PMID- 35093116
OWN - NLM
STAT- MEDLINE
DCOM- 20220203
LR  - 20240405
IS  - 1546-0096 (Electronic)
IS  - 1546-0096 (Linking)
VI  - 20
IP  - 1
DP  - 2022 Jan 29
TI  - The efficacy and safety of intra-articular injection of triamcinolone acetonide 
      versus triamcinolone hexacetonide for treatment of juvenile idiopathic arthritis.
PG  - 5
LID - 10.1186/s12969-022-00666-x [doi]
LID - 5
AB  - OBJECTIVES: Juvenile idiopathic arthritis (JIA) is the most common childhood 
      rheumatic disease. Intra-articular corticosteroids joint injection (IAJI), with 
      triamcinolone hexacetonide (TH) or triamcinolone acetonide (TA), is an effective 
      additional treatment for oligo and polyarticular JIA. Previous studies have shown 
      the benefits of TH over TA; however, TA is still used in many pediatric 
      rheumatology centers. Our unit has experience with both regimens, and therefore 
      we aimed to compare the efficacy and safety of TA versus TH for JIA patients. 
      METHODS: Chart review of JIA patients who were randomly (based on drug 
      availability) treated with TA or TH IAJI during 2010-2019. Primary outcomes for 
      efficacy were defined as full recovery from arthritis one month after IAJI and a 
      relapse rate of arthritis 3 months after IAJI. Primary outcome for safety was 
      defined as the occurrence of adverse events (AEs) during the follow up period 
      after IAJI. RESULTS: Overall, 292 joints of 102 JIA patients were treated (138 
      TA/154 TH joints). Complete recovery after one month was documented in 107 
      (69.6%) of TA treated joints and 96 (69.5%) of TH treated joints (P = 0.232). 
      However, rate of relapse after 3 months was significantly higher for TA treated 
      joints (27 (20.1%) vs. 13 (8.8%), respectively, P < 0.01). No AEs were documented 
      except minor scars at four joint injection sites. CONCLUSION: The recovery from 
      arthritis was similar (~ 70%) with both regimens, however relapse rate was more 
      than double in TA as compared to TH injected joints. These findings are important 
      due to a contemporary shortage of TH in the US market.
CI  - (c) 2022. The Author(s).
FAU - Rubin, Shiri
AU  - Rubin S
AD  - Pediatric Hematology Oncology Division, Schneider Children's Medical Center of 
      Israel, Petach Tikva, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Ohana, Orly
AU  - Ohana O
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach 
      Tikva, Israel.
FAU - Goldberg, Ori
AU  - Goldberg O
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Pediatric Pulmonary Unit, Schneider Children's Medical Center of Israel, Petach 
      Tikva, Israel.
FAU - Peled, Orit
AU  - Peled O
AD  - Department of Pharmacy, Schneider Children's Medical Center of Israel, Petach 
      Tikva, Israel.
FAU - Gendler, Yulia
AU  - Gendler Y
AD  - The Department of Nursing, Ariel University, Ariel, Israel.
FAU - Habot-Wilner, Zohar
AU  - Habot-Wilner Z
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
FAU - Levinsky, Yoel
AU  - Levinsky Y
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Department of Pediatrics B, Schneider Children's Medical Center of Israel, Petach 
      Tikva, Israel.
FAU - Tal, Rotem
AU  - Tal R
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, 
      Petach Tikva, Israel.
FAU - Harel, Liora
AU  - Harel L
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, 
      Petach Tikva, Israel.
FAU - Amarilyo, Gil
AU  - Amarilyo G
AUID- ORCID: 0000-0002-3888-429X
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 
      gamarilyo@clalit.org.il.
AD  - Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, 
      Petach Tikva, Israel. gamarilyo@clalit.org.il.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20220129
PL  - England
TA  - Pediatr Rheumatol Online J
JT  - Pediatric rheumatology online journal
JID - 101248897
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Glucocorticoids)
RN  - F446C597KA (Triamcinolone Acetonide)
RN  - I7GT1U99Y9 (triamcinolone hexacetonide)
SB  - IM
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Arthritis, Juvenile/*drug therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Infant
MH  - *Injections, Intra-Articular
MH  - Male
MH  - Recurrence
MH  - Triamcinolone Acetonide/*analogs & derivatives/*therapeutic use
PMC - PMC8801083
OTO - NOTNLM
OT  - Intra-articular corticosteroids
OT  - Juvenile idiopathic arthritis
OT  - Triamcinolone
COIS- The authors declare that they have no competing interests.
EDAT- 2022/01/31 06:00
MHDA- 2022/02/04 06:00
PMCR- 2022/01/29
CRDT- 2022/01/30 20:27
PHST- 2021/08/30 00:00 [received]
PHST- 2022/01/16 00:00 [accepted]
PHST- 2022/01/30 20:27 [entrez]
PHST- 2022/01/31 06:00 [pubmed]
PHST- 2022/02/04 06:00 [medline]
PHST- 2022/01/29 00:00 [pmc-release]
AID - 10.1186/s12969-022-00666-x [pii]
AID - 666 [pii]
AID - 10.1186/s12969-022-00666-x [doi]
PST - epublish
SO  - Pediatr Rheumatol Online J. 2022 Jan 29;20(1):5. doi: 10.1186/s12969-022-00666-x.