PMID- 35096858
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220201
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - Oxidative Stress in Intestinal Ischemia-Reperfusion.
PG  - 750731
LID - 10.3389/fmed.2021.750731 [doi]
LID - 750731
AB  - Ischemia-reperfusion (I/R) injury is a manifestation of tissue or organ damage 
      that is followed by ischemia and exacerbated by the return of blood flow to a 
      previously damaged tissue or organ. The intestines are one of the most sensitive 
      tissues and organs to I/R injury. Moreover, the adverse consequences of 
      intestinal I/R (II/R) injury are not limited to the intestine itself and can also 
      lead to damage of the distant tissues and organs. The mechanism of II/R is 
      extremely complex and oxidative stress is the key link in the pathogenesis of 
      II/R injury. This study summarizes the roles of oxidative stress and its 
      signaling pathways involved in II/R. The signaling pathways that mitigate II/R 
      injury include the nuclear factor erythroid-related factor 2 (Nrf2)-mediated 
      signaling pathway, Wnt/beta-catenin pathway, and phosphatidylinositol kinase 3 
      (PI3K)/Akt pathway; those that aggravate II/R injury include the Janus 
      kinase/signal transducer and activator of transcription (JAK/STAT) pathway, 
      Toll-like receptor (TLR) receptor-mediated signaling pathway, protein kinase CbetaII 
      (PKCbetaII)/p66shc pathway, and microRNA (miRNA)/p66shc pathway; the effect of miRNA 
      on related pathways and mitochondrial DNA translocation. The aforementioned 
      pathways provide new ideas for further exploring the occurrence and development 
      of II/R and more effective treatments for II/R injury.
CI  - Copyright (c) 2022 Li, Wang and Fan.
FAU - Li, Guangyao
AU  - Li G
AD  - Department of General Surgery, The Third People's Hospital of Dalian, Dalian 
      Medical University, Dalian, China.
AD  - Department of Central Laboratory, The Third People's Hospital of Dalian, Dalian 
      Medical University, Dalian, China.
FAU - Wang, Shuang
AU  - Wang S
AD  - Department of Endocrinology, The Second Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Fan, Zhe
AU  - Fan Z
AD  - Department of General Surgery, The Third People's Hospital of Dalian, Dalian 
      Medical University, Dalian, China.
AD  - Department of Central Laboratory, The Third People's Hospital of Dalian, Dalian 
      Medical University, Dalian, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220114
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8795364
OTO - NOTNLM
OT  - intestinal
OT  - ischemia-reperfusion
OT  - oxidative stress
OT  - review
OT  - signal pathway
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/01 06:00
MHDA- 2022/02/01 06:01
PMCR- 2022/01/14
CRDT- 2022/01/31 06:00
PHST- 2021/07/31 00:00 [received]
PHST- 2021/12/16 00:00 [accepted]
PHST- 2022/01/31 06:00 [entrez]
PHST- 2022/02/01 06:00 [pubmed]
PHST- 2022/02/01 06:01 [medline]
PHST- 2022/01/14 00:00 [pmc-release]
AID - 10.3389/fmed.2021.750731 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Jan 14;8:750731. doi: 10.3389/fmed.2021.750731. 
      eCollection 2021.