
AD  - Center of Materials Science and Optoelectronics Engineering, University of 
      Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220304
PL  - England
TA  - Nanotechnology
JT  - Nanotechnology
JID - 101241272
SB  - IM
MH  - Animals
MH  - Bone Neoplasms/*drug therapy
MH  - Bone Regeneration/drug effects
MH  - Bone and Bones/drug effects
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Tissue Scaffolds/*chemistry
OTO - NOTNLM
OT  - drug delivery systems
OT  - osteosarcoma
OT  - postoperative treatment
OT  - scaffolds
EDAT- 2022/01/30 06:00
MHDA- 2022/03/26 06:00
CRDT- 2022/01/29 20:08
PHST- 2021/09/03 00:00 [received]
PHST- 2022/01/28 00:00 [accepted]
PHST- 2022/01/30 06:00 [pubmed]
PHST- 2022/03/26 06:00 [medline]
PHST- 2022/01/29 20:08 [entrez]
AID - 10.1088/1361-6528/ac5017 [doi]
PST - epublish
SO  - Nanotechnology. 2022 Mar 4;33(21). doi: 10.1088/1361-6528/ac5017.