PMID- 35092984
OWN - NLM
STAT- MEDLINE
DCOM- 20220201
LR  - 20220201
IS  - 0253-9624 (Print)
IS  - 0253-9624 (Linking)
VI  - 56
IP  - 1
DP  - 2022 Jan 6
TI  - [Advances in high-content screening applications in toxicology research].
PG  - 15-19
LID - 10.3760/cma.j.cn112150-20210507-00448 [doi]
AB  - The toxicity data of chemicals and drugs increases rapidly, while the animal 
      experimental-based tests method could not meet the current demand of health risk 
      assessment. The high-throughput screening techniques based on in vitro 
      alternative models, integrating with computational methods and information 
      technology to establish toxicity tests strategy promises to address this problem. 
      High-content screening (HCS) technology uses automated microscopy and 
      quantitative image platforms to perform multi-parameter and high-throughput 
      phenotypic analysis via a visualization and quantification manner, and to quickly 
      and effectively assess toxicity and prioritization of chemicals, which promotes 
      the development of in vitro toxicity tests and computational toxicology. HCS 
      technology has been included as an important tool for Toxicity Testing in the 
      21(st) Century (Tox21) and chemical risk prioritization. Its applications have 
      been widely utilized in the research field of toxicity tests and chemical 
      toxicity mechanisms. In this review, we describe the development of HCS 
      technology, technical points, toxicological applications, and the future 
      directions and challenges of HCS, so as to provide references for the toxicity 
      testing technology and risk assessment methodology.
FAU - Guo, P
AU  - Guo P
AD  - Department of Toxicology, School of Public Health, Sun Yat-sen University, 
      Guangzhou 510080, China.
FAU - Chen, L P
AU  - Chen LP
AD  - Department of Toxicology, School of Public Health, Sun Yat-sen University, 
      Guangzhou 510080, China.
FAU - Chen, W
AU  - Chen W
AD  - Department of Toxicology, School of Public Health, Sun Yat-sen University, 
      Guangzhou 510080, China.
LA  - chi
GR  - 2017YFC1600201/National Key Research and Development Program of China/
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Yu Fang Yi Xue Za Zhi
JT  - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
JID - 7904962
SB  - IM
MH  - Animals
MH  - *High-Throughput Screening Assays
MH  - Research Design
MH  - Risk Assessment
MH  - *Toxicity Tests
EDAT- 2022/01/31 06:00
MHDA- 2022/02/02 06:00
CRDT- 2022/01/30 10:09
PHST- 2022/01/30 10:09 [entrez]
PHST- 2022/01/31 06:00 [pubmed]
PHST- 2022/02/02 06:00 [medline]
AID - 10.3760/cma.j.cn112150-20210507-00448 [doi]
PST - ppublish
SO  - Zhonghua Yu Fang Yi Xue Za Zhi. 2022 Jan 6;56(1):15-19. doi: 
      10.3760/cma.j.cn112150-20210507-00448.